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7615374 |
Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions
Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
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7612046 |
Method for treating kidney disorders
The present invention relates to a cellular therapy of renal failure, i.e. preventing, delaying, and treating acute/chronic renal failure via the use of an effective dose of a substance capable of...
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7611851 |
Canis sphingosine 1-phosphate receptor isoform 1
A Canis sphingosine-1-phosphate (S1P) receptor isoform 1 (cS1P 1 ), the nucleic acid encoding the cS1P 1 receptor, and methods for using the cS1P 1 receptor and the nucleic acid encoding the...
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7608431 |
Fed-batch process for production of erythropoietin in human embryonic retina cells that express adenovirus E1A
The invention provides processes for recombinant production of erythropoietin (EPO) in a human embryonic retina cell that expresses at least an adenoviral E1A protein, wherein said EPO is produced...
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7608425 |
Methods for protein expression in mammalian cells in serum-free medium
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies,...
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7608422 |
Simian immunodeficiency virus (SIV) molecular clone encoding mutant gag gene lacking inhibitory/instability regions
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host...
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7604995 |
Compositions, kits, and methods for stimulation of homologous recombination
A method of stimulating homologous recombination by creating at least one nick in a targeted polynucleotide sequence. Wherein nonhomologous recombination is suppressed resulting in increasing the...
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7604994 |
Genetically altered antibody-producing cell lines with improved antibody characteristics
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. Cells may be selected for expression of activation-induced cytidine deaminase...
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7604960 |
Transient protein expression methods
Described is a method for producing a protein of interest, the method comprising: a) providing a recombinant adenoviral vector comprising nucleic acid encoding the protein of interest under control...
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7604803 |
Method to enhance an immune response of nucleic acid vaccination
A composition for the co-delivery to a cell of a nucleic acid and an assistor protein, comprising vesicles, nucleic acid and protein, wherein the nucleic acid operatively encodes an antigenic...
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7601687 |
Mechanism for identifying drugs for the treatment of type II diabetes
Insulin resistance is a central feature of type II diabetes and other diseases, and may affect every tissue of the body, including the pancreatic beta cell. Insulin signaling is mediated by a...
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7601345 |
Lentivirus vectors for gene transfer to alveolar epithelial cells
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical...
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7598078 |
Settings for recombinant adenoviral-based vaccines
The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy....
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7598077 |
Compositions and methods for enhancing differential expression
Artificial TERT promoters, which are useful for enhancing the differential expression of operably linked heterologous nucleic acid sequences, such as polypeptide cytotoxins, are disclosed herein....
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RE40930 |
Porcine adenovirus type 3 genome
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
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7595193 |
Propagation and/or derivation of embryonic stem cells
Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered....
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7595187 |
Elaiophylin biosynthetic gene cluster
The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of streptomycete that is responsible for elaiophylin biosynthesis and that...
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7592504 |
Methods for determining specificity of RNA silencing and for genetic analysis of the silenced gene or protein
Methods and kits for determining the specificity of siRNAs for their targets are provided. Also provided is a method for performing genetic analysis of the target protein or gene using different...
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7592502 |
Knock-in non-human animal producing human tissue factor
A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been...
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7592319 |
Uses of DNA-PK
This invention provides a method for increasing the susceptibility of a cell to DNA-damaging agents, comprising introducing into the cell an antisense oligonucleotide that specifically hybridizes...
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7592317 |
Constitutive gene expression in conjuction with ionizing radiation
The present disclosure demonstrates the successful use of constitutive promoters operatively linked to genes encoding radiosensitizing or radioprotecting factors, administered to cells, tissues, or...
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7592174 |
Isolation of mesenchymal stem cells
Methods and compositions are provided for the identification and isolation of mammalian mesenchymal stem cells. The methods of the invention provide a means to obtain substantially homogeneous MSC...
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7589258 |
Plant farnesyltransferases
This invention relates to an isolated nucleic acid fragment encoding a farnesyltransferase subunit. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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7588915 |
Isolated genomic polynucleotide fragments from chromosome 7
The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD...
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7585960 |
Nucleic acids encoding superagonistic anti-CD28 antibodies
The present invention relates to one or more nucleic acid(s) encoding a binding molecule specifically binding to a human CD28 molecule, comprising
(a) a nucleic acid sequence encoding a VH...
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7585676 |
Retroviral vector
Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.
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7585675 |
Inhibition of HIV and SHIV replication with antisense interleukin-4
A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication...
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7585666 |
Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
A novel nucleic acid construct for down-regulating angiogenesis in a tissue of a subject is provided. The nucleic acid construct includes: (a) a first polynucleotide region encoding a chimeric...
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7585636 |
Protein subcellular localization assays using split fluorescent proteins
The invention provides protein subcellular localization assays using split fluorescent protein systems. The assays are conducted in living cells, do not require fixation and washing steps inherent...
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7585623 |
Adiponectin promoter and use thereof
The present invention relates to a DNA having a promoter region containing regulatory sequences of human adiponectin gene, transformants transformed with the DNA, a screening method of a compound...
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7585622 |
Increasing the proliferative capacity of cells using telomerase reverse transcriptase
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7585498 |
Regulation of adenovirus DNA packaging by IPTG
The present invention relates to recombinant Adenoviruses (Ad) which function as helper viruses to gutted Ad viruses lacking viral coding sequences. The recombinant Ad of the present invention...
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7582741 |
Conditional disruption of dicer1 in cell lines and non-human mammals
The present invention is based, at least in part, on the generation of cells, cell lines and non-human mammals that contain a synthetic conditional allele of the Dicer1 gene. Many of the...
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7582613 |
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
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7582475 |
Vectors and methods for high throughput co-expression
The present invention includes vectors and methods for high throughput co-expression.
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7579330 |
Methods of treating various cancers using melanoma differentiation associated protein-7
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
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7575896 |
Cell fusion method
The invention provides methods for fusing a first cell with a second cell to form a hybrid cell. The methods involve incubating a first parental cell producing a first partner of a fusogenic...
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7575752 |
Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning...
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7572633 |
Use of the adenoviral E2 late promoter
The invention relates to a nucleic acid construct comprising an adenoviral E2 late promoter or a fragment thereof and a nucleic acid. The nucleic acid is selected from the group of transgenes,...
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7572438 |
Mutant having uracil phosphoribosyl transferase activity
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence...
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7569385 |
Multipotent amniotic fetal stem cells
A source of multipotent amniotic fluid/fetal stem cells (MAFSCs) is disclosed. MAFSC are of fetal origin and have a normal diploid karyotype. These cells are characterized by the following cell...
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7569362 |
Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing
The invention provides a method of producing multiple polypeptides, such as antibodies or antibody fragments, in a eukaryotic cell using a single expression vector. The expression vector is...
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7569220 |
Compositions and methods for non-targeted activation of endogenous genes
The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods...
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7569217 |
Porcine adenovirus E1 and E4 regions
The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the...
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7563881 |
Nucleic acid encoding polypeptide involved in cellular entrance of the PRRS virus
The present invention relates to a new polynucleotide that encodes a polypeptide involved in cellular entrance of PRRSV, to a recombinant vector comprising said polynucleotide, to a cell capable of...
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7563778 |
Antisense oligonucleotide preparation method
A method for the preparation of an antisense oligonucleotide or derivative thereof comprising the steps of: selecting a target nucleic acid, if necessary elucidating its sequence; generating the...
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7563777 |
Method to induce neovascular formation and tissue regeneration
The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle...
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7563619 |
Mammary stem cell marker
It is disclosed here that low density lipoprotein receptor-related protein 5 (LRP5) is a cell surface marker for somatic mammary stem cells and mammary tumor stem cells. The disclosure here...
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7560540 |
Nucleic acid encoding dendritic cell co-stimulatory molecules
A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments,...
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7560538 |
Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region
The present invention provides porcine isogloboside 3 (iGb3) synthase protein, cDNA, and genomic DNA regulatory sequence. The present also invention includes porcine animals, tissue and organs as...
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