Matches 1 - 50 out of 299 1 2 3 4 5 6 >


Match Document Document Title
8945885 Minicircle DNA vector preparations and methods of making and using the same  
The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest,...
8927231 Separatome-based protein expression and purification platform  
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic...
8895310 L-rhamnose-inducible expression systems  
The present invention relates to methods for expressing nucleic acid sequences in prokaryotic host cells, where at least one DNA construct which is capable of episomal replication in a host cell...
8884100 Aromatic prenyltransferase from Cannabis  
Nucleic acid molecules from Cannabis sativa (cannabis, hemp, marijuana) have been isolated and characterized, and encode polypeptides having aromatic prenyltransferase activity. Specifically, the...
8871491 Capsular gram-positive bacteria bioconjugate vaccines  
The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier,...
8852911 Method of producing dicer  
The present disclosure provides a method for producing a Dicer polypeptide in a prokaryotic host cell. The present disclosure further provides a purified Dicer complex. The present disclosure...
8796235 Methods for attenuating dengue virus infection  
The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression...
8778683 Vaccines comprising heat-sensitive transgenes  
The present disclosure provides temperature sensitive essential nucleic acid molecules from a psychrophilic bacterium, proteins encoded by the nucleic acid molecules, as well as recombinant cells...
8753864 Recombinant N-glycosylated proteins from procaryotic cells  
The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as...
8669073 Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof  
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of...
8618355 Aromatic prenyltransferase from hop  
Nucleic acid molecules from hop (Humulus lupulus) have been isolated and characterized wherein said nucleic acid molecules encode polypeptides having aromatic prenyltransferase activity Expression...
8592199 Genetic encryption  
The present invention relates to a method to engineer either the genome of a genetically modified organism, other bioengineered reagent, or in vitro translation system for protein synthesis from...
8497096 Methods and materials for increasing expression of recombinant polypeptides  
The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of...
8476041 Glucose transport mutants for production of biomaterial  
A method is disclosed for restoring a Glu+ phenotype to a PTS−/Glu− bacterial cell which was originally capable of utilizing a phosphotransferase transport system (PTS) for carbohydrate transport....
8242244 Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells  
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal...
8217145 Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine  
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host...
8211648 Secretion of antibodies without signal peptides from bacteria  
The present invention is directed generally to compositions and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from prokaryotes without the need for a signal...
8187842 Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals  
The invention provides microbial strains possessing improved properties for production of aspartate-derived amino acids and chemicals. Methods of making such strains are provided. These methods...
8088621 Adenoviral fiber exchange shuttle system  
The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors.
8071339 Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine  
The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the...
8067239 Reagents for recombinogenic engineering and use thereof  
The present invention features homologous recombination methods and systems. The methods and systems promote highly efficient homologous recombination in cells (e.g., in prokaryotic cells). The...
8029789 Method for the mass production of immunoglobulin constant region  
Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and...
8030028 Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof  
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of...
8008041 Site-specific incorporation of redox active amino acids into proteins  
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases,...
8003362 Methods and constructs for high yield expression of clostripain  
The invention provides methods and nucleic acid constructs to express clostripain. The source of the coding region for recombinantly expressed clostripain is Clostridium histolyticum.
7955825 Process for producing CMP-N-acetylneuraminic acid  
The present invention is directed to a process for producing CMP-N-acetylneuraminic acid (CMP-NeuAc), comprising adding to the cultured E. coli cells which has been transformed with both the DNA...
7935511 Aerobic succinate production in bacteria  
Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of...
7919282 Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the cpxR gene  
The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which...
7915025 In vivo incorporation of unnatural amino acids  
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
7846694 Process for producing template DNA and process for producing protein in cell-free protein synthesis system with the use of the same  
Provided is a method of producing a template DNA used for protein synthesis comprising a step of amplifying a linear double-stranded DNA by polymerase chain reaction (PCR), by using a reaction...
7820443 Fast method of transforming competent cells  
The invention relates to a fast method of transforming competent cells, comprising: a. mixing a plasmid DNA with the competent cells suspending within ionic solution to form a mixture;b. plating...
7811801 Site-specific incorporation of redox active amino acids into proteins  
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases,...
7794726 Mutants of lysine decarboxylase, vaccines for periodontitis, and methods of use  
The present invention is directed to mutants of lysine decarboxylase, nucleic acids encoding the mutants, and vaccines comprising the mutants for inhibiting and reducing the development of...
7790847 Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine  
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host...
7790426 Sesquiterpene synthases and methods of use  
The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described...
7781190 Method for constructing and modifying large DNA molecules  
This invention provides a method for combining overlapping DNA molecules comprising: (a) providing first and second DNA fragments, the first having a region homologous to a region in the second;...
7771968 Gene upregulated in cancers of the prostate  
The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8...
7767419 Calibrator for NT-proBNP immunoassay  
The invention provides a method to efficiently express high levels of a recombinant untagged NT-proBNP for use as a calibrator in NT-proBNP immunoassays.
7745184 Process for the biological production of 1,3-propanediol with high yield  
The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the...
7709260 Sealing closure of bacterial ghosts by means of bioaffinity interactions  
The invention relates to a method for preparing closed bacterial ghosts by way of specific interactions between partners of a bioaffinity binding pair, and to the bacterial ghosts which can be...
7709604 Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells  
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal...
7700328 Method for producing an L-tyrosine over-producing bacterial strain  
An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal...
7695931 Carotenoid hydroxylase gene, method for preparing hydroxylated carotenoid, and novel geranylgeranyl pyrophosphate synthase  
The present invention provides a Brevundimonas sp. strain SD212-derived peptide having β-ionone ring-2-hydroxylase activity and a gene encoding the same, to thereby make it possible to produce...
7674621 Plasmids and phages for homologous recombination and methods of use  
Lambda phages that can be used to introduce recombineering functions into host cells are disclosed. Also disclosed are plasmids that can be used to confer recombineering functions to a variety of...
7638297 Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof  
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of...
7611883 Plasmid maintenance  
The invention relates to a system for stable maintenance of a plasmid, to host cells for use in this system and to methods of using the system to obtain a plasmid useful in medical applications....
RE40930 Porcine adenovirus type 3 genome  
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
7504244 Process for constructing strain having compactin hydroxylation ability  
The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are...
7495091 Polynucleotides encoding novel proteins in enteroaggregative Escherichia coli (EAEC) useful for diagnosis and therapy of EAEC infections  
Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of...
7494796 Site-specific incorporation of redox active amino acids into proteins  
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases,...

Matches 1 - 50 out of 299 1 2 3 4 5 6 >