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8043857 |
Recombinant BCG strains with enhanced ability to escape the endosome
Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a...
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7897397 |
Cell fusion promoter and utilization of the same
The present invention provides a regeneration promoter for regenerating tissue with the use of somatic stem cells. The invention also provides a cell fusion promoter comprising ATP or its...
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7829684 |
Methods for producing soluble membrane-spanning proteins
Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of...
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7820806 |
Methods for producing soluble membrane spanning proteins
Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of...
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7803602 |
Method for overexpression of zwitterionic polysaccharides
The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular...
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7691989 |
Methods for producing soluble membrane-spanning proteins
Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of...
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7678558 |
Method for overexpression of zwitterionic polysaccharides
The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected...
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7531522 |
Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the...
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7521242 |
Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids
Methods are disclosed herein for inducing homologous recombination in a host cell comprising a target nucleic acid, using a single-stranded nucleic acid molecule. The single-stranded nucleic acid...
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7229804 |
Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
The gene encoding a 4-hydroxybutyryl-CoA transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved...
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7153433 |
Use of functionalized porous membranes or matrices for purification of nucleic acids and corresponding methods
Application of a functionalized porous membrane to purify nucleic acids, the binding properties of the membrane with respect to nucleic acids being adjustable by controlling the conditions of an...
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7150874 |
Vector for integration of heterologous sequences into poxviral genomes
A new DNA vector is disclosed comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. Also disclosed are...
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7060500 |
Single-stranded oligodeoxynucleotide mutational vectors
The invention concerns the introduction of predetermined genetic changes in target genes of a living cell by introducing an oligodeoxynucleotide encoding the predetermined change. The...
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6287841 |
High alkaline serine protease
New PB92 or Subtilisin 309 mutant serine proteases are provided having specific mutations, resulting in an surprisingly better wash performance or in an improved storage stability with at similar...
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6268174 |
Method of stable integration of DNA into neurons
The invention relates to the stable transfection of neurons with DNA encoding proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Also, co-transfection of a functional gene...
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6060277 |
Human AFC1
The hAFC1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hAFC1 polypeptides and...
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6027909 |
Bacillus strain and sporulation assay method
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6027910 |
Process for immobilizing enzymes to the cell wall of a microbial cell by producing a fusion protein
A method is provided for immobilizing an enzyme, comprising immobilizing the enzyme or a functional part thereof to the cell wall of a microbial cell using recombinant DNA techniques. The enzyme is...
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5891692 |
Method for increasing the viability and transformation ability of bacteria during or after storage at low temperatures
The invention relates to improved E. coli bacteria with enhanced viability at low temperatures, methods for producing improved bacterial strains capable of enhanced viability at low temperatures,...
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5869239 |
Library screening method
Materials and methods for homologous-recombination screening of DNA libraries constructed in a eukaryotic host and methods for homologous-recombination chromosome walking for isolating overlapping...
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5866383 |
In vitro ligation of foreign DNA into large eukaryotic viruses
In a preferred embodiment of the invention, methods are provided for the production of viral vectors from large viral genomes (greater than 50 kbp) that incorporate nucleic acid insertions by...
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5856144 |
Direct cloning of DNA fragments
A vector for the direct cloning of the products of PCR protocol incorporates single nucleotide overhangs at one or both ends of a linearized DNA segment. The single nucleotide overhangs are uracil...
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5854039 |
Transformation of pichia methanolica
Methods for transforming Pichia methanolica, and DNA molecules useful in transformation of P. methanolica, are disclosed. P. methanolica cells are exposed, in the presence of DNA molecules, to a...
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5827515 |
Bacillus thuringiensis sporulation gene
The present invention relates to a novel sporulation gene isolated from B. thuringiensis, and a DNA segment comprising the nucleic acid sequences encoding the gene and DNA sequences encoding...
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5756316 |
Molecular cloning by multimerization of plasmids
Novel methods of nucleic acid multimerization using PCR are provided, allowing direct transformation of cells and microorganisms.
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5254466 |
Site-specific modification of the candida tropicals genome
The POX genes of C. tropicalis are disrupted resulting in the complete blockage of the beta-oxidation pathway in the strain. Fermentation of C. tropicalis cells having disrupted genes on alkane,...
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4963487 |
Method for deletion of a gene from a bacteria
Disclosed is a method and linear DNA fragments for use in the deletion of a gene from a bacteria with a single step procedure that is applicable to any essential or nonessential gene which has been...
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4885249 |
Aspergillus niger transformation system
Transformants of Aspergillus niger and related Aspergilli, containing foreign DNA conferring modified properties of expression thereon, are prepared by use of a DNA vector which contains a...
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4833080 |
Regulation of eucaryotic gene expression
Regulation of eucaryotic gene expression is controlled by procaryotic peptides. The peptides recognize specific DNA sequences present in the gene, which may be derived from procaryotic genes, and...
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4735901 |
Transformation of Candida albicans
Candida albicans has been transformed by the insertion of a plasmid comprising a fragment of DNA from Candida albicans containing the intact ADE 2 gene.
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4546082 |
E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
A method for producing secretable and processable biologically useful polypeptides in yeast is provided utilizing vectors including at least a segment of the gene coding for S. cerevisiae...
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4348477 |
Method for preparing a recombinant DNA phage
A method for preparing a novel recombinant DNA, which comprises (1) cleaving with an endonuclease a phage DNA having an endonuclease-sensitive region not in the DNA segment participating in...
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4348478 |
Method for preparation of a recombinant DNA phage
A method for the preparation of a novel recombinant DNA, which comprises (1) cleaving with an endonuclease a temperate phage DNA having an endonuclease-sensitive region not in the DNA segment...
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4082613 |
Process for the production of insulin by genetically transformed fungal cells
A process for the production of insulin using fungal cells. Human insulin producing cells are extracted to obtain the functional genome (the genetic material which determines the capacity of the...
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