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7029875 |
PRO1343 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7026300 |
One step immunization procedure for inducing a Chlamydia specific immune response
A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by...
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7026119 |
Methods for generating hypermutable microbes
Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair...
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7026125 |
Heterodimers of retinoid X receptors (RXRS) and other steroid hormone receptors
This invention provides a purified heterodimer comprising an RXR and a hormone receptor. The invention also provides a method of screening ligands for their effect on the activity of an...
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7022498 |
Pro 1325 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7018829 |
Metabolically engineered microbial cell with an altered metabolite production
A recombinant microbial cell comprises at least one increased expressible enzyme activity controlling anabolic metabolism of ammonia as a nutrient source, the increased enzyme activity being an...
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7019124 |
PRO788 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7018811 |
Nucleic acids encoding PRO189 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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RE39015 |
DNA encoding interleukin-B30
Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
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7013219 |
Regulation of endogenous gene expression in cells using zinc finger proteins
The present invention provides methods for modulating expression of endogenous cellular genes using engineered zinc finger proteins.
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7008767 |
Microorganism genomics, compositions and methods related thereto
The present invention provides methods and composition for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides...
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7009045 |
Transformation systems for flavinogenic yeast
This invention is directed to the transformation of the flavinogenic yeasts, Pichia guilliermondii and Candida famata , and mutants thereof, by electroporation (electrotransformation) and by...
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7005561 |
Arabitol or ribitol as positive selectable markers
Disclosed herein are novel methods and materials for selecting transgenic cells. Specifically exemplified herein are positive selection methods that involve conferring to cells the ability to...
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7005129 |
Non-toxic mutants of pathogenic gram-negative bacteria
A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen...
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7001728 |
Protein having PDZ domain sequence
While analyzing changes in gene expression by TNFα in umbilical vascular endothelial cells, a gene showing enhanced expression due to stimulation with TNFα was isolated. After screening with this...
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7001772 |
Product and process for transformation of Thraustochytriales microorganisms
Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide...
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7001732 |
RIP3 associated cell cycle protein
The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host...
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7001595 |
Chemokine β-7 variants
The present invention relates to deletion and substitution mutant polypeptides of human chemokine β-7 (Ckβ-7), as well as nucleic acid molecules encoding such polypeptides and processes for...
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6998476 |
Nucleic acids encoding antagonists of interleukin-15
Disclosure herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
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6995254 |
Polynucleotide encoding the enoyl-acyl carrier protein reductase of Staphylococcus aureus, FAB I
Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing...
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6995255 |
Cellular delivery agent
One aspect of the present invention relates to a nucleic acid construct which includes a first nucleic acid and a second nucleic acid operatively coupled to the first nucleic acid. The first...
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6994994 |
Splice variants of CD40-receptor
The present invention concerns six novel variants of alternative splicing of the CD40 receptor.
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6987026 |
Vector for the transformation of Phaffia rhodozyma and process of transformation thereby
The present invention is directed to a recombinant vector for transforming yeast and a process for transforming yeast thereby, more particularly to a recombinant vector comprising a gene encoding a...
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6987005 |
DNA encoding SNORF33 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors,...
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6984501 |
Voltage-gated potassium channel and its use for development of therapeutics
The invention relates to a novel tension-dependent potassium channel protein Kv6.2 (SEQ ID NO:1). The Kv6.2 gene is expressed preferably in the myocardium or in the hippocampus. Novel functional...
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6982087 |
Vectors derived from South African Arbovirus No. 86
Provided herein are alphavirus vectors derived from South African Arbovirus No. 86 (S.A.AR86) comprising attenuating mutations and methods of making the same. Also provided are improved viral...
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6979556 |
Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic...
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6979443 |
Chemokine α-6
The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6...
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6977176 |
Plasmid maintenance system for antigen delivery
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid...
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6977165 |
Sequence specific recombinase-based methods for producing intron containing vectors and compositions for use in practicing the same
Methods are provided for producing a vector that includes at least one splicable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each...
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6974893 |
Isoform of castor oleate hydroxylase
The present invention relates to oleate hydroxylase genes, proteins, and methods of their use. The present invention also relates to methods of using the oleate hydroxylase genes and proteins,...
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6972186 |
Nucleic acid encoding pro 1410 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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6972185 |
Nucleic acids encoding PRO844 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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6969611 |
Methods to prepare cells comprising heterologous polyketide synthase expression systems
Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described...
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6969596 |
Polynucleotide encoding a human receptor tyrosine kinase
An isolated and purified human receptor tyrosine kinase is described. A cDNA sequence which encodes the native polypeptide is disclosed as well as the structural coding region and the amino acid...
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6967080 |
Proteins with changed epitopes and methods for the production thereof
The present invention relates to methods for modifying proteins by mapping one or more epitopes of the protein and altering the amino acid sequence of one or more epitopes of the protein in order...
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6964866 |
Methods and compositions for highly efficient transformation of filamentous fungi
Applicants have devised a highly effective, convenient, and expeditious genetic transformation system for filamentous fungi, such as Agaricus bisporus . The preferred method uses an Agrobacterium...
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6964845 |
Thermostable phage lambda operator mutants for regulating gene expression
The present invention concerns a method for selecting New P R or P L operator sequences from lambdoid phages which have different thermostability compared to the wild-type sequence with regard to...
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6962805 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having improved amino acid or nucleic acid productivity comprising the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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6962794 |
Application of glucose transport mutants for production of aromatic pathway compounds
This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being...
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6960453 |
Hybrid polyketide synthases combining heterologous loading and extender modules
A hybrid type I polyketide synthase gene typically containing a starter module and a plurality of heterologous extender modules is used to synthesize novel polyketides. It is preferably under the...
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6958215 |
Methods and compositions for inhibition of RNA splicing
A method of inhibiting the self-splicing of a Group I intron is disclosed. The method uses an oligonucleotide having a sequence essentially identical to a guide sequence found in the 5′ flanking...
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6955807 |
IL-2 selective agonists and antagonists
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or...
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6953672 |
Screen for CDC7 inhibitors
Disclosed is a yeast cell whose genetic complement includes an inactive allele of the yeast CDC7 gene, a first nucleic acid that encodes a mammalian Cdc7 protein, and a second nucleic acid that...
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6949363 |
Polynucleotides encoding novel human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and...
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6949345 |
Identification and cloning of a mycobacterial antigen corresponding to a heparin-binding haemagglutinin
The present invention relates to peptide sequences enabling mycobacteria to adhere to host cells (e.g., epithelial cells). More particularly, the invention relates to a mycobacterial...
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6949366 |
Cytokines that bind the cell surface receptor hek
Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek)...
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6949356 |
Methods for improving secondary metabolite production in fungi
The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by...
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6949357 |
Reagents and methods useful for detecting diseases of the urinary tract
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are...
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6939676 |
Selection procedure for identifying transgenic cells, embryos, and plants without the use of antibiotics
Transgenic cells may be selected using temperature sensitive marker proteins. In this method, a population of host cells are transformed with a foreign DNA construct which includes at least one...
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