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7625755 Conditional knockout method for gene trapping and gene targeting using an inducible gene silencer  
A method for conditionally knocking out and altering gene function and genetic sequences that can be used in such methods, for use in gene trapping and gene targeting. Specifically, the genetic...
7531522 Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi  
A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the...
7521240 Chromosome-based platforms  
Artificial chromosomes, including ACes, that have been engineered to contain available sites for site-specific, recombination-directed integration of DNA of interest are provided. These artificial...
7517688 Method for ligating nucleic acids and molecular cloning  
The invention provides cells and methods of circularizing linear DNA molecules. The cell is an isolated Escherichia coli cell which transiently expresses the Cre recombinase protein from an...
7491539 Sequence specific DNA recombination in eukaryotic cells  
The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at...
7473557 Method for targeting transcriptionally active loci  
The present invention provides a method of achieving very high targeting efficiency by utilizing targeting vectors that utilize promoter-less selection cassettes and which are engineered to...
7456013 Plant centromere compositions  
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve...
7361641 Methods and compositions for genomic modification  
The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of...
7351877 Lambda integrase mediated recombination in plants  
The present disclosure provides methods for obtaining the targeted integration of a DNA molecule into the genome of a host cell using a recombinase. The methods disclosed herein can be used with a...
7309605 Nucleotide sequence encoding the enzyme I-SceI and the uses thereof  
An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful...
7304222 Inbred corn line PHENE  
A novel inbred maize line designated PHENE and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHENE with another maize plant....
7297850 Inbred corn line PHAPT  
A novel inbred maize line designated PHAPT and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHAPT with another maize plant....
7276352 Induction of β cell differentiation in human cells by stimulation of the GLP-1 receptor  
The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1...
7273757 Recombinant vector containing MJ1 gene and method of site-specific integration using the same  
The present invention relates to a recombinant vector comprising MJ1 gene coding an integrase derived from Enterococcus temperate bacteriophage φ FC1 and an integration method using the vector....
7273973 Inbred corn line PHEHG  
A novel inbred maize line designated PHEHG and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHEHG with another maize plant....
7271327 Hybrid maize plant and seed 33Y74  
A novel hybrid maize variety designated 33Y74 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7271000 Nucleotide sequence encoding the enzyme I-Scel and the uses thereof  
An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful...
7267984 Recombination assembly of large DNA fragments  
A method of assembling large DNA fragments in a chromosome using site specific recombinases and alternating excisionases. The method may be performed in vitro or in vivo, but larger assemblies are...
7244876 Process of rapid variety-independent plant transformation  
Disclosed is a method of making transgenic plants. Heterologous DNA is first introduced into a donor plant, plant cell or protoplast, and then moved from the donor to a recipient plant, plant cell...
7238854 Method of controlling site-specific recombination  
The present invention provides methods for the conditional or regulated expression of a site-specific recombinase using split intein-mediated protein splicing. This enhances the temporal and...
7223601 Method for the integration of foreign DNA into eukaryotic genomes  
Compositions and methods for introducing a DNA of interest into a genomic target site are provided. In particular, the methods and compositions involve the use of a combination of target sites for...
7211718 Hybrid maize plant and seed 33G58  
A novel hybrid maize variety designated 33G58 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7205148 Genome mutation by intron insertion into an embryonic stem cell genome  
Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons...
7202403 Hybrid maize plant and seed 32B81  
A novel hybrid maize variety designated 32B81 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7198924 Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites  
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition...
7199294 Hybrid maize plant and seed 32H20  
A novel hybrid maize variety designated 32H20 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7196256 Hybrid maize plant and seed 37Y12  
A novel hybrid maize variety designated 37Y12 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7196255 Hybrid maize plant and seed 35F38  
A novel hybrid maize variety designated 35F38 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7164056 Gene targeting using replicating DNA molecules  
The invention provides novel methods of gene targeting using replication in order to increase the efficiency of targeted genetic modification in an eukaryotic organism. Included are vectors,...
7145056 Production of antibodies using cre-mediated site-specific recombination  
A method to produce a cell expressing an antibody from a genomic sequence of the cell comprising a modified immunoglobulin locus using Cre-mediated site-specific recombination is disclosed. The...
7141426 Altered recombinases for genome modification  
The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the...
7132290 Recombinase-based system for combustion of adenovirus vectors  
In the present invention, viruses, plasmids or both are constructed which contain viral DNA and lox sites positioned such that site-specific recombination between lox sites in separate plasmids...
7122715 In vitro method to create circular molecules for use in transformation  
The present invention relates generally to transgenic plants. More specifically, it relates to methods and compositions for the introduction of DNA using circular molecules that are not able to...
7112721 Methods and constructs for plant transformation  
The present invention relates to novel methods for the transformation of crop species, novel methods for the selection and identification of transformed plant cells and novel methods for recovery...
7109178 Method for ligating nucleic acids and molecular cloning  
The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector...
7102055 Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant  
Methods for the targeted integration of nucleotide sequences into a plant are provided. Transfer cassettes comprising nucleotide sequences of interest flanked by non-identical recombination sites...
7087821 Hybrid maize 33Y45  
A novel hybrid maize variety designated 33Y45 and seed, plants and plant parts thereof, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7087823 Hybrid maize X0923B  
A novel hybrid maize variety designated X0923B and seed, plants and plant parts thereof, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7083980 Tn5 transposase mutants and the use thereof  
Tn5 transposase (Tnp) mutants that have higher transposase activities than the wild-type Tnp are disclosed. The Tn5 Tnp mutants differ from the wild-type Tnp at amino acid positions 54, 242, and...
7078603 Hybrid maize 32R38  
A novel hybrid maize variety designated 32R38 and seed, plants and plant parts thereof, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7067284 Methods for producing antibody libraries using universal or randomized immunoglobulin light chains  
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin...
7053284 Hybrid maize 34B39  
A novel hybrid maize variety designated 34B39 and seed, plants and plant parts thereof, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
7033744 Method for proliferating a liver cell, a liver cell obtained thereby, and use thereof  
The present invention provides a method comprising a step of transferring a cell proliferation factor gene into a mammalian liver cell to obtain an immortalized liver cell, a step of proliferating...
7026164 Adenovirus packaging cell lines  
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus...
6995010 Gene transfer method  
A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a...
6974694 Adenoviruses for control of gene expression  
The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected...
6953689 Cloning system for construction of recombinant expression vectors  
Cloning systems are provided for constructing expression vectors. In one aspect of the invention, a kit is provided for constructing one or more recombinant expression vectors. The kit comprises: a...
6936418 Methods and compositions for effecting homologous recombination  
This invention concerns a method for effecting directed mutagenesis based on a guided homologous recombination system that comprises (i) a triple helix forming oligonucleotide, (ii) a donor nucleic...
6933146 Methods and means for producing efficient silencing construct using recombinational cloning  
Methods and vectors and kits are provided for producing chimeric nucleic acid constructs capable of producing dsRNA for silencing target nucleic acid sequences of interest using recombinational...
6838285 Site specific recombinase based method for producing adenoviral vectors  
Site-specific recombinase based methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In...
Matches 1 - 50 out of 113 1 2 3 >