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7045310 |
Redox reversible bipyridyl-osmium complex conjugates
Novel bipyridyl-osmium complex conjugates and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials...
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7045284 |
Method for selective inactivation of viral replication
Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA...
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7045283 |
Methods of high-throughput screening for internalizing antibodies
This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand;...
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7041442 |
Peptides for vaccinating against human CMV
The present invention relates to peptides or peptide derivatives of the 65 kD lower matrix phoshpoprotein of human cytomegalovirus. The peptides disclosed are useful for determining whether...
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7041293 |
HIV env antibodies
The invention provides antibodies specific for HIV env, including monoclonal antibodies and related hybridomas. The antibodies block CD4/g120 binding and reduce reverse transcriptase activity in...
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7041444 |
Murine calicivirus
The invention disclosed herein relates to a newly discovered murine norovirus, and compositions and methods related thereto.
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7041441 |
Phage display of intact domains at high copy number
Disclosed is a phage display system in which the molecules to be displayed (i.e., molecules of interest) are bound to dispensable capsid polypeptides such as SOC (small outer capsid) and HOC...
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7041443 |
Porcine reproductive and respiratory syndrome virus and methods of use
The present invention provides isolated European-like porcine reproductive and respiratory syndrome viruses, polynucleotides, and polypeptides. The present invention also provides methods for...
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7037664 |
Apoptosis marker antibodies and methods of use
Disclosed are antibodies that specifically recognize the new amino terminus of a protein cleaved by a protease during apoptosis. Methods of using and making the antibodies are also provided. The...
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7037508 |
Pestivirus mutants and vaccines containing the same
The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5′ nontranslated region...
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7037644 |
Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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7037645 |
Methods for identification of CDS8+ suppressor molecules
The present invention relates to a bioactive molecule, herein referred to as the CD8 + suppressor molecule, that is produced by the CD8 + subset of human T-lymphocytes and suppresses type-1 human...
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7037707 |
Method for generating influenza viruses and vaccines
The present invention is based on the discovery that a high titer reassortant influenza virus is produced in mammalian cell culture by replacing the NS gene of the A/PuertoRico/3/24 master strain...
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7033748 |
Identification of microbial polynucleotides expressed during infection of a host
The invention provides methods useful for identifying polynucleotides expressed in vivo by a microbe during infection of a host. Antibodies against antigens that are expressed by the microbe in...
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7033769 |
Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
A method for discovering one or more peptides adapted for specific binding to a microorganism of interest. The method comprises (i) identifying an antimicrobial peptide having antimicrobial...
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7033750 |
Recombinant P53 adenovirus methods and compositions
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected...
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7033749 |
Ribonuclease resistant RNA preparation and utilization
The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
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7033751 |
Antigenic fragment of human T-lymphotropic virus
Antigenic fragments of human T-lymphotropic virus (HTLV), their fusion proteins with glutathione S-tranferase (GST) or thioredoxin (Thio), and a process for producing the fusion proteins thereof....
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7029843 |
Method for the quantitative detection of nucleic acids
Provided herein is a method for the quantitative detection of nucleic acids based on the use of a calibrator, suitable primers and probes, and a nucleic acid polymerase with 5′-3′ nuclease...
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7029881 |
Methods for constructing DNA library and support carrying DNA library immobilized thereon
Method and apparatus for constructing a cDNA library by hybridizing mRNA with oligo (dT) on a support and treating with a reverse transcriptase to immobilized complementary DNA, or for constructing...
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7029842 |
Signal sequence trapping
The present invention allows the screening of previously established genebanks or libraries by proxy for genes encoding secreted, partially secreted, or cell surface-displayed polypeptides of...
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7026112 |
Oligonucleotides for the amplification and detection of Epstein Barr Virus (EBV) nucleic acid
The present invention is concerned with oligonucleotides that can be used as in the amplification and detection of Epstein Barr Virus (EBV) nucleic acid, in particular RNA-specific sequences....
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7026140 |
Serum paraoxonase
Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of...
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7026137 |
Hepatitis
A screening method of identifying a compound for treating hepatitis. Also disclosed is a method for evaluating responsiveness of a subject having hepatitis to a drug.
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7026130 |
Binding protein
A 24kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24kd protein, are disclosed. Processes for production...
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7026113 |
EIA vaccine and diagnostic
The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows...
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7026154 |
Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses
The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of...
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7018523 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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7019111 |
Glycosylated ligand/receptor specificity exchangers specific for bacterial adhesion receptors
The present invention generally relates to compositions and methods for preventing and treating human diseases including, but not limited to, pathogens such as bacteria, yeast, parasites, fungus,...
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7018792 |
Influenza sensor
A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also...
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7019129 |
Dark quenchers for donor-acceptor energy transfer
The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially...
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7014814 |
Support for substances for detection, apparatus for processing same, method of processing same, apparatus for making same, and method of making same
The present invention relates to a support for substances for detection, an apparatus for processing same, a method of processing same, an apparatus for making same, and a method of making same....
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7015317 |
Polynucleotides for the detection and quantification of hepatitis B virus nucleic acids
The present invention provides polynucleotides that can specifically hybridise to Hepatitis B virus (HBV) nucleic acids from all genotypes. These polynucleotides can be used in genotype-independent...
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7008774 |
Practical serological assay for the clinical diagnosis of leishmaniasis
Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are...
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7008794 |
Method and apparatus for assay for multiple analytes
A method and apparatus for assay of multiple analytes. The method uses a sensing element comprising a substrate upon which is arranged a multiplicity of recognition elements, such that each element...
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7005257 |
Detection of antibiotic resistance in microorganisms
The invention relates to a process for detecting antibiotic resistances in microorganisms, in particular in bacteria, and to reagent kits which are suitable for implementing the process.
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7005130 |
Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E
The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns...
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7002004 |
Biomolecule and/or cellular arrays on metal surfaces
Disclosed is a process to construct multi-component biomolecule or cellular arrays suitable for use in SPR imaging studies of large molecule, cellular/molecular, and cell/cell interactions. Also...
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7001719 |
Devices and methods for microorganism detection
A device that includes at least two chambers separated by an activatable seal wherein upon activation of the seal the two chambers are in communication, and further wherein at least one chamber of...
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7001718 |
Method of inhibiting pathogenicity of infectious agents
The present invention relates to methods of detecting or identifying inhibitors of a Z-DNA binding ligand to Z-DNA, methods of inhibiting the pathogenicity of an infectious agent, antiviral...
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6991899 |
Cells for detection of influenza and parainfluenza viruses
The invention provides cell lines which are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic mink lung cells...
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6986995 |
Methods of diagnosing liver fibrosis
The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting...
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6986986 |
Polyvalent display libraries
The invention is directed to inter alia two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display...
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6984526 |
Spectrophotometric method for determining the viability of a sample containing platelets
A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined...
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6984486 |
Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof
The invention pertains to synthetic (s) peptides derived from the viral regulatory protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly the chemical synthesis of the 96...
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6979534 |
Compositions and methods for detection of antibody binding to cells
The invention relates to methods of agglutinating or capturing cells comprising providing a mixture comprising a population of cells and a population of bacteriophage expressing a first antibody on...
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6979543 |
Method for detecting biological agents
A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate...
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6979535 |
Human immunodeficiency virus type 2 (HIV-2) env polypeptide and diagnostic assays
A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a...
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6977180 |
Biosensor
The present invention relates, in general, to biosensors and, in particular, to bioelectronic sensors comprising a macromolecule immobilized on an electrode surface so that a redox cofactor that is...
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6977144 |
Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
The present invention relates to nucleic acids encoding SID® polypeptides which bind selectively to a polypeptide encoded by a pathogenic strain of the hepatitis C virus, as well as to the SID®...
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