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7105157 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
The present invention relates to cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells...
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7101995 |
Compositions and processes using siRNA, amphipathic compounds and polycations
Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal...
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7098032 |
Compositions and methods for drug delivery using pH sensitive molecules
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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7098030 |
Polyampholytes for delivering polyions to a cell
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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7098191 |
Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other genes of interest in mammalian cells are provided, as well as methods of using the...
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7094605 |
Formation of polyampholytes in the presence of a polyion
Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to...
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7091041 |
Micellar systems
A complex is described that is deliverable to a cell comprising inserting a nucleic acid or other cargo into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for...
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7087585 |
Tripeptide of FcγRIIA
The present invention relates, in general, to phagocytosis and phagolysosomal fusion and, in particular, to a tripeptide of FcγRIIA that mediates trafficking of targets phagocytosed via FcγRIIA...
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7087770 |
Compound containing a labile disulfide bond
A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
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7070807 |
Branched histidine copolymers and methods for using same
The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport...
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7067697 |
Cationic liposomes for gene transfer
The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells.
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7060500 |
Single-stranded oligodeoxynucleotide mutational vectors
The invention concerns the introduction of predetermined genetic changes in target genes of a living cell by introducing an oligodeoxynucleotide encoding the predetermined change. The...
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7060689 |
Methods and compositions for delivery and retention of active agents to lymph nodes
The present invention is directed to delivery and retention of active agents to targeted lymph nodes in a mammal using a ligand/anti-ligand pair. More particularly, the invention involves methods,...
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7056897 |
Inducible expression vectors and methods of use thereof
The present invention relates to inducible gene expression constructs and methods of inducing gene expression using a combination of inducing agents.
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7056741 |
Surface transfection and expression procedure
The present invention relates to a method of transfecting cells comprising applying cells directly onto nucleic acids which are immobilized in transfection complexes on a surface and which...
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7049144 |
Process of making a compound by forming a polymer from a template drug
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for...
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7045356 |
Process for generating multilayered particles
We describe a process for generating multilayer particles comprising condensing a polymer with an oppositely charged polymer to form a particle and sequentially adding oppositely charged polymers...
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7037520 |
Reversible masking of liposomal complexes for targeted delivery
The present invention is a composition and process for avoiding non-specific uptake of targeted liposomal complexes in the lung and other highly vascular issues. The reversible masking of liposomal...
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7033607 |
pH-titratable polyampholytes for delivering polyions to a cell
A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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7029697 |
Controlled surface-associated delivery of genes and oligonucleotides
A system and methods for controlled gene delivery comprising condensed nucleic acids complexed with polylinkers, wherein the complexes are covalently and/or non-covalently bound to the surface of a...
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7025987 |
Delivery system for nucleic acids
α v β 3 Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic α v β...
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7022525 |
Process of making a compound by forming a polymer from a template drug
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for...
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7022336 |
Methods for attaching proteins to lipidic microparticles with high efficiency
The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a...
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7015040 |
Intravascular delivery of nucleic acid
Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the...
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7015019 |
1-O-L-arginyl ester 3-O-monoacyl glycerides and 1-O-L-arginyl ester 2,3-O-diacyl glycerides type surface active agents
This invention refers to new surface-active compounds derived from arginine of the mono and diacylglyceride type according to the general formula (I) designed to act as surface agents with...
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7008791 |
Liposome-entrapped DNA oral vaccines
An oral vaccine contain liposomes and complexed or, preferably entrapped, DNA operatively encoding an antigen in which the liposomes are formed from components including cationic compounds and...
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7005300 |
Polyhydroxy diamine surfactants and their use in gene transfer
The use of carbohydrate-based surfactant compounds having the general formula (I):
wherein Y 1 and Y 2 , which may be the same or different, are carbohydrate groups;
R 1 and R 2 , which may...
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6958241 |
Therapeutic liposome composition and method
A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological...
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6936729 |
Compound containing a labile disulfide bond
A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved...
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6919091 |
Compositions and methods for drug delivery using pH sensitive molecules
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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6905878 |
DNA array for high throughput solid-phase transfection and method for producing the same
The present invention relates to a DNA array for high throughput and highly efficient solid-based transfection which comprises a plurality of dried spots on a solid support, said dried spot...
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6902933 |
Surface transfection and expression procedure
The present invention relates to a method of transfecting cells comprising applying cells directly onto nucleic acids which are immobilized in transfection complexes on a surface and which...
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6897068 |
Polynucleotide complex delivery
Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not...
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6881576 |
Formation of polyampholytes in the presence of a polyion
A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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6881577 |
Method for improving transfection efficiency
The invention relates to a method for improving transfection efficiency through the use of K16-peptides. In addition, the invention further relates to novel K16-peptides, including a K16-CYC peptide.
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6875748 |
Compositions and methods for in vivo delivery of polynucleotide-based therapeutics
The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides...
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6875569 |
Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
In accordance with the present invention, it has been discovered that nuclear receptor proteins isolated from the silk moth bombyx mori (bR) are useful for the regulation of transgene expression....
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6875448 |
Method of intracellular sustained-release of drug and preparations
A substance of interest is contained in nanospheres which are then encapsulated in fusogenic liposomes to prepare transport carriers that allow physiologically active substances, especially those...
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6858226 |
Fusogenic lipids and vesicles
Novel lipid compounds are provided that may be termed “pro-cationic” in that they are neutral or negatively charged until they are either brought into contact with cellular membranes or are...
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6858224 |
Method of preventing aggregation of a lipid:nucleic acid complex
Particle aggregation of lipid:nucleic acid complex particles is prevented by incorporating a non-cationic lipid into lipid:nucleic acid complex particles containing a cationic lipid and a nucleic...
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6852334 |
Cationic peg-lipids and methods of use
The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth...
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6852709 |
Biologically useful polyphosphates
The present invention provides biodegradable polymers, polymer compositions, particles composed thereof and methods of using same for the controlled release of a biologically active substance to a...
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6835395 |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
Lipidic compositions with superior characteristics for in vivo delivery of oligodeoxynucleotides (ODN) can easily and efficiently be made in the form of small multilamellar vesicles. The...
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6828151 |
Antisense modulation of hematopoietic cell protein tyrosine kinase expression
Antisense compounds, compositions and methods are provided for modulating the expression of hematopoietic cell protein tyrosine kinase. The compositions comprise antisense compounds, particularly...
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6821956 |
Therapeutic use of cis-element decoys in vivo
The invention provides for the use of oligodeoxynucleotide decoys for the prophylactic or therapeutic treatment of diseases associated with the binding of endogenous transcription factors to genes...
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6812218 |
Lipid derivatives of polythiourea
The present invention relates to novel compounds which make it possible to transfer nucleic acids into cells. These novel compounds are lipid derivatives of polythiourea. They are useful for the in...
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6806084 |
Methods for compositions for in vivo gene delivery
Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be...
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6803360 |
Compositions and methods for reducing radiation and drug resistance in cells
Provided are antisense oligonucleotides directed against the raf-1 gene, Ha-ras gene and HER-2 gene, components of a signal transduction pathway involving oncogenes and their normal counterparts...
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6790442 |
Genomic DNA encoding a polypeptide capable of inducing the production of interferon-&ggr
Disclosed is a genomic DNA encoding a polypeptide capable of inducing the production of interferon-γ by immunocompetent cells. The genomic DNA efficiently expresses the polypeptide with high...
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6780641 |
Immortalized human microglia cell line
An immortalized human cell line is provided which has the characteristics of human embryonic microglia. Such immortalized microglia cells express CD68, CD11c and MHC class I and II antigens as...
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