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7585498 |
Regulation of adenovirus DNA packaging by IPTG
The present invention relates to recombinant Adenoviruses (Ad) which function as helper viruses to gutted Ad viruses lacking viral coding sequences. The recombinant Ad of the present invention...
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7524327 |
Light activated gene transduction using long wavelength ultraviolet light for cell targeted gene delivery
In accordance with the present invention, methods are provided for treating a patient through the use of ultraviolet light activated gene therapy. Embodiments of the present invention include...
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7494813 |
VAC-BAC shuttle vector system
The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome.
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7271002 |
Production of adeno-associated virus in insect cells
A method of producing an adeno-associated virus (AAV) in an insect cell comprising (i) providing at least one insect cell-compatible vector comprising a first nucleotide sequence comprising at...
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7195916 |
Method for expression of small antiviral RNA molecules within a cell
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded...
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7148341 |
AAV DNA comprising helper virus sequences
The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both.
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7132277 |
Helper dependent vector system for gene therapy
The present invention features helper-dependent adenoviral vector elements, and helper adenoviral elements, that enhance the production and isolation of helper-dependent adenoviral vectors. Such...
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7125717 |
Metabolically activated recombinant viral vectors and methods for their preparation and use
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
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7125549 |
Methods and compositions for efficient gene transfer using transcomplementary vectors
The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a...
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7094604 |
Production of pseudotyped recombinant AAV virions
Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped...
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7078218 |
Alphavirus particles and methods for preparation
Provided herein are methods for producing alphavirus replicon particles in high yield; replicon RNAs are electroporated into permissive cells, where the cells are at a relatively high density,...
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7078030 |
Oncolytic adenovirus
Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters...
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7070998 |
Adeno-associated virus materials and methods
The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV)...
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7056502 |
Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
A pseudotyped rAAV is described, which contains sequences derived from AAV5. A method for producing rAAV pseudotyped with AAV5 capsid is described in which the rep proteins of the serotype or any...
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7052881 |
Packaging systems for human recombinant adenovirus to be used in gene therapy
Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with...
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7052692 |
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells...
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7037723 |
Recombinant herpes viruses for preparing recombinant adeno-associated viruses
The invention relates to a recombinant herpes virus which contains the rep and cap genes of the adeno-associated virus, and to a method for producing high-titer, highly infectious adeno-associated...
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6995010 |
Gene transfer method
A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a...
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6979568 |
Vector for the expression of two foreign genes
A vector expressing two foreign genes by using RRE sequence and controlling the ratio of the expression doses of these genes owing to the modification is provided. This vector, which can be...
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6955919 |
Lentiviral packaging cells and uses therefor
Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing...
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6946126 |
Replicating adenovirus vectors
The present invention provides replicating [100K−] adenovirus vectors that have an impairment in 100K activity. In particular preferred embodiments, the impairment is the result of a deletion in...
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6943015 |
Large scale production of packaged alphavirus replicons
Large-scale packaging of alphavirus replicons is accomplished by co-transfecting host cells with three RNA molecules: (1) an alphavirus replicon comprising a sequence encoding a heterologous...
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6943012 |
Helper dependent adenoviral vector system and methods for using the same
A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human...
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6936466 |
Transcriptionally-activated AAV inverted terminal repeats (ITRs) for use with recombinant AAV vectors
This invention provides transcriptionally-activated AAV ITRs (inverted terminal repeats) which are small and transcriptionally active and uses thereof to optimize the expression of relatively large...
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6924128 |
Packaging cell lines for generation of high titers of recombinant AAV vectors
AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be...
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6899870 |
Induction of apoptic or cytotoxic gene expression by adenoviral mediated gene codelivery
The present invention generally relates to viral vectors and their use as expression vectors for transforming human cells, both in vitro and in vivo. More particularly, the present invention...
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6897045 |
Adeno-associated virus vectors
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
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6875610 |
Methods and compositions for efficient gene transfer using transcomplementary vectors
The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a...
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6872561 |
Immortalized avian cell lines
The invention features non-transformant immortal avian cells, in particular derived from avian tissues, i.e., other than blood or hematopoietic cells, particularly fibroblasts and epithelial cells,...
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6867022 |
Replication deficient adenovirus vectors and methods of making and using them
The invention provides novel replication deficient adenovirus vectors and methods for making and using these viruses. The invention also provides vector systems and kits using a serotype specific...
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6844192 |
Adenovirus E4 protein variants for virus production
A method of packaging a recombinant viral vector is carried out by: (a) providing a packaging cell, the packaging cell containing and expressing a nucleic acid encoding a mutant adenovirus E4orf6...
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6830892 |
Lentiviral vector system for high quantity screening
A method of screening for a target molecule from a group of potential target molecules is described. This method involves using a library of lentiviral vectors where the members encode the group of...
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6821776 |
Reconstituting retroviral vector (recon vector) for targeted gene expression
The present invention relates to a retroviral vector which is especially applicable as a safe gene transfer vehicle for targeted gene therapy. Said retroviral vector comprises one or more promoters...
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6821512 |
Compositions and methods for increasing packaging and yield of recombinant adenoviruses using multiple packaging signals
A recombinant adenoviral vector which has multiple adenovirus packaging domains is provided. This vector has advantages over conventional adenoviral vectors in packaging plasmid vectors into...
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6818209 |
Retroviral delivery system
A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope...
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6808923 |
Episomally replicating lentiviral vectors
The invention is directed to a lentiviral vector system that can be used for episomal replication of a desired gene. The vector system contains a first vector containing a lentiviral gag gene...
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6806080 |
Hybrid vectors for gene therapy
The invention discloses hybrid vectors for delivering genes or other nucleic acids into mammalian cells. The hybrid vectors of the invention contain both a helper dependent adenoviral portion and a...
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6800442 |
Methods of selecting polynucleotides encoding antigens
The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of...
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6793926 |
Methods for production of a recombinant adeno-associated virus
This invention relates to novel nonmammalian carrier vectors and viruses useful in the production of high titers of recombinant viruses which may contain foreign DNA inserts or which may be...
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6753419 |
DNA molecules encoding hormone-dependent forms of the adeno-associated virus rep proteins
The subject matters of this invention are the hormone-dependent forms of Rep 78 and Rep 68 proteins of the Adeno-associated virus (AAV), obtained by the fusion of their specific mutants with the...
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6743631 |
Use of human serum resistant vector particles and cell lines for human gene therapy
The present invention relates to the use of non-primate mammalian cell lines having substantially no endogenous retroviral sequences as producer and packaging lines for preparation of human...
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6743620 |
Method for preparing retrovirus vector for gene therapy
The present invention provides a process for preparing a retrovirus to be expressed at a high titer by specifically transferring a desired foreign gene into target cells. A pseudotyped retrovirus...
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6740525 |
Adenoviral capsid containing chimeric protein IX
The present invention provides a chimeric protein IX (pIX). The chimeric pIX protein has an adenoviral pIX domain and also a non-native amino acid. Where the non-native amino acid is a ligand that...
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6706477 |
Methods for producing polynucleotide libraries in vaccinia virus
The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of...
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6699690 |
Molecular constructs with a carcinoembryonic antigen (CEA) transcriptional regulatory sequence
Novel molecular chimaeras produced by recombinant DNA techniques are described. They comprise a target-tissue specific transcriptional regulatory sequence (TRS) linked and controlling the...
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6692750 |
Alphavirus expression vector
The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having...
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6692736 |
Cell-specific adenovirus vectors comprising an internal ribosome entry site
Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional...
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6686200 |
Methods and compositions for the large scale production of recombinant adeno-associated virus
This invention provides novel methods and compositions for use in the efficient and large-scale production of recombinant adeno-associated virus (AAV). Described herein are new producer cell lines,...
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6677155 |
Triple hybrid amplicon vector systems to generate retroviral packaging lines
The present invention relates to a triple hybrid vector amplicon system comprising genetic elements derived from Herpes Simplex Virus (HSV), Epstein-Barr Virus (EBV) or Adeno-Associated Virus...
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6670176 |
Adeno-associated virus capable of expressing factor IX protein and cells comprising the same
The subject invention concerns a recombinant adeno-associated virus vector characterized as being capable of delivering and expressing at least one mammalian gene into a genome of a mammalian host...
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