|
Match
|
Document |
Document Title |
|
|
7618623 |
Hybrid adeno-retroviral vector for the transfection of cells
An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid...
|
|
|
7612042 |
Methods for inhibiting heregulin and treating cancer
The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention...
|
|
|
7608255 |
Replication-competent anti-cancer vectors
Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to...
|
|
|
7598078 |
Settings for recombinant adenoviral-based vaccines
The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy....
|
|
|
7592169 |
Methods and compositions for treatment and prevention of HSV-2 infections and conditions
Live, attenuated, phenotypically stable HSV-2 viruses and methods of making and using the virus are provided. Live, attenuated HSV-2 viruses are constructed using recombinant techniques and can be...
|
|
|
7592149 |
Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer
A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
|
|
|
7585498 |
Regulation of adenovirus DNA packaging by IPTG
The present invention relates to recombinant Adenoviruses (Ad) which function as helper viruses to gutted Ad viruses lacking viral coding sequences. The recombinant Ad of the present invention...
|
|
|
7575924 |
Methods and compositions relating to improved lentiviral vectors and their applications
The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic...
|
|
|
7572455 |
Vaccine comprising an attenuated pestivirus
Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein E rns and at least another mutation in the coding sequence for N...
|
|
|
7569217 |
Porcine adenovirus E1 and E4 regions
The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the...
|
|
|
7560527 |
Modified adenovirus fibre and uses
The invention concerns an adenovirus fiber modified by mutation of one or several residues of the region included between residues 491 and 505 of SEQ ID NO: 1, the viral particles or...
|
|
|
7541181 |
Vector carrying a polynucleotide which encodes a GSD polypeptide from Mycobacterium paratuberculosis
The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open...
|
|
|
7521239 |
Photochemical internalization for virus-mediated molecule delivery into the cyosol
A method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosensitizing agent, the cell is irradiated with light of a wavelength effective to activate...
|
|
|
7517670 |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins...
|
|
|
7507752 |
Biosynthetic gene cluster for the production of a complex polyketide
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided...
|
|
|
7494813 |
VAC-BAC shuttle vector system
The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome.
|
|
|
7491525 |
Specific proliferation in tumour cell which can express antioncogene with high efficiency and the use of it
The present invention provides a recombinant virus, which highly expresses a cancer therapeutic gene and specifically proliferates in tumor cells, and a method for the proliferation of the same. In...
|
|
|
7481998 |
Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the...
|
|
|
7470426 |
Treatment of neoplasms with viruses
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic...
|
|
|
7465583 |
Duplexed parvovirus vectors
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
|
|
|
7459154 |
Methods and reagents for the enhancement of virus transduction in the bladder epithelium
Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition...
|
|
|
7439066 |
Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV)
The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to...
|
|
|
7439065 |
Helper virus-free AAV production
A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method...
|
|
|
7419829 |
Vector system
The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can...
|
|
|
7416890 |
Baculovirus vector, method of producing thereof and method of gene transfer
The present invention provides a novel baculovirus vector which can provide a desired protein not requiring infectivity to insect cells, on the viral particle surface; method of producing thereof;...
|
|
|
7407807 |
Chimaeric human papillomavirus 16 I1 virus like particles and a method for preparing the particles
The invention describes a method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide. The method comprises the...
|
|
|
7407801 |
Truncated CMV promoters and vectors containing same
The present invention relates to nucleic acid molecules comprising certain truncated forms of the human cytomegalovirus (CMV) immediate-early enhancer-promoter, either alone or operably linked to...
|
|
|
7405038 |
Stable cell lines resistant to apoptosis and nutrient stress and methods of making same
Cell lines that are commonly used for protein expression are engineered to include genes that encode suppressors of apoptosis (SA). Insect cell lines expressing these SA genes are resistant to...
|
|
|
7393677 |
Avidin-pseudotyped viral vectors and their use
The present invention pertains to an avidin-pseudotyped virus, and especially baculovirus, useful for delivery of foreign genes etc. The present invention also pertains to vectors comprising...
|
|
|
7361496 |
Rescue of mumps virus from cDNA
This invention relates to a method for recombinantly producing, via rescue of mumps virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom....
|
|
|
7351877 |
Lambda integrase mediated recombination in plants
The present disclosure provides methods for obtaining the targeted integration of a DNA molecule into the genome of a host cell using a recombinase. The methods disclosed herein can be used with a...
|
|
|
7351697 |
Tumor-specific vector for gene therapy
The invention relates to a vector for the gene therapeutic treatment of tumors, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence...
|
|
|
7348178 |
Recombinant adenoviral vector system
The present invention relates to a novel Ad based packaging system that can be used for incorporation of heterologous DNA into infectious but replication defective viral particles. The components...
|
|
|
7332338 |
Vectors for making genomic modifications
Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the...
|
|
|
7332322 |
Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof
The present invention provides a Venezuelan equine encephalitis virus replicon RNA useful in the development of stable lines of mammalian, avian and insect cells in which these replicons will...
|
|
|
7323619 |
Method for producing transgenic birds and fish
The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest.
|
|
|
7323337 |
Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors
Highly efficient gene transfer into primate-derived embryonic stem (ES) cells has successfully been achieved by using a simian immunodeficiency virus vector (SIV) pseudotyped with VSV-G protein,...
|
|
|
7323177 |
Recombinant porcine adenovirus vector
This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The...
|
|
|
7319036 |
Method for generating hypermutable organisms
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and...
|
|
|
7319033 |
Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and...
|
|
|
7318919 |
Adenovirus vectors for gene therapy
Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
|
|
|
7311907 |
Lentiviral packaging cells
Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing...
|
|
|
7306794 |
Methods and compositions for the treatment of defects in lipoprotein metabolism
The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic...
|
|
|
7306792 |
Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors
The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to Sindbis virus vectors...
|
|
|
7297542 |
Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention...
|
|
|
7294761 |
Method for efficiently producing transgenic plant using auxin precursor
A method for producing a transgenic plant, which comprises: (A) introducing a vector into a plant cell, wherein the vector is a vector for gene introduction into a plant and comprises: a desired...
|
|
|
7294500 |
Mosaic infectious bursal disease virus vaccines
The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable...
|
|
|
7291498 |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing...
|
|
|
7285542 |
Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene...
|
|
|
7285265 |
Stable adenoviral vectors and methods for propagation thereof
The present invention provides methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by...
|