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8163557 |
Chimaeric human papillomavirus 16 L1 virus-like particles and a method for preparing the particles
A method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide comprising the steps of introducing a DNA...
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8158384 |
Methods for reducing or eliminating α-mannosidase resistant glycans in the production of glycoproteins
The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on g...
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8148155 |
Methods for increasing homologous recombination of a nucleic acid sequence
The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous...
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8097445 |
Exo-endo cellulase fusion protein
The present invention relates to a heterologous exo-endo cellulase fusion construct, which encodes a fusion protein having cellulolytic activity comprising a catalytic domain derived from a fungal...
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8067157 |
Expression cloning in filamentous fungi
Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are...
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7923235 |
CIP1 polypeptides and their uses
Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding...
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7759102 |
Talaromyces xylanases
Novel polypeptides possessing (endo)xylanase activity are disclosed which can degrade cellulose implant extracts and plant materials. The polypeptides can cleave β-D-xylan polymers at internal ...
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7723079 |
Trichoderma reesei glucoamylase and homologs thereof
The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments...
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7713719 |
Methods for reducing or eliminating α-mannosidase resistant glycans for the production of glycoproteins
The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on g...
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7666648 |
Isolated polypeptide having arabinofuranosidase activity
Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding...
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7595182 |
Endoglucanase STCE and cellulase preparation containing the same
A novel endoglucanase derived from Staphylotrichum coccosporum, a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The...
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7504244 |
Process for constructing strain having compactin hydroxylation ability
The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are...
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7425450 |
Regulatable growth of filamentous fungi
The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention...
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7378256 |
Aspergillus niger promoter for expressing genes in host cells
The present invention relates to isolated promoter sequences, particularly a promoter isolated from Aspergillus niger designated herein as A4-L or A4 and DNA constructs and vectors including the same.
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7361487 |
Enzyme fusion proteins and their use
Cellulase fusion proteins comprising an endoglucanase core region and a heterologous cellulose binding domain are described. The fusion proteins may be produced by recombinant techniques using...
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7354752 |
Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions
The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous expression...
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7348172 |
Method and DNA constructs for increasing the production level of carbohydrate degrading enzymes in filamentous fungi
The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a...
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7335501 |
Phytases and methods for producing these phytases
The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel...
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7332341 |
Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells
The present invention relates to mutants cells comprising a marker-free modification of a gene, and methods for obtaining and using such mutant cells.
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7332319 |
Heterologous alpha amylase expression in Aspergillus
The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.
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7247441 |
Nucleic acid sequence and protein in addition to polypeptides coding for mannitol dehydrogenases or parts thereof and the production and use thereof in diagnosis and therapy
The invention relates to polypeptides made of mannitol-dehydrogenase of Cladosporium herbarum and Alternaria alternata nucleic acids coding therefor and the use thereof in diagnosis and therapy.
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7220542 |
Expression cloning in filamentous fungi
Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are...
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7189538 |
Hyphal growth in fungi
The present invention provides a method for producing desired proteins or chemicals in fungal host cells, which comprise modulating the nucleic acid encoding proteins associated with hyphal growth....
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7163804 |
Non-toxic non-toxigenic non-pathogenic fusarium expression system
The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence...
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7052913 |
Matrices for drug delivery and methods for making and using the same
In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain...
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7022526 |
Reducing branching and enhancing fragmentation in culturing filamentous microorganisms
The invention relates to the field of microorganisms and to the culturing of microorganisms. Means and methods are described for enhancing the culturing properties of filamentous microorganisms,...
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7005561 |
Arabitol or ribitol as positive selectable markers
Disclosed herein are novel methods and materials for selecting transgenic cells. Specifically exemplified herein are positive selection methods that involve conferring to cells the ability to...
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6927026 |
Orotidine-5′-phosphate decarboxylase-gene, gene construct containing said gene and the utilization thereof
The invention relates to an orotidine-5′-phosphate decarboxylase gene having the sequence of SEQ ID NO: 1 or its homologs, to a gene construct comprising this gene or its homologs, and to its u...
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6872526 |
High throughput screening for novel Bioactivities
Disclosed is a process for identifying clones having a specified activity of interest, which process comprises (i) generating one or more expression libraries derived from nucleic acid directly...
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6703200 |
Methods and materials for the rapid and high volume production of a gene knock-out library in an organism
The present invention relates to a method for facilitating site directed homologous recombination in an organism to produce mutants comprising: 1) providing a large insert vector library comprising...
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6582951 |
Method for non-homologous transformation of Yarrowia lipolytica
The invention concerns the integration of a gene of interest into the genome of a Yarrowia strain devoid of zeta sequences, by transforming said strain using a vector bearing zeta sequences.
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6558921 |
Promoters of the genes glutamate deshydrogenase, β-N-acetylhexosaminidase and &ggr -actin and their use in filamentous fungi expression, secretion and antisense systems
An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is...
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6500644 |
Method for in vivo production of a mutant library in cells
A method for in vivo production of a library in cells comprising a multitude of mutated genetic elements, wherein an error-prone polymerase is used in each ancestral cell to replicate all or a part...
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6436643 |
Process for site-directed integration of multiple copies of a gene in a mould
A process for site-directed integration of multiple copies of a gene in a mould is provided, which comprises transforming a mould cell containing in its chromosomal DNA a restriction site for a...
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6379924 |
Protein expression strains
The use of a means to vary Ubc4p or Ubc5p activity in a fungal cell to control the copy number of a plasmid in the cell. The level of Ubc4p or Ubc5p activity may be reduced/abolished (for example...
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6316695 |
Isopentenyl diphosphate isomerase from Hevea brasiliensis and rubber producing method using the same
The present invention cloned a cDNA clone encoding isopentenyl diphosphate (hereafter "IPP") isomerase (EC 5.3.3.2) from a cDNA library of Hevea brasiliensis latex. The clone has a continuous open...
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6300095 |
Promoters of the genes glutamate dehydrogenase β-N-acetylhexosaminidase and γ-actin and their use in filamentous fungi expression, secretion and antisense systems
The invention relates to promoters of the genes glutamate dehydrogenase, β-acetylhexosaminidase and γ-actin and their use in systems of expression, secretion and anti-sense of filamentary fungi. T...
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6291209 |
Alkaline protease deficient filamentaous fungi
The present invention relates to a filamentous fungus useful for the production of heterologous polypeptides, having been modified by recombinant DNA technology in a manner by which the expression...
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6258555 |
DNA encoding ACV synthetase
DNA encoding the gene for the synthetase enzyme capable of generating δ (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and ...
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6255115 |
Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus
The invention relates to Agrobacterium mediated transformation of moulds comprising species of the fungal sub-divisions Ascomycotina, Basidiomycotina, Deuteromycotina, Mastigomycotina, and...
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6111081 |
Lactoferrin variants and uses thereof
The present invention is directed to recombinant nucleic acids encoding lactoferrin variants and portions thereof, having modified iron-binding capacity, and to vectors comprising same recombinant...
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6027910 |
Process for immobilizing enzymes to the cell wall of a microbial cell by producing a fusion protein
A method is provided for immobilizing an enzyme, comprising immobilizing the enzyme or a functional part thereof to the cell wall of a microbial cell using recombinant DNA techniques. The enzyme is...
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6025185 |
Fungus wherein the areA gene has been modified and an areA gene from Aspergillus oryzae
A modified Aspergillus oryzae cell having an area gene which does not express a functional AreA activator, DNA sequences encoding the area gene, and method for using the cell of the invention for...
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6022725 |
Cloning and amplification of the β-glucosidase gene of Trichoderma reesei
A process for expressing extracellular β-glucosidase in a filamentous fungus by expressing a fungal DNA sequence encoding enhanced, deleted or altered β-glucosidase in a recombinant host m...
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6017762 |
Cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica
The present invention relates to a new cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica, to a strain of this species transformed with this cassette, to a...
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6013472 |
GA4 DNA, protein and methods of use
The invention relates to the DNA and protein encoded by the GA4 locus. This protein is believed to be a member of the family of enzymes involved in the biosynthesis of the gibberellin family (GA)...
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5968774 |
Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production
The present invention relates to novel host cells and to methods of producing proteins. More specifically the invention relates to a host cell useful for the expression of heterologous proteins,...
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5965384 |
Methods for producing Humicola lipases in aspergillus
A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA sequences encoding...
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5945339 |
Methods to promote homologous recombination in eukaryotic cells and organisms
The invention concerns genes encoding recombinases that can be used to promote homologous recombination in eukaryotic cells. The application teaches methods by which a recombinase of one species...
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5925515 |
Direct selection of transformants on acetate-containing media
A transformant selection system has been developed, particularly for a β-lactam producing strain, more particularly for P. chrysogenum, by the complementation of a mutation of said β-lactam p...
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