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6770632 |
Folypolyglutamyl synthetase gene transfer to enhance antifolate
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to...
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6756054 |
Polycationic sterol derivatives as transfection agents
A compound capable of acting as a cationic lipid is described. The compound comprises a cholesterol group having linked thereto a head group; wherein the head group is more positive than the head...
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6753419 |
DNA molecules encoding hormone-dependent forms of the adeno-associated virus rep proteins
The subject matters of this invention are the hormone-dependent forms of Rep 78 and Rep 68 proteins of the Adeno-associated virus (AAV), obtained by the fusion of their specific mutants with the...
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6750019 |
Antisense modulation of insulin-like growth factor binding protein 5 expression
Antisense compounds, compositions and methods are provided for modulating the expression of insulin-like growth factor binding protein 5. The compositions comprise antisense compounds, particularly...
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6749863 |
Targeted liposome gene delivery
Targeted ligand-liposome-therapeutic molecule complexes (vectors) for the systemic delivery of the therapeutic molecule to various target cell types including cancer cells such as squamous cell...
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6746868 |
Chemical modification of DNA using peptide nucleic acid conjugates
Complexes comprising a nucleic acid molecule and a conjugated peptide nucleic acid (PNA). The PNA may be labeled or conjugated to a protein, peptide, carbohydrate moiety or receptor ligand. These...
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6737561 |
Gene encoding short integuments and uses thereof
The present invention relates to the isolation and identification of a short integuments protein and the nucleic acid which encodes such protein. The invention also relates to an expression vector...
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6733777 |
Cationic reagents of transfection
Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a...
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6734171 |
Methods for encapsulating nucleic acids in lipid bilayers
The present invention relates to lipid-based formulations for nucleic acid delivery to cells, methods for the preparation of such formulations and, in particular, to lipid encapsulated plasmids....
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6692911 |
Cell delivery compositions
The present invention provides improved cell delivery compositions. In particular, the invention provides biocompatible endosomolytic agents. In a preferred embodiment, the endosomolytic agents are...
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6686199 |
Genetic manipulation of spermatogonia
The invention features a method of delivering DNA to a spermatogonium by infusing DNA in situ into a testicle of a non-human animal and administering a condition or substance to the testicle to...
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6673573 |
Expression of immunoglobulin-cytokine fusion proteins in malignant B cells
According to the invention, there is provided a vector for the expression of immunoglobulin-cytokine fusion proteins in malignant B cells at least containing operably linked to each other (a) a...
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6670129 |
Cell transfection apparatus and methods for making and using the cell transfection apparatus
A cell transfection apparatus and methods for making and using the cell transfection apparatus are described. The cell transfection apparatus has a surface on which there is printed at different...
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6656734 |
Compositions for the delivery of polynucleotides to cells
The present invention relates to a composition which is intended for transferring at least one therapeutically active substance into the interior of a target cell, characterized in that it...
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6656916 |
Glucocorticoid enhancement of gene expression
The present invention provides a method of increasing the cellular expression of a gene in a biological tissue after delivery of said gene to an animal, comprising the step of: administering to...
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6653113 |
High efficiency gene targeting in mouse embryonic stem cells
The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications...
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6642003 |
Human glucose-dependent insulin-secreting cell line
Disclosed herein is a novel cell line of human pancreatic cells that secrete insulin in a glucose-dependent manner. The cell line comprises pancreatic cells, such as PANC-1 cells, which are...
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6642207 |
Artificial chromosome constructs containing foreign nucleic acid sequences
The invention provides artificial chromosome constructs containing foreign nucleic acid sequences, such as viral nucleic acid sequences, and methods of using these artificial chromosome constructs...
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6635623 |
Lipoproteins as nucleic acid vectors
The present invention relates to materials and methods for the in vivo transport and deliver of nucleic acids. More particularly, it concerns the use of lipoproteins, including but not limited to,...
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6635483 |
Compound and methods of inhibiting or stimulating presenilin 1 and related pharmaceuticals and diagnostic agents
A compound that inhibits the cellular expression of a nucleotide sequence corresponding to all or part of the presenilin 1 gene, the compound comprising an antisense molecule comprising the...
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6632671 |
Nanoparticle encapsulation system and method
The present invention generally relates to nanocapsules and methods of preparing these nanocapsules. The present invention includes a method of forming a surfactant micelle and dispersing the...
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6630455 |
Methods for inducing mucosal immune responses
The invention provides a method of inducing a mucosal immune response in a subject, comprising administering to the mucosa of the subject an amount of antigen-encoding DNA effective to induce a...
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6627615 |
Methods and compositions for in vivo gene therapy
Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be...
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6627618 |
Materials and methods for intracellular delivery of biologically active molecules
The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a...
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6624149 |
Method for nucleic acid transfection of cells
The present invention describes methods for introducing nucleic acids into a target cell using a transition metal enhancer. A mixture containing nucleic acid and a transition metal enhancer is...
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6620795 |
Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes or nucleic acid abre...
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6613569 |
Inducible packaging cell lines for lentivirus vectors
Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of...
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6602713 |
Antisense modulation of protein phosphatase 2 catalytic subunit beta expression
Antisense compounds, compositions and methods are provided for modulating the expression of Protein Phosphatase 2 catalytic subunit beta. The compositions comprise antisense compounds, particularly...
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6589940 |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
The invention relates to immunostimulatory oligonucleotide compositions. These oligonucleotides comprise an immunostimulatory octanucleotide sequence. These oligonucleotides can be administered in...
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6576618 |
Methods to enhance wound healing and enhanced wound coverage material
The present invention describes the incorporation of liposomal gene constructs directly into a wound to further improve wound repair, or into wound coverage and/or closure materials to enhance the...
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6573101 |
Compositions for receptor/liposome mediated transfection and methods of using same
The present invention relates generally to the delivery of nucleic acid molecules into cells and, more specifically, to compositions and methods for the high efficiency delivery of nucleic acid...
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6566104 |
ERbB-4 targeted ribozymes
Enzymatic RNA molecules which cleave ErbB-4 mRNA and uses thereof.
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6559129 |
Cationic liposomal delivery system and therapeutic use thereof
The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation.
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6555673 |
Synthetic promoters
Synthetic elements for enhancing expression of genes in plant cells are disclosed. These include a promoter with a “TATA to start” sequence containing 64% or greater GC content and an synthetic...
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6555376 |
Process of entrapping genetic materials in ultra-low size nanoparticles of inorganic compounds to form non-viral carriers
The present invention relates to a process of entrapping genetic materials in nanoparticles of inorganic metal salts of size below 100 nm diameter to form non-viral carriers for delivery of genes....
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6544955 |
Method of sensitizing tumor cells with adenovirus E1A
The present invention is directed to methods of sensitizing a human tumor cell with adenovirus E1A. The methods involve treating a human tumor cell by, first, introducing into the tumor cell...
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6544797 |
Compositions and methods for inhibiting light-induced inactivation of biological reagents
Disclosed is a fluorescent conjugate comprising a biological reagent, a fluorescent molecule, and a means for impeding phototoxic degradation of the biological reagent. The impeding means can be a...
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6534483 |
Protected one-vial formulation for nucleic acid molecules, methods of making the same by in-line mixing, and related products and methods
The present invention, as noted above, relates generally to the incorporation of plasmid into a conventional dosage form, and more particularly to the production of a single-vial, homogenized,...
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6528312 |
Use of G-actin for improving transfection of a polynucleotide into a cell
Described is the use of a nuclease inhibitor or of interleukin-10 (IL-10) for the preparation of a therapeutic composition for improving transfection of a polynucleotide into a cell, and to...
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6524815 |
VE-cadherin promoter and its uses
The invention relates to the isolation and cloning of the VE-cadherin promoter. It also relates to transformed cells and transgenic animals containing the VE-cadherin promoter. The VE-cadherin...
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6521252 |
Transfecting compounds which are sensitive to reducing conditions, pharmaceutical compositions containing them and their applications
The invention concerns a novel agent for transferring nucleic acids into cells. Said agent is particularly characterised in that it comprises one or several disulphide bonds sensitive to reducing...
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6521455 |
Nucleic acid molecule encoding a transport protein
The present invention relates to transport proteins, in particular VP22 and homologues thereof, and to methods of delivering these proteins and any associated molecules to a target population of...
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6518413 |
Utrophin gene expression
Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic...
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6503533 |
Antisense ogligonucleotides against Hepatitis B viral replication
Antisense oligonucleotides that hybridize to segments of the pres1, S, C, and ε regions of the hepatitis B virus (HBV) RNA pregenome inhibit replication of the virus. Pharmaceutical compositions...
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6503756 |
Antisense modulation of syntaxin 4 interacting protein expression
Antisense compounds, compositions and methods are provided for modulating the expression of Syntaxin 4 interacting protein. The compositions comprise antisense compounds, particularly antisense...
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6475735 |
Human BMP-2 promoter and method for exploring bone-related substance by using the same
The present invention provides a method for exploring low molecular weight compounds which regulate positively or negatively the expression of the human BMP-2 with reference to a reporter activity...
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6468985 |
Retinoblastoma protein-interacting zinc finger proteins
The present invention provides mammalian retinoblastoma (Rb) protein-interacting zinc finger (RIZ) proteins, nucleic acid molecules encoding the RIZ and antibodies specific for the RIZ. The...
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6468798 |
Expression of cloned genes in the lung by aerosol and liposome-based delivery
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Liposome-nucleic acid complexes are prepared then delivered...
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6458026 |
Integrin-targeting vectors having transfection activity
A complex that comprises (i) a nucleic acid, (ii) an integrin-binding component, for example, an integrin-binding peptide, (iii) a polycationic nucleic acid-binding component, for example,...
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6458593 |
Immortalized cell lines and methods of making the same
The present invention relates to methods of immortalizing various primary cell cultures, including pituitary cells, neurons, beta islet cells, glial cells, corneal epithelial cells and follicular...
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