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8044195 |
Cross-linked glycopeptide-cephalosporin antibiotics
This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides p...
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7955813 |
Method of using lipid acyltransferase
A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without...
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7884318 |
Systems, methods, and computer-readable medium for determining composition of chemical constituents in a complex mixture
Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition...
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7728127 |
Cross-linked glycopeptide-cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7713931 |
Cross-linked glycopeptide-cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7553635 |
Process for production of cephalosporin C
The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum, to vectors which comprise such a nucleic acid molecule, to Acremonium...
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7288386 |
Method of determining soybean sudden death syndrome resistance in a soybean plant
A method of determining the presence of soybean sudden death syndrome resistance in the soybean plant in a greenhouse setting, the method comprising the steps of: (a) inoculating soil with a low...
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7211377 |
Method for detecting the presence of dormant cryptobiotic microorganisms
Method for the detection of dormant cryptobiotic microbes by detection of electromagnetic radiation emitted from intrinsic alkali earth metal pyridine dicarboxylic acid salts in the 710 nm to 860...
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6913901 |
Procedure for controlling the enumeration of the absolute count of cells or other particles present in a sample
Procedure for controlling the enumeration of the absolute count of cells (or other particles) present in a sample. The procedure consists of the following: to prepare, in known quantities and...
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6750006 |
Method for detecting the presence of microbes and determining their physiological status
Method and apparatus for the detection of microbes in liquids, in air and on non-living surfaces in which samples are exposed to electromagnetic radiation of specific energies capable of exciting...
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6642020 |
Process for preparing cephalosporin derivatives
An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula I: to form a...
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6630338 |
Removing deacetylase contaminant from cephalosporin C acylase using cationic surfactant
An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A deacetylase contaminant is...
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6503727 |
Process for the preparation of an antibiotic
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a...
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6383773 |
Penicillin conversion
The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular,...
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6368820 |
Process for the preparation of cephalosporins using acremonium chrysogenum
An improved process for production of an N-acylated cephalosporin is described. The process utilizes an Acremonium strain which has been modified to express an acyl transferase of a filamentous...
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6319684 |
Process for the fermentative production of cephalosporin
The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the...
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6180360 |
Process of producing β-lactam antibiotics applying micro-organisms with increased ligase activity
The present invention relates to the biosynthesis of β-lactam antibiotics. More specifically, the invention relates to processes of producing β-lactam antibiotics in vivo and in vitro. Also c...
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6165758 |
Purifying cephalosporin C acylase and regenerating a carrier immobilizing cephalosporin C acylase
An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A carrier containing an...
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6071713 |
Bioprocesses for preparing 7-ACA and 7-ADAC
A bioprocess for preparing adipoyl-7-ACA comprising the steps: (a) transforming cells of a strain of Penicillium chrysogenum which produces isopenicillin N with an expression vector containing DNA...
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5942411 |
Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity
The present invention relates to the biosynthesis of β-lactam antibiotics. More specifically, the invention relates to processes of producing β-lactam antibiotics in vivo and in vitro. Also c...
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5919680 |
Process for the production of SSC's via expandase activity on penicillin G
An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum...
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5804429 |
Cephalosporin C acylase
A mutant CC acylase wherein at least one amino acid at the Ala49, Met164, Ser166, Met174, Glu358, Met465, Met506, or Met750 position of the amino acid sequence of the native CC acylase is replaced...
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5780260 |
Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier
An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an...
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5753458 |
Acylation method for penicillins and cephalosporins
A method for providing a semisynthetic β-lactam antibiotic by enzyme catalyzed acylation of the parent β-lactam with an activated derivative of the side chain acid wherein a modulator, which c...
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5726032 |
Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA
An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 2-(carboxyethylthio)acetyl- and 3-(carboxymethylthio)propionyl-7-ADCA, using a...
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5629171 |
Recombinant bioprocess for the preparation of 7-amino cephalosporanic acid (7-ACA)
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a...
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5599702 |
D-amino acid oxidase from Trigonopsis variabilis immobilized on porous copolymer beads
D-amino acid oxidase (DAO) in purified, partially purified or crude form is immobilized on a porous bead-shaped support that is a copolymer of vinyl acetate and/or vinyl alcohol and a crosslinking...
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5597704 |
Bioconversion of cephalosporin C to glutaryl-7-aminocephalosporanic acid
A method of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid. The method including obtaining a cell preparation from a microorganism which produces D-amino acid oxidase, the...
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5559005 |
Bioprocess for preparing 7-ACA and 7-ADAC
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a...
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5512454 |
Enzymatic acylation of 3-hydroxymethyl cephalosporins
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides...
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5474912 |
Method for increasing production of microbial metabolites by genetic engineering
Targeted gene insertion methodology can increase the production of an antimicrobial metabolite and comprises the steps of: a) identifying the gene in unaltered chromosomal DNA which encodes an...
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5466598 |
Deacetylcephalosporin C acetyltransferase from Acremonium chrysogenum
A DNA is disclosed, which comprises a gene coding for deacetylcephalosporin C acetyltransferase, i.e., an enzyme capable of catalyzing the final step of the biosynthesis of cephalosporin C. The...
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5453374 |
Trigonopsis transformant producing D-amino acid oxidase
A Trigonopsis variabilis transformed with a recombinant DNA containing a D-amino acid oxidase gene capable of expressing in Trigonopsis variabilis is provided. A process for transforming...
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5350680 |
Cephalosporinase testing agent
A cephalosporinase testing agent comprising a cephalosporin antibiotic, a penicillinase inhibitor in an amount of 20% by weight or less based on the weight of the cephalosporin-antibiotic, and a pH...
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5338667 |
Microbiological process for the production of malonyl-7-amino-cephalosporanic acid derivatives using Sphingomonas sp. DSM 7007
Disclosed is a microbiological process which utilizes a biologically pure culture of Sphingomonas sp. DSM 7007 in order to produce a malonyl-7-aminocephalosporanic acid derivative product....
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5296358 |
Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412
The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1...
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5284754 |
Process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives
A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivativesA process for the continuous conversion of cephalosporin derivatives into...
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5268271 |
Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase
Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a ...
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5264346 |
Colorimetric method for beta-lactamase assay and its applications
A novel colorimetric method for beta-lactamase assay and its applications are disclosed. The novel assay method for beta-lactamase is based on the discovery described in this invention. The...
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5082772 |
Process for preparing deacetylcephalosporin C
Deacetoxycephalosporin C synthase obtained from cell-free extracts of Streptomyces clavuligerus was purified to near homogeneity and characterized in inactive form. The amino acid sequence was...
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5079146 |
Method of protection of the carboxy groups in the chemistry of β-lactam compounds
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by ...
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4898817 |
Microorganism immobilization
An improved repetitive, batch-type fermentation process is provided. It includes a first, non-repetitive step of forming a support bearing a film of live and reproductive microorganisms immobilized...
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4753881 |
Purified enzyme and process therefor
Deacetoxycephalosporin C synthetase is provided in purified form via chromatography of crude cell-free extracts over a weak anion exchange resin followed by gel filtration and hydroxylapatite...
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4693977 |
Enzyme immobilization for producing cephalosporin antibiotics
Enzymes extracted from a prokaryotic β-lactam producing microorganism are immobilized on a support for producing desacetoxycephalosporin and analogs thereof from ...
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4536476 |
Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins
Cyclase, epimerase and a ring expansion enzyme are isolated separately from a cell free extract of a prokaryotic beta-lactam producing organism to provide three separate and stable enzyme reagents...
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4533632 |
Production of a cephalosporin by fermentation
A process for greatly improving the yields of cephalosporin nucleus produced by fermentation is described. Cephalosporin C-producing microorganisms are fermented in the presence of an...
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4520101 |
Production of cephalosporin C
Production of undesired desacetylcephalosporin C during fermentation of cephalosporin C-producing microorganisms is substantially reduced by addition of certain phosphorous compounds to the culture...
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4510246 |
Isolation of cyclase, epimerase and a ring expansion enzyme for producing unnatural cephalosporins
The enzymes, cyclase, epimerase and a ring expansion enzyme, are isolated separately from a cell-free extract of a prokaryotic beta-lactam producing organism. The isolated enzymes are used to...
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4506014 |
Plasmid pAC 1, a process for obtaining it and its use
Plasmid pAC 1, which is obtained from Acremonium chrysogenum ATCC 14553 and has a contour length of about 6.7 μm and a molecular size of about 20.9 kilobases (=kb), a process for obtaining it and ...
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4371612 |
Immobilization of biological material with an acrylonitrile polymer
Biological material such as enzymes is immobilized by adsorption or covalent bonding to a micro-porous water-insoluble acrylonitrile polymer containing from 20 μM to 1000 μM of amino groups per g...
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