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7608752 |
Gene targeting using replicating DNA molecules
The invention provides novel methods of gene targeting using replication in order to increase the efficiency of targeted genetic modification in an eukaryotic organism. Included are vectors,...
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7604995 |
Compositions, kits, and methods for stimulation of homologous recombination
A method of stimulating homologous recombination by creating at least one nick in a targeted polynucleotide sequence. Wherein nonhomologous recombination is suppressed resulting in increasing the...
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7592502 |
Knock-in non-human animal producing human tissue factor
A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been...
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7556929 |
Compositions and methods for screening anti-cancer agents in yeast
Methods and kits for identifying novel anti-tumor agents are provided.
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7510857 |
Thermostable cellulase and methods of use
A Clostridium thermocellum thermostable cellulase enzyme with both endocellulase activity and exocellulase activity that is able to degrade cellulose in the absence of scaffolding and other...
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7473557 |
Method for targeting transcriptionally active loci
The present invention provides a method of achieving very high targeting efficiency by utilizing targeting vectors that utilize promoter-less selection cassettes and which are engineered to...
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7449179 |
Vectors for conditional gene inactivation
A method of preparing gene trapping libraries, and gene targeted cells for conditional inactivation of genes, is provided. The invention provides a vector having a mutational element cassette and a...
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7435591 |
Compositions and methods for increasing animal size growth rate
The present invention relates to germ line and somatic cells comprising a mutant p27 kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making...
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7410799 |
In vivo production and delivery of erythropoietin or insulinotropin for gene therapy
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes...
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7399901 |
Mutated gene coding for a lat protein and the biological applications thereof
The present invention relates to a mutated gene coding for a mutant LAT protein leading to exaggerated T H 2 differentiation. The invention relates to biological structures containing the mutant,...
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7361754 |
Genetically purified gellan gum
Mutational inactivation of proteins involved in para-cresol production in certain milk products results in improved taste and odor. The undesirable para-cresol forms over time as a result of...
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7309605 |
Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful...
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7303894 |
Detection of phenols using engineered bacteria
Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate...
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7294500 |
Mosaic infectious bursal disease virus vaccines
The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable...
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7285700 |
Plastid directed DNA constructs comprising chimeric plastid targeting regions, vectors containing same and methods of use thereof
This invention relates to methods and compositions for obtaining Arabidopsis and Brassica plants. Specifically, the method provides culturing protocols and compositions that facilitate the...
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7279334 |
Methods for inducing targeted stimulation of meiotic recombination and kits for performing said methods
The Invention pertains to methods, kits, molecules and cells to increase the rate or recombination and/or target recombination in dividing cells. In a particular aspect, the invention concerns...
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7271000 |
Nucleotide sequence encoding the enzyme I-Scel and the uses thereof
An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful...
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7250556 |
Transposable elements in rice and methods of use
Disclosed are isolated transposable elements, or isolated DNA sequences which encode a transposase protein or a portion of a transposase protein. The isolated transposable elements or the isolated...
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7250293 |
Complementing cell lines
A packaging cell line capable of complementing recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived from primary diploid...
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7223390 |
Insertion of furin protease cleavage sites in membrane proteins and uses thereof
Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual...
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7220542 |
Expression cloning in filamentous fungi
Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are...
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7214532 |
Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof
The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of...
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7201899 |
Materials and methods for management of hyperacute rejection in human xenotransplantation
Human pre-formed xenoantibodies play an important role in the hyperacute rejection response in human xenotransplantation. Disclosed are materials and methods for removing or neutralizing such...
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7196187 |
Method for producing antibody fragments
An expression library comprising a repertoire of nucleic acid sequences cloned from a non-immunised source, each nucleic acid sequence encoding at least part of a variable domain of a heavy chain...
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7173105 |
Nucleotide sequences coding for the LuxR gene
The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for...
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7164056 |
Gene targeting using replicating DNA molecules
The invention provides novel methods of gene targeting using replication in order to increase the efficiency of targeted genetic modification in an eukaryotic organism. Included are vectors,...
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7144734 |
Enhanced homologous recombination mediated by lambda recombination proteins
Disclosed herein are methods for generating recombinant DNA molecules in cells using homologous recombination mediated by recombinases and similar proteins. The methods promote high efficiency...
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7138262 |
High mannose proteins and methods of making high mannose proteins
The invention features a method of producing a high mannose glucocerebrosidase (hmGCB) which includes: providing a cell which is capable of expressing glucocerebrosidase (GCB), and allowing...
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7135620 |
Genetic engineering of plant chloroplasts
Novel chimeric constructions and methods for their use are provided for expression of exogenous genes in a plant chloroplast. Particularly, expression is achieved by the use of a chloroplast or...
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7129391 |
Universal chloroplast integration and expression vectors, transformed plants and products thereof
The invention provides universal chloroplast integration and expression vectors which are competent to stably transform and integrate genes of interest into chloroplast genome of multiple species...
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7129084 |
Production of humanized antibodies in transgenic animals
This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more...
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7122312 |
Methods for drug target screening
The present invention provides methods for identifying targets of a drug in a cell by comparing (i) the effects of the drug on a wild-type cell, (ii) the effects on a wild-type cell of...
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7105348 |
Methods of modifying eukaryotic cells
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells....
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7081561 |
Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further...
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7060500 |
Single-stranded oligodeoxynucleotide mutational vectors
The invention concerns the introduction of predetermined genetic changes in target genes of a living cell by introducing an oligodeoxynucleotide encoding the predetermined change. The...
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7045675 |
Genes for Niemann-Pick type C disease
A gene for type C Niemann-Pick disease (NP-C) is disclosed, along with the amino acid sequence of the encoded peptide. Applications which are made possible by the present invention include...
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7026164 |
Adenovirus packaging cell lines
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus...
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7005299 |
Expression of heterologous genes according to a targeted expression profile
A gene trap vector comprises a DNA construct containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is used in gene...
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6939712 |
Muting gene activity using a transgenic nucleic acid
The invention provides compositions and methods for muting expression of an endogenous gene in an animal cell, the muting resulting from providing a transgene to a cell. Expression of which...
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6936470 |
Rapid and enzymeless cloning of nucleic acid fragments
A method for cloning a nucleic acid fragment into a vector by flanking the fragment with first and second adapter sequences, and contacting the fragment with the vector having sequences homologous...
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6936418 |
Methods and compositions for effecting homologous recombination
This invention concerns a method for effecting directed mutagenesis based on a guided homologous recombination system that comprises (i) a triple helix forming oligonucleotide, (ii) a donor nucleic...
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6933422 |
Nav2 channel gene-deficient mice
An object of the present invention is to provide a null mutant non-human animal showing salt intake behavior similar to that of wild-type animals under water-sufficient conditions and showing much...
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6897020 |
Methods and compositions for elucidating relative protein expression levels in cells
The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly...
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6891081 |
Transgenic mice over-expressing amyloid-beta alcohol dehydrogenase (ABAD) in brain as model of alzheimer's disease and uses thereof
The present invention provides for a transgenic non-human animal whose cells contain a recombinant DNA sequence comprising a nerve tissue specific promoter operatively linked to a DNA sequence...
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6884622 |
Method for preparing a mammalian cell deficient in HPRT
The method of the invention provides the use of a replacement-type targeting construct to delete large fragments of genomic DNA by gene targeting. The replacement targeting construct, which may...
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6855513 |
Quorum sensing signaling in bacteria
The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention...
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6830920 |
Rapid generation of recombinant adenoviral vectors
The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention...
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6830892 |
Lentiviral vector system for high quantity screening
A method of screening for a target molecule from a group of potential target molecules is described. This method involves using a library of lentiviral vectors where the members encode the group of...
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6818209 |
Retroviral delivery system
A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope...
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6781032 |
Homologous recombination in plants
The present invention provides novel methods for modifying target nucleotide sequences in a plant cell through the use of homologous recombination. The plant cell is transformed with a DNA...
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