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6773882 |
Polynucleotide probes for detection and quantitation of candida species
Hybridization probes and accessory oligonucleotides useful for detecting ribosomal nucleic acids from Candida albicans, Candida tropicalis, Candida dubliniensis, Candida viswanathii and Candida...
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6770476 |
Radiation resistant bacterium/E. coli shuttle vector
The endogenous plasmid pUE30 from radioresistant bacterium D. radiopugnans strain ATCC19172 or a derivative thereof is used as a vector that can autonomously replicate in bacteria of the genus...
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6770481 |
Gene isolation method
A plasmid vector characterized by comprising a promoter sequence that can be recognized by an RNA polymerase which is not inherent in a host and that controls the expression of desired genes and a...
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6770464 |
Methods for producing poly(hydroxy) fatty acids in bacteria
The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy...
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6767536 |
Recombinant Staphylococcus thioredoxin reductase and inhibitors thereof useful as antimicrobial agents
Isolated and purified Staphylococcus thioredoxin reductases (TrxB) are provided. Polynucleotides encoding the TrxBs, vectors and host cells containing such polynucleotides are also provided. In...
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6767743 |
Method and an apparatus for generating shockwave, a method and an apparatus for accelerating particles, an apparatus for delivering drugs, and a method and an apparatus for delivering DNA
Method and apparatus for accelerating micro particles for use in delivering DNA or a solid drug in which a shockwave is generated by applying a short pulse energy to a surface of a metal foil to be...
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6768001 |
Xylanase from trichoderma reesei, method for production thereof, and methods employing this enzyme
The present invention is directed to novel xylanases (referred to as XYL-IV) and to nucleic acid molecules encoding those xylanases. Also provided herein are vectors and host cells including those...
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6767533 |
Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress
A composition containing a peripheral benzodiazepine receptor ligand for topical use in the treatment of cutaneous stress.
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6764837 |
Agrobacterium tumefaciens rpoA gene
The present invention is directed to a method for expression of at least one heterologous gene in a host cell comprising transforming a host cell with at least one nucleic acid construct comprising...
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6764674 |
Adenovirus E1B shuttle vectors
Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, and optionally the substitution...
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6762040 |
Method for increasing gene copy number in a host cell and resulting host cell
The invention relates to a method for increasing the copy number of a chromosomally integrated expression cassette in a microbial strain without leaving antibiotic resistance markers behind in the...
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6759231 |
Phage with nuclear localization signal
A λ phage with a nuclear localization signal has been obtained by constructing a vector capable of expressing a fused protein between a gpD protein constituting the head of a λ phage and a...
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6759514 |
Transporter polypeptide and method of producing same
Novel genes significantly homologous to organic cation transporters OCT1 and OCT2 have been successfully isolated by screening a fetal gene library by random sequencing. Proteins encoded by these...
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6759223 |
Calcium/calmodulin-dependent kinase
The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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6756483 |
Method and substances for diagnosis and therapy of sepsis and sepsis-like systemic infections
Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in...
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6753164 |
Nucleic acids encoding human serpin polypeptide HMCIS41
The present invention relates to novel human Serpin polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host...
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6750059 |
Archiving of vectors
The invention relates to a solid medium or matrix for storage of nucleic acid molecules (e.g. RNA and/or DNA), particularly vectors and especially plasmids, comprising a solid matrix preferably...
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6749847 |
Hybrid cytokine of IL-7 and β-chain of hepatocyte growth factor
A hybrid cytokine comprising the B-chain of hepatocyte growth factor and IL-7, linked by a linker molecule, having pre-pro-B growth stimulating activity.
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6750333 |
Process for preparing purified nucleic acid and the use thereof
The invention relates to a nucleic acid preparation with a content of below 1% protein, preferably below 0.1% protein, free of ethidium bromide, phenol, caesium chloride and detergents based on...
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6747131 |
Phosphorylated fusion proteins
Modified proteins, modified interferons α's and β's, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-α-like...
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6746870 |
DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use...
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6746671 |
Use of a cytokine-producing lactococcus strain to treat colitis
An administration strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, for example, IL10 and/or soluble...
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6743903 |
Nucleic acids for the diagnosis and treatment of giant cell arteritis
This invention provides nucleic acids and methods for making and using them. The compositions and methods of the invention are used to diagnose and treat Giant Cell Arteritis (GCA).
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6743584 |
Molecular-biological marker for analytical electron microscopy
The invention relates to plasmids derived from pBluescript KS(+), which contains more than 1, preferably 2, 7, 14, 21 and 27, respective SK primer elements, and their use in analytical electron...
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6740504 |
Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically...
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6737252 |
7 transmembrane receptor family member BLRX
Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are...
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6737269 |
Multi-state genetic oscillator
Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant multi-state genetic oscillators containing an adjustable-threshold genetic switch...
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6733761 |
Mycobacterial isocitrate lyase gene and uses thereof
The present invention provides a purified and isolated nucleic acid encoding mycobacterial isocitrate lyase, as well as mutated forms of the nucleic acid. Further provided are purified and isolated...
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6734343 |
Rhamnosyl-transferase gene and uses thereof
An isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide having a flavanone-7-O-glucoside-2″-O-rhamnosyl-transferase catalytic activity and its uses.
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6733990 |
Nucleic acid encoding 15571, a GPCR-like molecule of the secretin-like family
Novel GPCR-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GPCR-like proteins, the invention further provides isolated GPCR-like fusion...
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6730499 |
Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1
The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable...
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6727353 |
Nucleic acid encoding Kv10.1, a voltage-gated potassium channel from human brain
The invention provides isolated nucleic acid and amino acid sequences of Slo potassium family members such as, antibodies to Kv10 subfamily members such as Kv10.1, methods of detecting Kv10,...
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6727095 |
Nucleotide sequences encoding sugarbeet glutamine synthetase and methods for reducing glutamine metabolism in sugarbeet
The present invention relates to agents and methods for modifying the glutamine metabolism in plants, especially in sugar beet.
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6727085 |
Subtilase variants having an improved wash performance on egg stains
The present invention relates to the use of a subtilase variant for removal of egg stains from laundry or from hard surfaces, where the subtilase variant comprises at least one additional amino...
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6723323 |
Vibrio Cholerae vaccine candidates and method of their constructing
Vibrio cholerae vaccine strains which have a disrupted hap gene and which are tagged with celA coding functions from Clostridium thermocellum are described. A contained, genetically defined thyA...
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6723521 |
Method for screening compounds which modulate glucose transporting activity
A gene hucep-8 coding for a novel protein HUCEP-8 having sugar-transporting activity can be obtained by cloning from a cDNA library derived from human cerebral cortex.
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6720167 |
Insecticidal bacteria, and methods for making and using them
The invention relates to the discovery that nucleic acid sequences comprising a BtI or BtII promoter, or a combination of a BtI and a BtII promoter, a bacterial STAB-SD sequence, and a sequence...
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6716604 |
Nucleic acid molecules encoding a subunit of a human calcium/calmodulin-dependent protein kinase
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically...
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6716603 |
Nucleic acids encoding a chloride channel protein
A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy,...
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6713288 |
Whole cell catalysts
A microorganism is described which is transformed with DNAs which encode a hydantoinnase, a racemase, and a carbamoylase. As a result, the microorganism is able to degrade hydantoins directly to...
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6713289 |
Nucleotide sequences which code for the eno gene
The present invention is directed to nucleotide sequences coding for a bacterial enolase enzyme. These sequences may be used in improved methods for the fermentative preparation of amino acids...
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6706503 |
Directed evolution of microorganisms
The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses...
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6706525 |
Highly transformable bacterial cells and methods for producing the same
The invention provided herein includes novel gram negative bacteria cells containing the Hte mutation. Other aspects of the invention include methods for rendering gram negative bacterial cells...
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6703495 |
Polynucleotides encoding human transporter protein
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6700038 |
Plant expression vectors based on the flock house virus genome
The invention provides insect viral vectors useful to transfer genes to plants, insects and other hosts.
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6699702 |
Prokaryotic system designed to monitor protease activity
The invention relates to a prokaryotic cell system for monitoring protease activity. The invention also includes assays for identifying protease inhibitors and protease modulators, determining the...
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6696278 |
Method for transfer of DNA segments
The present invention provides a method of transfer of a gene of interest from a first vector to a product vector comprising contacting a first and second vector in vitro with a site-specific...
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6696282 |
Fusarium sporotrichioides strains for production of lycopene
The instant invention is drawn towards transformed strains of Fusarium sporotrichioides effective for the production of lycopene. The transformed strains comprise an expression cassette having...
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6696293 |
Process for producing carotenoids and biological materials useful therefor
A process for producing carotenoids, which involves cultivating a microorganism obtained by treating a parent microorganism that produces carotenoids under conditions that induce a reduction in...
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6692735 |
Variant of C6 β-chemokine leukotactin-1(shLkn-1) with enhanced biological activity
The present invention relates to a variant of Lkn-1(shLkn-1) with enhanced biological activity, which is a truncated form of Lkn-1, a process for preparing a recombinant shLkn-1 by employing...
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