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7264949 |
Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
The promoter region associated with the Yarrowia lipolytica glycerol-3-phosphate O-acyltransferase (gpat) gene has been found to be particularly effective for the expression of heterologous genes...
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7256018 |
Microorganism producing L-threonine having inactivated tyrR gene, method of producing the same and method of producing L-threonine using the microorganism
Provided are a microorganism capable of producing L-threonine and having an inactivated tyrR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The...
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7229794 |
Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism
Provided are a microorganism capable of producing L-threonine and having an inactivated galR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The...
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7223567 |
Mutant E. coli strain with increased succinic acid production
The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic...
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7153676 |
Transacylases of the paclitaxel biosynthetic pathway
Transacylase enzymes and the use of such enzymes to produce paclitaxel, related taxoids, as well as intermediates in the paclitaxel biosynthetic pathway are disclosed. Also disclosed are nucleic...
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6518039 |
Process for the fermentative production of deacylated cephalosporins
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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6503727 |
Process for the preparation of an antibiotic
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a...
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6455284 |
Metabolically engineered E. coli for enhanced production of oxaloacetate-derived biochemicals
Metabolic engineering is used to increase the carbon flow toward oxaloacetate to enhance production of bulk biochemicals, such as lysine and succinate, in bacterial fermentations. Carbon flow is...
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6403356 |
Mutant penicillin G acylases
New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said...
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6218138 |
Synthesis of beta-lactam antibiotics with immobilized penicillin amidase
Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase...
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6060268 |
Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer
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6048708 |
Process for preparation of β-lactams at constantly high concentration of reactants
An improvement for enzymatically syhnthesizing a β-lactam compound is presented. The improvement comprises catalyzing the acylation of an amino β-lactam with an acylating agent for at least 5 h...
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6033823 |
Mutated penicillin G acylase genes
New mutant β-lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding said Penicillin G ...
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5916762 |
Process for the recovery of ampicillin
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from...
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5780260 |
Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier
An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an...
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5753458 |
Acylation method for penicillins and cephalosporins
A method for providing a semisynthetic β-lactam antibiotic by enzyme catalyzed acylation of the parent β-lactam with an activated derivative of the side chain acid wherein a modulator, which c...
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5525483 |
Process for preparation of β-lactams utilizing a combined concentration of acylating agent plus β-lactam derivative of at least 400 mm
β-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino β-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration o...
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5268271 |
Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase
Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a ...
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5215891 |
Process for preparing penems
A process for preparing a compound of formula I: ##STR1## wherein R1 represents a hydroxy protecting group and R2 represents a carboxy protecting group, which comprises: hydrolyzing a compound of...
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5079146 |
Method of protection of the carboxy groups in the chemistry of β-lactam compounds
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by ...
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4945159 |
Formation of lactams and other amides under mild conditions by action of cyanogen
A method for the formation of intramolecular amide bonds by the action of cyanogen, under mild reaction conditions, in the preparation of cyclic amides, including lactams, in biologically active...
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4621048 |
Reagents containing an anti-ligand bound to an anti-enzyme and methods for employing said reagents in an immunoassy
The invention relates to a method and novel reagents for detecting a ligand in a biological sample. In the method, the sample is combined with (i) an enzyme or an enzyme bound to a first...
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4340672 |
Enzymatic synthesis of β-lactam antibacterials
Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl...
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4250258 |
Use of phenoxyalkanes as precursors in penicillin V fermentation
Penicillin V is prepared by culturing a penicillin-producing microorganism in a medium containing suitable sources of nitrogen, carbon and energy, and inorganic salts. One or more phenoxyalkanes of...
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4167446 |
Water soluble carrier-bound penicillinacylase
A water-soluble non-colloidal penicillinacylase preparation containing penicillinacylase covalently bound to a water-soluble carrier is produced by reacting penicillinacylase with an activated...
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4073687 |
Enzymatic acylation to afford β-lactam antibiotics
Penicillin or cephalosporin antibiotics represented by following formula: ##STR1## where ##STR2## is an acyl group derived from an α-amino acid, N-ammonium salt of α-amino acid, or N--(C1 to C10) a...
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4053360 |
Enzymatic preparation of 6-D-(-)-α-amino-α-(p-hydroxyphenylacetamino)penicillin acid
This invention relates to a novel α-aminoα-(p-acyloxyphenyl)acetamidopenicillanic acid which is useful as an antibacterial agent, and also to a novel process for the production of 6...
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3925155 |
Preparation of 6-aminopenicillanic acid 1-oxide
6-Aminopenicillanic acid 1-oxide or its salt is prepared by the action of a microorganism belonging to the genus Streptomyces or its mycelium preparation on a penicillin 1-oxide or its salt.
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3787288 |
METHOD FOR PREPARING ALPHA-AMINOBENZYLPENICILLIN
A process for the selective production of α-amino-benzylpenicillin from 6-aminopenicillanic acid, functional derivatives thereof and acid addition salts thereof whereby the reaction takes place in ...
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3717548 |
METHOD FOR PREPARING AMINOCYCLOHEXYLPENICILLIN
An enzymatic process for the preparation of aminocyclohexylpenicillin is disclosed. The process involves reacting together 6-aminopenicillanic acid or other penicillins and aminocyclohexyl...
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3716454 |
PROCESS FOR THE PRODUCTION OF α-AMINOBENZLPENICILLIN
A process for the enzymatic production of D-(-)-α-aminobenzylpenicillin, i.e., Ampicillin, which is one of the semi-synthetic penicillins useful as an antibiotic, starting from 6-aminopenicillanic ...
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3682777 |
PROCESS FOR PRODUCING PENICILLIN DERIVATIVES
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3749642 |
METHOD FOR THE PRODUCTION OF AMINOPENICILLINS
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3152050 |
Enzymatic process for preparing penicillins
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3079306 |
Process for the production of 6-acylaminopenicillanic acids
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3079307 |
Process for the enzymatic acylation of 6-aminopenicillanic acid
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