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6506402 |
Chlortetracycline-containing animal feed compositions and methods for their use
The present invention provides improved chlortetracycline-containing animal feed compositions and processes and apparatuses for their preparation. In certain embodiments, raw fermentation broth...
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6503727 |
Process for the preparation of an antibiotic
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a...
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6383773 |
Penicillin conversion
The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular,...
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6180360 |
Process of producing β-lactam antibiotics applying micro-organisms with increased ligase activity
The present invention relates to the biosynthesis of β-lactam antibiotics. More specifically, the invention relates to processes of producing β-lactam antibiotics in vivo and in vitro. Also c...
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5942411 |
Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity
The present invention relates to the biosynthesis of β-lactam antibiotics. More specifically, the invention relates to processes of producing β-lactam antibiotics in vivo and in vitro. Also c...
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5512454 |
Enzymatic acylation of 3-hydroxymethyl cephalosporins
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides...
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5474912 |
Method for increasing production of microbial metabolites by genetic engineering
Targeted gene insertion methodology can increase the production of an antimicrobial metabolite and comprises the steps of: a) identifying the gene in unaltered chromosomal DNA which encodes an...
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5079146 |
Method of protection of the carboxy groups in the chemistry of β-lactam compounds
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by ...
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4775622 |
Expression, processing and secretion of heterologous protein by yeast
Yeast organisms are caused to express, process, and secrete protein that is normally heterologous to yeast and not required for its viability by transforming yeast with an expression vector...
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4410626 |
Process for the production of 7α-methoxycephalosporin derivatives
7α-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7α-methoxycephalosporin derivatives.
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4368263 |
Production of cephalosporins
An improved strain of Acremonium chrysogenum may be produced by submitting parent strains of Acremonium chrysogenum to protoplast fusion and nuclear fusion and selecting said improved strain from...
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4332891 |
Process for the production of antibiotic Cephamycin C
A process for producing an antibiotic Cephamycin C which comprises cultivating a strain of Streptomyces sp. OFR 1022 in a culture medium to accumulate therein Cephamycin C and recovering said...
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4256835 |
Process for preparing cephamycin C
A novel process for preparing cephamycin C known antibiotic being useful as a medicament and veterinary drug, characterized by cultivating Streptomyces todorominensis sp. nov. in a suitable medium...
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4242449 |
7-Methoxy cephalosporins and process of producing them
The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R1 represents ##STR2## group or...
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4076588 |
Antibiotic SF-1623 substance and the production thereof
A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known...
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4036696 |
Preparation of antibiotics by fermentation
A fermentation process for preparing 7-methoxy substituted cephalosporins. The products are useful as antibiotics and exhibit activity against gram-negative and gram-positive bacteria.
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4017485 |
7-Methoxycephalosporin derivatives
A novel antibiotic C-2801-X represented by the formula ##STR1## is produced by cultivating a microorganism of the genus Streptomyces. The compound is useful in the treatment of mammals, including...
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3985742 |
Process for preparing 3-hydroxymethyl cephalosporins
Disclosed are 7β-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-car
boxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or ...
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3977942 |
Fermentation of cephamycin C
Increased yields of the known and useful antibiotic cephamycin C [7-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-
methoxy-3-ceph em-4-carboxylic acid] are obtained by the addition of D-...
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3976546 |
Cephalosporins
3-Acyloxymethylceph-3-em-4-carboxylic acids, for example cephalosporin C, are enzymically deacylated to their 3-hydroxymethyl analogues by means of esterases produced by culturing microorganisms or...
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3975235 |
Process for the production of cephamycin type antibiotic substances
Novel 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-
cephem-4-carbo xylic acid derivatives. Such derivatives are prepared by subjecting cephamycin type compounds to the action of...
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3974035 |
Process for preparing a cephamycin type antibiotic substance
This invention relates to a process for preparing a cephamycin type antibiotic substance which comprises cultivating a microorganism belonging to the genus Streptomyces under aerobic conditions and...
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3922202 |
Fermentation process
Increased yields of a mixture of the known and useful antibiotics cephamycin A and B are obtained by the addition of L-lysine or L- or DL-α-aminoadipic acid to fermentation media composed of ...
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3886044 |
Process of making cephamycin C by fermentation
Increased yields of the known and useful antibiotic cephamycin C [7-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-
methoxy-3-ceph em-4-carboxylic acid] are obtained by the addition of...
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3865693 |
Process for the production of antibiotic substance cephemimycin
Process for the production of a known antibiotic substance, cephemimycin, by cultivation of a newly discovered microorganism Streptomyces jumonjinensis strain No. 3008 according to any method...
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3769169 |
FERMENTATION PROCESS
A method for improving the yield of 7-(D-5-amino-5-carboxylvaleramido)-3-(carbamoyloxymethyl)-7-
methoxy-3-ceph em-4-carboxylic acid by adding to fermentation media an additive selected from...
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3719563 |
PROCESS FOR PRODUCING 7-(5-AMINO-5-CARBOXYVALERAMIDO)-7-METHOXYCEPHALOSPORAMIC ACID
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