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7101698 |
Alkaline protease
The present invention relates to an alkaline protease having a prepro sequence, wherein the prepro sequence is a mutant sequence of the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence...
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7101689 |
Interleukin-18 binding proteins, their preparation and use
Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs...
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7098002 |
Preparation of biologically active molecules
Biologically active molecules are produced from their biologically inactive precursors by mutation of their native cleavage site to a site which is capable of being cleaved by a protease, and...
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7098379 |
Plant UDP-glucose dehydrogenase
This invention relates to an isolated nucleic acid fragment encoding a hemicellulose biosynthesis protein. The invention also relates to the construction of a chimeric gene encoding all or a...
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7094585 |
Glucose dehydrogenase β-subunit and DNA encoding the same
A DNA fragment encoding a β subunit is obtained by inverse PCR using primers designed based on the nucleotide sequence of a N-terminal signal sequence region of a GDH β subunit derived from ...
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7091003 |
Polypeptides having phospholipase B activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having phospholipase B activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid...
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7091319 |
IL-3 variant hematopoiesis fusion protein
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
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7090994 |
Methods of screening for introduction of DNA into a target cell
The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important...
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7090980 |
Method of detecting acid-fast bacteria using ribosomal RNA as target
A method of detecting a specific acid-fast bacterium, wherein primers having nucleotide sequences homologous or complementary to the specific regions in the rRNAs of the specific acid-fast...
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7087432 |
Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase...
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7083946 |
PRO1343 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7083794 |
Recombinant vaccines comprising immunogenic attenuated bacteria having RpoS positive phenotype
Attenuated immunogenic bacteria having an RpoS + phenotype, in particular, Salmonella enterica serotype Typhi having an RpoS + phenotype and methods therefor are disclosed. The Salmonella ...
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7083952 |
Nucleotide sequences coding for proteins involved in the biosynthesis of L-serine, an improved method for the microbial production of L-serine and a genetically modified microorganism suitable therefor
The present invention relates to nucleotide sequences of coryneform bacteria, coding for proteins involved in the bio-synthesis of L-serine and to methods for the isolation thereof. The invention...
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7081341 |
Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance
Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would...
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7078027 |
Human endokine alpha
The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha...
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7078190 |
Compositions and methods utilizing the yeast ZE01 promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7078389 |
Chemically modified oligonucleotide for site-directed mutagenesis
A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid...
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7074584 |
Yeast arrays, methods of making such arrays, and methods of analyzing such arrays
This patent describes a novel method of detecting genetic interactions in yeast. This method can also be used to screen for function of biological effectors on yeast. The method encompasses...
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7074592 |
Secreted and transmembrane polypeptides nucleic acid encoding
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7074591 |
Polynucleotides encoding human GABA receptors
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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7070989 |
Escherichia coli strain secreting human granulocyte colony stimulating factor (G-CSF)
The present invention provides a recombinant plasmid vector comprising a kanamycin resistance gene, a promoter, an endoxylanase signal sequence, a nucleotide sequence coding for an oligopeptide...
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7071315 |
Alleles of the human mu opioid receptor, diagnostic methods using said alleles, and methods of treatment based thereon
Provided herein are variant alleles of a gene encoding a mu opioid receptor, along with cloning vectors for replicating such variant alleles, expressing vectors for expressing the variant alleles...
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7067624 |
Antimicrobial proteins
A new family of antimicrobial proteins is described. Prototype proteins can be isolated from Macadamia integrifolia as well as other plant species. DNA encoding the protein is also described as...
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7067284 |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin...
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7063965 |
Nucleic acid encoding TIE-2 ligand
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptorbody which specifically binds a human TIE-2...
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7063950 |
Nucleic acids encoding human calcium channel and methods of use thereof
Isolated DNA encoding each of human calcium channel α 1 -, α 2 -, β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors...
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7060467 |
Recombinant proteins containing repeating units
Methods for the production of recombinant proteins containing repeating units are disclosed. Also disclosed are methods for the production of degenerate polynucleotides encoding said recombinant...
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7060875 |
Methods for delaying leaf senescence using the ORE7 gene
The present invention relates to a gene regulating leaf longevity of plants and a method for regulating the longevity of plants using the same. More particularly, it relates to a ORE7 gene...
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7060261 |
Chemokine α-5
The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5...
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7060499 |
DNA containing variant FRT sequences
To provide DNA comprising mutant FRT sequence which causes recombination reaction between two mutant FRT sequences having an identical sequence to each other but does not cause recombination...
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7056698 |
Nucleic acids encoding interleukin-9 receptor variants
This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One...
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7056728 |
Compositions and methods for use thereof in modifying the genomes of microorganisms
The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other...
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7052889 |
Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
Murine and human Suv39h2 polypeptide and DNA molecules encoding them. Suv39h2 is a novel member of the Suv3-9 gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has...
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7049096 |
Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1
The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding...
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7049401 |
Human histamine receptor of the H3 subtype
DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have...
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7049145 |
Vaccinia virus MVA-E3L-knockout-mutants and use thereof
The present invention relates to mutant MVA vaccinia viruses, which are used for the generation of recombinant MVA viruses, as well as host cells, which have been infected with these mutant MVA...
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7049117 |
Mutant possessing uracil phosphoribosyl transferase activity
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence...
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7041474 |
Nucleic acid encoding human tango 509
The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and...
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7041477 |
Production of heterologous proteins from Zygosaccharomyces bailii
The invention refers to the production of recombinant gene products from cultures of the yeast Zygosaccharomyces bailii strains transformed with expression vectors bearing the gene coding for...
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7041471 |
Carotene hydroxylase and method for producing xanthophyll derivatives
The present invention relates to proteins which have an enzymatic activity for converting β-carotene into zeaxanthin or canthaxanthin into astaxanthin, to nucleic acids which encode these...
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7037675 |
Nucleic acid molecules encoding SIGIRR polypeptides
The invention is directed to purified and isolated SIGIRR polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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7033789 |
DNA molecules encoding L-glutamate-gated chloride channels from Schistocerca americana
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Schistocerca americana (grasshopper) glutamate-gated chloride channels. The present...
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7033783 |
Polynucleotide encoding IL-1 zeta polypeptide
The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of...
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7033818 |
Recombinant polyketide synthase genes
Regions of sequence identity are recurrent in some modular polyketide synthase (PKS) gene clusters. Such sequences are potentially detrimental to the stability of PKS gene clusters and expression...
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7033787 |
Isolated cytokine receptor LICR-2
The invention relates to new members of the Class II cytokine receptor family, such as LICR-2. The new member binds to AK155, and mediates STAT activation.
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7033785 |
PRO1347 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7033786 |
Pro1340 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7029873 |
Nucleic acids to PRO1387 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7029870 |
Gabaa receptor epsilon subunits
The present invention relates to a novel GABA A receptor ε subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding...
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7029685 |
Plasmodium falciparum AMA-1 protein and uses thereof
In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified...
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