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7384640 |
Mutant cholera holotoxin as an adjuvant
A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an...
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7252942 |
Parallel chromosomal stacking of traits in bacteria
The invention describes a method for the stacking of traits in a recombination proficient host using a phage transduction system. The method makes use of a nucleic acid integration cassette that...
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7135287 |
Human antibodies
The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening...
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7119167 |
Fragment of L. lactis plasmid conferring antiphage activity and uses thereof
The present invention relates to a 2227-bp DNA fragment that confers antiphage activity. Two proteins encoded by this DNA sequence are responsible for the phage resistance phenotype. When...
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7118915 |
Muteins of apolipoprotein D
A method for generating a mutein of human apolipoprotein D having detectable affinity to a given non-natural ligand of apolipoprotein D is disclosed, which comprises the steps of: (a) subjecting...
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7112435 |
Uncoupling of DNA insert propagation and expression of protein for phage display
The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from...
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7049135 |
Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
The present invention relates to methods for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex by screening for polyphage particles. Furthermore,...
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7041441 |
Phage display of intact domains at high copy number
Disclosed is a phage display system in which the molecules to be displayed (i.e., molecules of interest) are bound to dispensable capsid polypeptides such as SOC (small outer capsid) and HOC...
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7033607 |
pH-titratable polyampholytes for delivering polyions to a cell
A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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7022336 |
Methods for attaching proteins to lipidic microparticles with high efficiency
The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a...
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6982087 |
Vectors derived from South African Arbovirus No. 86
Provided herein are alphavirus vectors derived from South African Arbovirus No. 86 (S.A.AR86) comprising attenuating mutations and methods of making the same. Also provided are improved viral...
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6962810 |
Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac
More efficient transfer of genes into host cells or embryos to transform the cells or embryos is facilitated by transposition vectors using the minimal amount of nucleotide sequences in the...
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6943012 |
Helper dependent adenoviral vector system and methods for using the same
A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human...
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6919091 |
Compositions and methods for drug delivery using pH sensitive molecules
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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6893845 |
Surface expression libraries of heteromeric receptors
The invention is directed to a composition of matter consisiting of a plurality of procaryotic cells. The plurality of procaryotic cells contain diverse combinations of first and second DNA...
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6884623 |
Modified plant viruses as vectors of heterologous peptides
The invention relates to assembled particles of a plant virus containing a foreign peptide insert in the coat protein of the virus. The site of the insert is preferably free from direct sequence...
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6881576 |
Formation of polyampholytes in the presence of a polyion
A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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6800288 |
Recombinant influenza A viruses
The invention relates to a recombinant NS gene of an influenza A virus comprising a functional RNA binding domain and a gene sequence modification after nucleotide position 400 of the NS1 gene...
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6787360 |
Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof
The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which...
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6780618 |
Method for improving genetic stability of foreign insert nucleotide sequence in recombinant poliovirus
The present invention relates to (a) methods for improving a genetic stability of an insert nucleotide sequence in a recombinant single-stranded RNA virus vector, which comprises performing a...
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6696295 |
Transducing phages
The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one...
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6696278 |
Method for transfer of DNA segments
The present invention provides a method of transfer of a gene of interest from a first vector to a product vector comprising contacting a first and second vector in vitro with a site-specific...
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6653111 |
Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
The present invention provides a method for deriving an E. coli strain which produces L-theronine from E.coli strain VNIIgenetika 472T23 by transducing with bacteriophage P1 which bears a...
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6645763 |
Immortalized bone marrow mesenchymal stem cell
The present invention provides a safe immortalized bone marrow mesenchymal stem cell obtained by transferring a cell proliferation factor gene inserted between a pair of site-specific recombination...
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6608187 |
C1 bacteriophage lytic system
The invention relates to the identification of C 1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention...
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6537813 |
Concurrent flow mixing methods and apparatuses for the preparation of gene therapy vectors and compositions prepared thereby
The invention relates generally to methods and apparatuses that are adapted for the preparation of gene therapeutic compositions, as well as the compositions formed thereby. The invention also...
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6500611 |
Inviable virus particles as scaffolds for constructing flexible detection systems
An innovative detection system for detecting small numbers of target analytes is disclosed. This system provides a novel method for attaching multiple copies of reporter groups to a single site on...
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6410258 |
Molecular hydrogen production by direct electron transfer
The present invention discloses a method for making hydrogen with biological components including photosystem I complex from a photosynthetic organism and a hydrogenase enzyme in the absence of an...
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6338846 |
Recombinant baculovirus, construction method thereof and insect pesticidal composition containing the same
A recombinant baculovirus, which produces a recombinant polyhedra made up of a baculovirus polyhedrin (PH), a Bacillus thuringiensis crystal protein (CP) and jellyfish Aequorea victoria green...
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6335185 |
Bacteriophage vectors generated by bacteriophage/plasmid recombination
The present invention relates to methods for the generation of lambda (λ) or P1 bacteriophage vectors useful in targeted mutagenesis of eukaryotic cells and the expression of genes and proteins,...
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6319716 |
Bovine adenovirus type 3 genome and vector systems derived therefrom
The present invention provides the complete nucleotide sequence of a bovine adenovirus. The invention further provides bovine adenovirus vectors and expression systems which can be used, among...
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6312939 |
Genetically engineered glutaminase and its use in antiviral and anticancer therapy
DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating...
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6297031 |
Escherichia coli strain and method for producing L-threonine
E. coli strains derived form E. coli strain VNIIgenetika 472t23 and obtained by a process involving transduction by bacteriophage P1 which bears a transposon which inactivates threonine...
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6274147 |
Method for generating nonpathogenic infectious pancreatic necrosis virus (IPNV) from synthetic RNA transcripts
A system for the generation of live, nonpathogenic infectious pancreatic necrosis virus (IPNV), a segmented double-stranded (ds)RNA virus of the Birnavirdae family, using synthetic transcripts...
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6271034 |
One step allelic exchange in mycobacteria using in vitro generated conditional transducing phages
The present invention provides a method for high frequency of allelic exchange in the slow-growing mycobacteria using in vitro generated specialized transducing mycobacteriophages, as well as the...
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6248578 |
Infectious clone for human parainfluenza virus type 3
A system for generating recombinant, human parainfluenza virus, particularly infectious, recombinant, human parainfluenza virus type 3 (HPIV-3) is provided. In one embodiment, the system comprises...
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6245504 |
Transducing phages of Actinomycetales
The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one...
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6159738 |
Method for construction of bacterial strains with increased succinic acid production
A fermentation process for producing succinic acid is provided comprising selecting a bacterial strain that does not produce succinic acid in high yield, disrupting the normal regulation of sugar...
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6159728 |
RNA bacteriophage-based delivery system
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6017732 |
Bacteriophage library displaying immunoglobulin repertoires with a chemical moiety covalently bound within the binding site: production and selection thereof
Repertoires of first specific binding pair (sbp) members wherein each first sbp member has a chemical moiety bound covalently at an amino acid residue within the binding site are made and may be...
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5965415 |
Process for the in vivo recombination of DNA sequences having mismatched bases
The present invention relates to a process of recombination in vivo of partially homologous DNA sequences having up to 30% of base mismatches. According to its essential characteristic, said...
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5932426 |
Molecular presenting system
The invention refers to a molecular presentation system in which viral proteins are foreseen as carriers for heterologous amino acid sequences. Hereby, the viral protein is derived from small...
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5891692 |
Method for increasing the viability and transformation ability of bacteria during or after storage at low temperatures
The invention relates to improved E. coli bacteria with enhanced viability at low temperatures, methods for producing improved bacterial strains capable of enhanced viability at low temperatures,...
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5889190 |
Recombinant plant viral nucleic acids
The present invention is directed to recombinant plant viral nucleic acids and to hosts infected thereby. The recombinant plant viral nucleic acids comprise a native plant viral subgenomic...
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5888764 |
Human fas gene promoter region
Disclosed is a 5' flanking sequence of the human fas gene containing a promoter region. This sequence also contains at least three transcription initiation sites, as well as consensus sequences for...
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5885808 |
Adenovirus with modified binding moiety specific for the target cells
An adenovirus or adenovirus-like particle which has a modified binding specificity conferred by a binding moiety. The binding moiety is heterologous to the adenovirus and is incorporated as a...
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5869339 |
HIV targeted hairpin ribozymes
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule...
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5866385 |
Lactic acid bacterial suppressor mutants and their use as selective markers and as means of containment in lactic acid bacteria
Methods of isolating nonsense suppressor-encoding lactic acid bacteria, cultures and compositions of lactic acid bacteria and plasmids comprising a gene coding for a nonsense suppressor, and a...
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5830690 |
Process for producing polypeptides
The invention relates to the construction and use of novel expression systems that make use of DNA sequences encoding a promoter or promoters along with cis-regulatory elements, such as those for...
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5780279 |
Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
A method for identifying and selecting novel substrates for enzymes is provided. The method comprises constructing a gene fusion comprising DNA encoding a polypeptide fused to DNA encoding a...
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