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7611883 |
Plasmid maintenance
The invention relates to a system for stable maintenance of a plasmid, to host cells for use in this system and to methods of using the system to obtain a plasmid useful in medical applications. In...
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7176029 |
Cloning and/or sequencing vector
A cloning and/or sequencing vector enables recombinant clones to be selected directly. The vector encodes a fusion protein which includes a protein poison.
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7125720 |
Plasmid maintenance system for antigen delivery
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid...
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6977176 |
Plasmid maintenance system for antigen delivery
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid...
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6855513 |
Quorum sensing signaling in bacteria
The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention...
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6617163 |
Polynucleotides for mutagenesis in fungus comprising a functional gene in magnaporthe and an impala transposon
The invention concerns a new tool for efficient mutagenesis enabling the generation of a collection of mutants in fungi by random insertion of a characterized Fusarium oxysporum Impala transposon...
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6602712 |
Enterotoxin-deficient bacillus
A enterotoxin-deficient mutant of a member strain of the Bacillus cereus group does not produce HBL enterotoxin, which has been regarded as a human pathogen found in member strains. An...
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6593141 |
Scorpion toxins
This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel modifiers. The invention also relates to the construction of a chimeric gene encoding all or...
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6548246 |
Method and probes for the identification of microbial genes specifically induced during host infection
The present invention relates to a class of microbial coding sequences the transcription or cotranscription of which is specifically induced during microbial infection of a host. These particular...
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6521458 |
Compositions and methods for improved plant transformation
The present invention provides methods for eliminating plants containing non-T-DNA sequences derived from a T-DNA vector. More specifically, the present invention provides a method for killing...
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6503500 |
Biocontrol agent containing an endotoxin gene
The invention provides a biocontrol agent against larvae of mosquitoes and blackflies comprising transgenic Anabaena PCC 7120 carrying a synergistic combination of the endotoxin genes CryIVA and...
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6267966 |
Vaccine production of the Bacillus anthracis protective antigen
Methods of preparing recombinant Bacillus anthracis protective antigen or a variant or fragment thereof for use in vaccines is disclosed. The protein is expressed in a recombinant microorganism...
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6252138 |
Pathogen-induced plant promoters
New pathogen-induced promoters are provided, particularly nematode-induced promoters, which are characterized by their selective induction of expression in the vicinity of the pathogen infection...
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6239329 |
Shoot meristem specific promoter sequences
A novel tissue-specific promoter is provided which has been isolated from the upstream non-coding region of a plant UFO gene. This promoter, operably associated with a nucleic acid sequence...
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6207167 |
Chicken leucocytozoon vaccine
A vaccine strain OU5758 is provided which includes an attenuated immunogenic plasmidless Salmonella enterica serovar-Typhimurium strain OU5046 harboring a recombinant plasmid pOU1500 for immunizing...
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5955332 |
Nucleic acid sequences and plasmids comprising at least one phage resistance mechanism, bacteria containing them and their use
The invention relates to polynucleotides of 1345 bp and 3704 bp and the like, which comprise at least one phage resistance mechanism and obtainable from the total DNA contained in the Lactococcus...
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5928891 |
DNA fragment encoding insecticidal crystal proteins from Bacillus thuringiensis
The invention relates to a vector for transforming microorganisms capable of undergoing sporulation and which contains itself a heterologous insert comprising a DNA sequence coding for at least...
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5922603 |
Method for obtaining strains of trichoderma species
Strains of Trichoderma spp. that are improved in their capacity as biological control agents for phytopathogenic fungi and nematodes are obtained that are able to over-produce a proteinase, with...
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5922583 |
Methods for production of recombinant plasmids
The invention relates to a culture system for stable and high-level production of DNA contained on recombinant plasmids, and to the bacteria and plasmids which comprise the culture system. The...
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5891688 |
DNA encoding lemA-independent GacA and its use in activating gene expression
The present invention exploits the discovery that certain single base changes in the gacA gene coding sequence, which result in certain single amino acid changes in the encoded GacA protein, render...
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5882653 |
Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof
Avirulent Vibrio cholerae strains of O1 (CVD111) and non-O1 (CVD112 and CVD112RM) serogroups having the DNA of the cholera toxin core and the RS1 sequences of the cholera toxin locus deleted, and...
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5840312 |
Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein
A recombinant strain of B. anthracis is characterized in that it can induce the production of protective antibodies against virulent strains of B. anthracis in a human or animal host, and...
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5840554 |
β-Endotoxin expression in pseudomonas fluorescens
Bacillus thuringiensis endotoxin expression in Pseudomonads can be improved by modifying the gene encoding the Bacillus thuringiensis endotoxin. Chimeric genes are created by replacing the segment...
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5766904 |
Phage-resistant streptococcus
DNA fragment of phages which are virulent towards a Streptococcus, capable of conferring on a Streptococcus containing it resistance to at least one phage, especially a fragment homologous or...
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5763247 |
Nucleotide fragments and uses thereof for obtaining bactericide-producing compositions
Nucleotide fragments which encode a bacteriocin composition derived from Micrococcus varians and for preparing compositions to obtain the bacteriocin and for obtaining recombinant microorganisms....
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5686283 |
Genomic DNA encoding the pseudomonas fluorescens alternative sigma factor, RpoS, capable of activating gene expression
Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to...
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5686282 |
DNA encoding the pseudomonas fluorescens sensor/kinase element, lemA, and its use in activating gene expression
Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to...
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5591616 |
Method for transforming monocotyledons
A method for transforming a monocotyledon by which the time required from transformation to regeneration of a plant is shorter so that the frequency of emergence of mutants is smaller than the...
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5545541 |
Stabilization of unstably inherited replicons
The stable maintenance of a replicon in a population of growing cells is ensured by providing the replicon with a sequence which encodes a product capable of killing the cell harboring the replicon...
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5538868 |
Recombinant ricin toxin fragments
Recombinant vectors and methods for constructing ricin B are disclosed. The coding sequence for ricin B was cloned, disposed in suitable expression vectors and produced free of components normally...
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5434065 |
In vivo selection of microbial virulence genes
A genetic system termed in vivo expression technology was devised that positively selects for microbial genes that are specifically induced when microbes infect their host. The method of this...
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5352594 |
Selection and method of making enzymes for perhydrolysis system and for altering substrate specificity, specific activity and catalytic efficiency
The invention relates to methods of making and selecting esterase enzymes having an improved perhydrolysis to hydrolysis ratio, and varying K cat , K m , and K cat /K m and substrate specificity....
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5246844 |
Virulence associated proteins in Borrelia burgdorferi (BB)
The invention relates to a DNA segment encoding a Borrelia burgdorferi antigenic polypeptide. The invention also relates to a purified 30 kDa polypeptide isolated from a virulent strain of B....
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5246839 |
Secretion plasmid comprising the kilgene
The present invention provides for a plasmid, pEAP7ΔP, containing a DNA region capable of inducing extracellular secretion of a useful, physiologically active substance in transformed host and a...
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5231011 |
Segregated folding determinants for small disulfide-rich peptides
The preparation of small peptides with multiple disulfide bonds is accomplished by forming a prepropeptide with an N-terminal excised region separated from the cysteine-rich peptide by one or more...
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5175097 |
Expression and diagnostic use of GAG-1 encoded peptides which are immunologically reactive with antibodies to HIV
Immunologically reactive gag proteins of LAV/HTLV-III are expressed in bacterial cells. The gag proteins are encoded by a recombinant plasmid containing procaryotic transcriptional and...
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5175098 |
Expression and diagnostic use of gag encoded peptides which are immunologically reactive with antibodies to HIV
Immunologically reactive gag proteins of LAV are expresesed in bacterial cells. The gag proteins are encoded by a recombinant plasmid containing procaryotic transcriptional and translational...
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5166056 |
Recombinant trichosanthin and coding sequence
Disclosed are the entire coding sequence for unprocessed and mature trichosanthin from Trichosanthes kirilowii, and primers derived from this coding sequence for use in obtaining the coding...
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5164304 |
Method and vectors for stabilizing hirudin and human laminin B.sub.1 expression
A method for obtaining heterologous peptides from fusion proteins wherein at least one of the fusion components is connective tissue-activating peptide-III is provided. Hirudin, a laminin B 1 ...
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5149638 |
Tylosin biosynthetic genes tylA, tylB and tylI
Provided are gene sequences encoding tylosin biosynthetic gene products. In particular, recombinant DNA vectors comprising DNA sequences encoding the tylA, tylB, tylI and tylG activities of...
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5137721 |
Employing strains of E. coli expressing non-indigenous adhesins and toxoids of E. coli
A vaccine is described for prevention of gastro-enteric disease caused in a mammalian species by a pathogenic microorganism. The vaccine comprises a non-pathogenic microorganism strain containing...
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5106735 |
Cloning of a DNA sequence encoding a Sarcophaga peregrina antibacterial polypeptide precursor
A cloned single-strand DNA comprising nucleotide sequence which encodes an antibacterial polypeptide precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary...
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5059530 |
Expression vector for human TNF
The present invention provides a vector plasmid capable of efficient tumor necrosis factor (TNF) production, a process capable of efficient TNF production in a host transformed with said plasmid...
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5055400 |
Leukotoxin gene of pasteurella haemolytica
The gene coding for Pasteurella haemolytica leukotoxin can be cloned in a plasmic expressed in Escherichia coli. The leukotoxin gene can be isolated from a clone bank of P. haemolytica. The clone...
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5043271 |
DNA encoding rabbit TNE, vector having said DNA inserted thereinto, host transformed with said vector, rabbit TNF polypeptide, and process for production thereof
A novel cloned DNA encoding a rabbit Tumor Necrosis Factor (TNF) or a principal portion thereof, a vector having said DNA inserted thereinto, a host transformed with said vector, a novel...
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5028530 |
AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques
A polynucleotide molecule expressible in a given host comprising the sequence of the araB promoter operably linked to a gene which is heterologous to said host. The heterologous gene codes for a...
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5024837 |
Coleopteran active microorganisms, related insecticide compositions and methods for their production and use
This invention relates to Bacillus thuringiensis strains that have insecticidal activity against lepidopteran and coleopteran insects, the coleopteran-active endotoxin being produced by an acquired...
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4931390 |
Expression of the cloned lysostaphin gene
The present invention provides recombinant plasmids which is transformant microbial hosts express lysostaphin, a bacteriocin that kills most known staphylococcal species. The invention also...
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4910136 |
Cloning and expression of Bacillus thuringiensis toxin gene toxic to beetles of the order Coleoptera
The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a...
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4879226 |
Novel human physiologically active polypeptide
A human physiologically active polypeptide, human Tumor Necrosis Factor (human TNF), comprising a specific amino acid sequence of 155 amino acid residues. The base sequence of the DNA coding for...
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