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7544670 |
HoxD3, HoxA3 and HoxB3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7482319 |
Vault and vault-like carrier molecules
A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like...
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7449449 |
Particle-mediated transformation of vertebrate tissue cells
A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the...
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7422861 |
Oligonucleotide transfection screening method
Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can...
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7402573 |
Use of nanoparticles for the DNA administration to a target organ
The invention relates to the use of DNA-loaded nanoparticles for a transfection of DNA into cells in vitro or in vivo.
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7402435 |
Method of transferring a selected molecule into a cell
A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold...
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7358234 |
Induction of a protective immune response through microprojectiles coated with a DNA sequence encoding an immunogenic protein
The present invention relates to a process for inducing a protective immune response in a mammal against a virus, in which a construct including a promoter and a DNA sequence encoding a protein or...
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7344887 |
Methods and products for delivering biological molecules to cells using multicomponent nanostructures
This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired...
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7332339 |
Transferring materials into cells using porous silicon
Porous and/or polycrystalline silicon are used in the delivery of substances into cells. The porous and/or polycrystalline silicon can be formed into micropiercers, microneedles and biolistic...
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7279322 |
Electrospraying apparatus and method for coating particles
An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser...
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7176186 |
Stimulation of cell-mediated immune responses by targeted particulate genetic immunization
The present invention relates to various methods of genetic immunization for the purpose of providing antigen-specific immunity in a mammalian host, including a human host. The invention is based...
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7132289 |
Method for introducing foreign matters into living cells
A method for introducing a foreign matter into a cell, includes the steps of placing a small particle carrying a foreign matter at a part of a cell surface of a living cell, boring a hole in a cell...
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7115582 |
HoxD3 and HoxA3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7105052 |
Ordered array of magnetized nanorods and associated methods
An ordered array of magnetized nanorods includes a plurality of metallic nanorods generally cylindrical in shape and including a nickel portion coated with a positively charged polyelectrolyte and...
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7026166 |
Fluorogenic dyes
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
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6929950 |
Microprojectile delivery system and particulate product
The invention relates to a particulate product comprising at least one microprojectile; characterized in that the or at least one of the microprojectiles comprises silicon. The invention also...
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6911586 |
Garden bean named ‘210104’
A novel garden bean cultivar, designated ‘210104’, is disclosed. The invention relates to the seeds of garden bean cultivar ‘210104’, to the plants of garden bean line ‘210104’ and to...
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6875612 |
Monocyte-specific particulate delivery vehicle
The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be...
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6870081 |
Potato cultivar FL1900
A novel potato cultivar of the genus and species Solanum tuberosum , designated FL1900, is disclosed. The invention relates to the tubers of potato variety FL1900, to the plants of potato variety...
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6869772 |
Method for labeling individual cells
A method is provided for the labeling of individual cells. Labeling is accomplished by coating a particle with at least one dye or nucleic acid sequence encoding a marker protein. The particle is...
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6770632 |
Folypolyglutamyl synthetase gene transfer to enhance antifolate
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to...
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6767743 |
Method and an apparatus for generating shockwave, a method and an apparatus for accelerating particles, an apparatus for delivering drugs, and a method and an apparatus for delivering DNA
Method and apparatus for accelerating micro particles for use in delivering DNA or a solid drug in which a shockwave is generated by applying a short pulse energy to a surface of a metal foil to be...
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6730663 |
Targeting gene expression to living tissue using jet injection
The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a complete...
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6653113 |
High efficiency gene targeting in mouse embryonic stem cells
The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications...
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6642003 |
Human glucose-dependent insulin-secreting cell line
Disclosed herein is a novel cell line of human pancreatic cells that secrete insulin in a glucose-dependent manner. The cell line comprises pancreatic cells, such as PANC-1 cells, which are...
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6617153 |
Portable magneto-mechanical delivery device and method for delivery of reactive substances
A method of delivery of reactive substances that are attached to magnetizable needle-like particles using a magneto-mechanical delivery device. The subject method and device can be utilized for the...
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6562376 |
DNA vaccines against poxviruses
In this application is described a poxvirus naked DNA vaccine which protects animals against poxvirus challenge comprising IMV and EEV nucleic acids from poxvirus. Methods of use of the vaccine and...
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6479285 |
p53 as a regulator of cell differentiation
The present invention involves the role of p53 in the differentiation of embryonic tissues. More particularly, the present invention provides methods of the blocking of p53 function in embryonic...
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6436709 |
Low pressure-accelerated particle gene gun
A gene gun is described wherein the contour design of the spray nozzle of the gene gun modifies the operation of the gene gun. A low pressure gas is used to accelerate the micro-particles that are...
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6406852 |
Method for preparation of microprojectiles for efficient delivery of biologicals using a particle gun
The present invention relates to a process for uniform and efficient delivery of metal projectiles into living cells and tissue of plants and animals, by bombarding the cells with biological coated...
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6369294 |
Methods comprising apoptosis inhibitors for the generation of transgenic pigs
Disclosed are methods for the isolation of primordial germ cells, culturing these cells to produce primordial germ cell-derived cell lines, methods for transforming both the primordial germ cells...
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6348338 |
Method to separate cells that have been modified with superparamagnetic particles by ballistic transfer
The ballistic transfer transfection technology employs a cold gas shock wave to accelerate microprojectiles that carry matter into cells by mechanical force. The present invention relates to a...
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6344357 |
Treating cells
Provided is a method for introducing a substance into a cell, which method comprises: (a) contacting the cell with a recognition agent to bind the recognition agent to a recognition site on the...
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6331434 |
Nitrogen-containing silicone useful for compacting nucleic acid sequences and use for transforming cells
The present invention relates to a method of transforming cells in which an appropriate quantity of nucleic acid fragments is introduced into the cells. The nucleic acid fragments are introduced in...
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6303582 |
Compositions and methods for nucleic acid delivery to the lung
A dry powder composition comprises nucleic acid constructs dispersed within with a hydrophilic excipient material, where the powder particles have an average size in the range from 0.5 μm to 50...
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6271436 |
Cells and methods for the generation of transgenic pigs
Disclosed are methods for the isolation of primordial germ cells, culturing these cells to produce primordial germ cell-derived cell lines, methods for transforming both the primordial germ cells...
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6254890 |
Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids
The present invention provides biodegradable polymer nanospheres capable of transporting and releasing therapeutic agents, specifically nucleic acids. In preferred embodiments, a sub-150 nm...
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6232113 |
Particle bombardment device
An improved particle bombardment device for transporting biological substances such as DNA into living cells. The device has a flexible barrel (40) that facilitates endoscopic particle bombardment...
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6228624 |
Method to select and transfect cell subpopulations
A method for transfecting and separating cells is disclosed. The method comprises preparing magnetic particles coated with genetic material and a cell-specific ligand, and using the particles to...
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6221666 |
Method and apparatus for cytoplasmic loading using an impact-mediated procedure
The present invention is directed to the method and apparatus for the cytoplasmic loading of macromolecules into living cells by an impact-mediated procedure that impacts the cells with a...
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6214621 |
Conjugates of a particle vector and oligonucleotides, process for their preparation, and pharmaceutical compositions containing them
The invention relates to an ionic conjugate, which is stable in a biological medium, and which is comprised of a particle vector with at least one cationic, nonliquid, hydrophilic nucleus and of...
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6200959 |
Genetic induction of anti-viral immune response and genetic vaccine for filovirus
An approach to genetic vaccine methodology is described. A genetic construction encoding antigenic determinants of a filovirus is transfected into cells of the vaccinated individuals using a...
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6194389 |
Particle-mediated bombardment of DNA sequences into tissue to induce an immune response
A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the...
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6107095 |
Method for introducing substances into living cells and tissues
A method of introducing a biological substance into living target cells, the method comprising dispersing a liquid containing the biological substance into microdroplets and propelling the...
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6020153 |
Chimeric antibodies
The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the...
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5952232 |
Expandible microparticle intracellular delivery system
The present invention relates to methods and compositions for delivery of a compound, most preferably a polynucleotide, into the cytoplasm of a cell by means of a microparticle, fabricated from a...
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5922685 |
IL-12 gene therapy of tumors
In an approach to genetic therapy for treating tumors, a genetic construction encoding the p35 and p40 subunits of the cytokine IL-12 is delivered into cells of individuals in need of therapy so as...
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5916879 |
DNA transcription unit vaccines that protect against avian influenza viruses and methods of use thereof
The present invention describes a reliably protective avian vaccine that contains a DNA transcription unit comprising a nucleic acid that encodes a viral protein. This effective and reliable avian...
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5888773 |
Method of producing single-chain Fv molecules
The invention relates to a method of producing single-chain Fv molecules in eukaryotic cells, and to secretable sFv proteins having at least one non-naturally occurring glycosylation site. The...
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5879918 |
Pretreatment of microprojectiles prior to using in a particle gun
An improvement in the process of transporting biological materials into living cells by bombarding the cells with microprojectile particles coated with biological material. In the improved process...
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