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8183011 |
RNA interferases and methods of use thereof
The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present...
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8183433 |
Method of controlling gene expression in plants or plant cells
A method of controlling a genetically-modified plant or plant cells, said method comprising the following steps: (a) providing a genetically-modified plant or plant cells, said plant or plant cells...
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8173402 |
Modified yeasts and uses thereof, in particular for producing steroid derivatives
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More...
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8173790 |
Insect desiccation resistance genes and uses thereof
An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof cDNA libraries were produced from Polypedilum vanderplanki...
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8163532 |
Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase
The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
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8158413 |
Lentiviral vector-based vaccine
Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile...
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8158404 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8153415 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8153391 |
Hydrolases, nucleic acids encoding them and methods for making and using them
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
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8153431 |
Compositions and methods for making mutations in cell lines and animals
The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for...
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8148100 |
Mina53 assays
The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53.
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8148117 |
Microorganism and process for the preparation of L-methionine
The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and...
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8137950 |
Bacteriophage resistant lactic acid bacteria
A lactic acid bacterium (LAB) wherein an YjaE protein is essentially inactive and the LAB thereby get improved resistance to bacteriophages, a starter culture composition comprising the lactic acid...
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8137940 |
Method for production of biomass using a gluconobacter oxydans comprising an inactivated NADP dependent glucose dehydrogenase gene
The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as e.g. glucose. Processes for generating...
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8137925 |
Methods and compositions for protein labeling using lipoic acid ligases
The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and...
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8138324 |
Expression system for proteins
The invention provides a novel system for the tunable expression of nucleic acids encoding e.g., polypeptides such as recombinant proteins in prokaryotic systems. The system is based on the ability...
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8133711 |
BGL7 beta-glucosidase and nucleic acids encoding the same
The present invention provides BGL7 polypeptides with the biological activity of a β-glucosidase and a method of producing a recombinant enzyme having β-glucosidase activity.
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8133715 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8133710 |
Oligoadenylate synthetase (OAS)
The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have...
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8133714 |
Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form
The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR...
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8129162 |
Ketol-acid reductoisomerase using NADH
Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from...
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8124411 |
Methods for producing transgenic plants
A method of producing a stably transformed corn plant in a single container is demonstrated. This method allows for the automation of the transformation process and reduces labor, material, and...
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8119603 |
Modified human interferon polypeptides and their uses
Modified human interferon polypeptides and uses thereof are provided.
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8119383 |
Glycosidase enzymes
A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can...
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8114655 |
EGVII endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host...
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8114650 |
Nucleic acid and its use effecting ciliate tetrahymena bifunctional dihydrofolate reductase-thymidylate synthase deficiency
A method for producing a ciliate cell with reduced or essentially no dihydrofolate reductase (DHFS) activity or reduced or essentially no thymidylate synthase (TS) activity or both reduced or...
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8114651 |
Method for producing 4-hydroxy-L-isoleucine
A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an...
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8114629 |
Site specific incorporation of keto amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases,...
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8110388 |
Lysophosphatidic acid acyltransferase genes
The present invention provides novel lysophosphatidic acid acyltransferase genes. A nucleic acid comprising the nucleotide sequence shown in SEQ ID NO: 1, 3, 36 or 37 or a fragment thereof.
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8105799 |
Methods of screening compounds inhibiting signal transduction through inflammatory cytokines
Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other...
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8097702 |
Modified human interferon polypeptides with at least one non-naturally encoded amino acid and their uses
Modified interferon polypeptides with at least one non-naturally-encoded amino acid and uses thereof are provided.
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8097443 |
Nucleotidyltransferases with enhanced nucleotide triphosphate flexibility
The present invention provides mutant RmlA enzymes possessing an increased purine/pyrimidine bias in nucleotide triphosphate substrate specificity as compared to a corresponding non-mutated RmlA...
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8097459 |
Methods and compositions for increasing replication capacity of an influenza virus
In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza...
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8093356 |
Pegylated human interferon polypeptides
Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
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8092988 |
Medium and method of deriving and using a mutated bacteria strain
A new strain of Bacillus anthracis derived from the Sterne vaccine strain of Bacillus anthracis by growth on a high-nitrate-concentration, 3-amino-L-tyrosine growth medium.
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8093042 |
Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA
The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1...
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8088906 |
FAD4, FAD5, FAD5-2, and FAD6, novel fatty acid desaturase family members and uses thereof
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase...
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8088613 |
Nitrilases, nucleic acids encoding them and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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8088620 |
Optimised micro-organism strains for NADPH-consuming biosynthetic pathways
The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in...
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8084041 |
Use of mycrobacterial vaccines in CD4+ or CD8+ lymphocyte-deficient mammals
Methods of treating a mammal that is deficient in CD4+ and/or CD8+ lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis...
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8080640 |
Recombinant transferrins, transferrin half-molecules and mutants thereof
Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant...
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8076138 |
Evolution of whole cells and organisms by recursive sequence recombination
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of...
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8076114 |
Cytochrome P450 oxygenases
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent...
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8076109 |
Processes for producing a fermentation product
The present invention relates to processes for producing a fermentation product, such as ethanol, from milled starch-containing material comprising (a) saccharifying the milled starch-containing...
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8071351 |
Family 44 xyloglucanases
The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the...
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8071347 |
Ketoreductases and uses thereof
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
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8067221 |
Von Willebrand factor (vWF)-cleaving protease
This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a...
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8058001 |
Oligonucleotide mediated nucleic acid recombination
Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase...
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8058506 |
Site-targeted transformation using amplification vectors
A process of causing a targeted integration of DNA of interest into a plant cell nuclear genome, comprising; i) providing plant cells with an amplification vector, or a precursor thereof, capable...
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8058505 |
Cybrid plant of the genus Lactuca and method for producing the same
A cytoplasmic male sterile cybrid plant of the genus Lactuca, a progeny thereof, or a part thereof having a gene derived from the mitochondria of a plant of the genus Helianthus in its cytoplasm...
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