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7083936 |
Aminodextran compositions and conjugates and method of making and using them
A composition containing polydisperse aminodextran polymer molecules is soluble in an aqueous solution at a concentration of 10 mg/ml. The molecules therein have a narrow size distribution...
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7081352 |
Chemiluminescent influenza diagnostic kit
A chemiluminescent system for detecting the presence of influenza virus in a biological fluid sample is provided. An influenza diagnostic kit is provided which includes (1) a sampling device for...
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7078166 |
Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
The invention describes the display of exogenous polypeptides on filamentous phage using a fusion between the exogenous polypeptide and phage pVII or pIX proteins. In particular, phage particles...
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7078189 |
Preparing membrane receptors from extracellular baciloviruses
Method of producing a recombinant membrane receptor protein by introducing a baculovirus expression vector encoding the membrane receptor protein into a host cell, culturing the resultant host cell...
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7078061 |
Methods, compositions and kits for biomarker extraction
The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods,...
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7077982 |
Molecular electric wire, molecular electric wire circuit using the same and process for producing the molecular electric wire circuit
A molecular electric wire that is formed of an environmentally benign ecological material and enables a microscopic wiring, a molecular electric wire circuit using the molecular electric wire, and...
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7078224 |
Cell concentration and lysate clearance using paramagnetic particles
Methods are disclosed for using paramagnetic particles to concentrate or harvest cells. Methods are also disclosed for clearing a solution of disrupted biological material, such as a lysate of...
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7074613 |
Monoclonal antibody directed against cells of human renal cell carcinoma
The invention concerns a hybridome called 5C5 (CNCM no I-2184) and the monoclonal antibody 5C5 which it produces. Said monoclonal antibody which specifically recognises most human renal cell...
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7074555 |
Detection of West Nile Virus
A method and device for detecting a West Nile Virus (WNV) infection including contacting a biological sample from a subject with an anti-IgM antibody and a recombinant WNV E polypeptide and...
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7074596 |
Synthesis and use of anti-reverse mRNA cap analogues
The ability to synthesize capped RNA transcripts in vitro has been of considerable value in a variety of applications. However, one-third to one-half of the caps have, until now, been incorporated...
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7074553 |
Retrovirus associated with myelodysplastic syndromes and uses thereof
The present invention relates first, to the identification of a novel retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the...
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7074554 |
Antibodies specific for NEBR1 and methods of use thereof
Materials and methods are provided to inhibit HIV replication in targeted host cells.
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7074556 |
cDNA synthesis improvements
The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods,...
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7074560 |
Purification of tissue plasminogen activator (tPA)
A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are...
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7070987 |
Guided mode resonant filter biosensor using a linear grating surface structure
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7070790 |
Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope 1 genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the...
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7070924 |
Method of detecting cell death and detection reagent
A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in...
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7067638 |
Small round structured virus (SRSV) detection kit
This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related which makes it possible to detect most SRSV-related viruses and further to distinguish their serotypes...
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7067251 |
Methods of directly selecting cells expressing inserts of interest
The present invention relates to a high efficiency method of introducing DNA into linear DNA viruses such as poxvirus, a method of producing libraries in linear DNA viruses such as poxvirus, and...
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7067324 |
Photon reducing agents for fluorescence assays
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon...
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7067247 |
Hepatitis B virus surface protein
We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be...
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7067249 |
Inhibition of hepatitis B virus (HBV) replication by RNA interference
The present invention relates to the inhibition of Hepatitis B virus (HBV) replication by RNA molecules of the present invention. Specifically, the RNA molecules of the present invention are...
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7067248 |
Screening method for orthopoxvirus antivirals
The focus of the present invention is an effective anti-poxvirus drug for use in treating or preventing human disease caused by pathogenic poxviruses. More particularly, the present invention...
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7067643 |
Systems for the detection of target sequences
The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and...
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7067252 |
Method for genome mining for secreted protein genes
The present invention relates to a method for screening for compounds secreted by an organism, comprising
(a) raising antibodies against secreted products of a donor organism, (b) providing a gene...
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7067246 |
Method for determining prognosis of HIV infected individuals
The serum levels of anti-tat antibodies, tat protein, and p24 protein are predictive of disease progression in HIV infected individuals and serve as prognostic markers. The present invention...
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7063943 |
Methods for producing members of specific binding pairs
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are...
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7060799 |
Antibody for ligand capture assay
The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase...
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7060804 |
Method for isolating proteins or protein and nucleic acid associations, or particle and protein complexes, reagent and uses
The invention concerns a method for isolating proteins and/or protein and nucleic acid associations in a sample, comprising steps which consist in: contacting said sample and magnetic colloidal...
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7060433 |
Methods and compositions for screening using diphtheria toxin constructs
The invention relates to methods and compositions utilizing diphtheria toxin for screening purposes. The invention is particularly useful in screening for modulators of IgE synthesis, secretion and...
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7056658 |
Multiple epitope fusion protein
Multiple epitope fusion proteins and immunoassays using the same are disclosed. The multiple epitope fusion proteins are encompassed by the general structural formula (A) x −(B) y −C 2 which...
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7056657 |
Apparatus and methods for magnetic separation
Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium. Test medium within a reaction chamber is caused to flow past a collecting surface,...
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7056689 |
Methods of treating and detecting cancer using viruses
The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The...
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7058616 |
Method and system for predicting resistance of a disease to a therapeutic agent using a neural network
A method and system for predicting the resistance of a disease to a therapeutic agent is provided. Further provided is a method and system for designing a therapeutic treatment agent for a patient...
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7056735 |
Mimetics and inhibitors of the interaction between Vpr (HIV viral protein of regulation) and ANT (Mitochondrial adenine nucleotide translocator)
The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane...
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7056656 |
Tat-derived oligourea and its method of production and use in high affinity and specific binding HIV-1 TAR RNA
This invention relates to the use of oligourea molecules to specifically inhibit protein-nucleic acid interactions. In particular, it provides an oligourea molecule that competes with the Tat...
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7056679 |
Target specific screening and its use for identifying target binders
The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a...
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7052692 |
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells...
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7052833 |
Absorptive hypercalciuria locus on human chromosome 1
Disclosed is a region on human chromosome 1 that provides a genetic basis for absorptive hypercalciuria. The genes, proteins, and other biological materials provided are envisioned for use in...
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7052831 |
Detection of multiple analytes from a single sample using a multi-well, multi-analyte flow-through diagnostic test device
The present invention provides a method and device for conducting a rapid in vitro enzyme immunoassay test for the direct and qualitative detection of two or more viral antigens from specimens of...
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7053179 |
Five-Helix protein
Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino...
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7052696 |
Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
Antigenic epitopes of hepatitis C virus (HCV) and mosaic HCV polypeptides useful as reagents in assays for the diagnosis or monitoring of HCV in a biological sample. The antigenic epitopes and...
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7052830 |
Hepatitis C virus peptides and uses thereof
Novel hepatitis C virus (HCV) polypetides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine...
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7052832 |
Methods for the treatment of cellular proliferative disorders
The present invention relates to methods of identifying the susceptibility of cells to reovirus infection by measuring constitutive ras-MAP signaling. The invention also pertains to methods using...
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7052676 |
Methods for inhibition of HIV replication using a small molecule inhibitor
Methods are provided for inhibiting or suppressing viral replication in an infected host cell. More specifically, methods are provided for inhibiting or suppressing viral replication in an infected...
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7048935 |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
The present invention provides, among other things, methods of removing virus from a sample, a composition comprising a solid support matrix to which is attached a cyanovirin, a conjugate...
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7048931 |
Compositions and methods for the therapy and diagnosis of prostate cancer
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
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7049060 |
HCV anti-core monoclonal antibodies
Monoclonal antibodies that specifically bind to HCV core antigen. Also provided are hybridoma cell lines which secrete these antibodies, methods for making and using these antibodies, including...
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7049067 |
Oligonucleotide for detection of HIV-1 and detection method
An oligonucleotide useful for detection of an RNA derived from HIV-1 consisting of at least 10 consecutive bases in any of SEQ ID NOS:1, 2, 4 to 10 and 13 to 17, which can bind to a specific site...
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7049059 |
Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression
The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1...
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