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6709866 |
Methods for enhancing survival of a neuron
NAIP and IAP polypeptides prevent neuronal cell death caused by ischemia, neurodegenerative conditions, and axotomy. The invention provides methods for neuroprotection by the prevention of cell...
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6706503 |
Directed evolution of microorganisms
The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses...
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6706524 |
Method of improving the primary energy metabolism of mammalian cell lines
The invention relates to a method of improving the primary energy metabolism of mammalian cell lines, in which by means of genetic engineering a structural gene for a cytoplasmic yeast pyruvate...
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6703240 |
Modified starch metabolism enzymes and encoding genes for improvement and optimization of plant phenotypes
The invention provides methods for generating, identifying, and selecting polynucleotides encoding novel starch metabolizing enzymes (NSME), NSME-encoding polynucleotides, compositions of...
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6699479 |
Recombinant newcastle disease virus as an embryo vaccine
The present invention provides a NDV mutant which is suited as vaccine candidate for in ovo vaccination. The mutant expresses reduced levels of V protein and can safely be administered to chicken...
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6696278 |
Method for transfer of DNA segments
The present invention provides a method of transfer of a gene of interest from a first vector to a product vector comprising contacting a first and second vector in vitro with a site-specific...
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6696293 |
Process for producing carotenoids and biological materials useful therefor
A process for producing carotenoids, which involves cultivating a microorganism obtained by treating a parent microorganism that produces carotenoids under conditions that induce a reduction in...
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6696294 |
Methods for generating and identifying mutant polyploid plants, and uses therefor
The present invention provides methods for generating and identifying mutations in any target gene of a polyploid plant species. In a preferred aspect of the present invention, a plant is...
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6692911 |
Cell delivery compositions
The present invention provides improved cell delivery compositions. In particular, the invention provides biocompatible endosomolytic agents. In a preferred embodiment, the endosomolytic agents are...
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6692942 |
Single-chain polypeptides for targeted delivery of nucleic acids
The present invention is directed to a method of in vivo and ex vivo gene delivery, for a variety of cells. More specifically, it relates to a novel carrier system and method for targeted delivery...
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6689578 |
Methods for the identification of inhibitors of 5-aminolevulinate synthase as antibiotics
The present inventors have discovered that 5-Aminolevulinate synthase is essential for fungal pathogenicity. Specifically, the inhibition of 5-Aminolevulinate synthase gene expression in fungi...
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6686515 |
Homologous recombination in plants
Methods for evolving recombinase protein homologues and RecA/VirE2 fusion proteins which complement VirE2 deficient Agrobacterium are provided. The use of recombinase protein homologues and...
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6683170 |
Ligands added to adenovirus fiber
The fiber protein of adenovirus has been genetically altered via attachment at the carboxyl end of a peptide linker, preferably up to 26 amino acids in length which forms a random coil, which can...
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6677432 |
Mutations of the C-terminal portion of TGF-β superfamily proteins
The invention provides modified proteins and DNAs of the TGF-β superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical...
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6673610 |
Method for mutagenesis
The present invention provides an entirely new method for mutagenesis, which is simple, speedy, economical, and widely-applicable. A method for mutagenesis comprising steps of: DNA synthesis in...
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6673580 |
Identification and modification of immunodominant epitopes in polypeptides
The invention provides for methods of modifying immunodominant epitopes on polypeptides, preferably polypeptides intended for therapeutic use. Knowledge of immunodominant epitopes prior to clinical...
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6673609 |
Recombinant human erythropoietin with advantageous glycosylation profile
A method for the production of a polypeptide, the method comprising culturing, under conditions which allow for the expression of DNA encoding SEQ ID NO:2 in an eukaryotic host cell, wherein the...
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6670329 |
Selenocosmia huwena toxin and analgesic uses thereof
Disclosed is a analgesic composition containing the purified HWAP-I polypeptide of the Chinese bird spider, Selenocosmia Huwena.
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6660274 |
Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
A novel isolated Borrielia burgdorferi sensu lato surface antigen is characterized by a relative molecular mass of 39.5 kDa. This antigen is expressed in vitro by spirochetes of a B. burgdorferi...
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6660492 |
Chimeric serine proteases
A chimeric serine protease whose protease domain is composed of two domain halves (half-sides) with a β-folded sheet structure, wherein the first domain half corresponds to the first domain half...
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6646181 |
Solid matrix control of seed conditioning using selected cell cycle stages
In the process of the invention, the seed to be treated, a predetermined amount of solid matrix material and a predetermined amount of water are admixed and the mixture allowed to stand, preferably...
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6635457 |
Selection for more efficient transformation host cells
This invention provides methods for producing and selecting host cells that better survive transformation treatment by subjecting host cells to conditions that alter them, subjecting the altered...
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6632636 |
Nucleic acids encoding 3-ketoacyl-ACP reductase from Moraxella catarrahalis
The present invention provides the genomic sequences of a library of purified nucleic acid molecules, or their complements, comprising the genome of Moraxella catarrhalis . The invention also...
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6630455 |
Methods for inducing mucosal immune responses
The invention provides a method of inducing a mucosal immune response in a subject, comprising administering to the mucosa of the subject an amount of antigen-encoding DNA effective to induce a...
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6627736 |
Pap mutants that exhibit anti-viral and/or anti-fungal activity in plants
Disclosed are PAP mutants having reduced phytotoxicity compared to wild-type PAP, and which confer broad spectrum resistance to viruses and/or fungi in plants. One group of PAP mutants is...
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6627423 |
21481, a novel dehydrogenase molecule and uses therefor
The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense...
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6623951 |
HBV vectors and cells for producing the same
This invention relates to an HBV vector in which functional genes of HBV are at least partially deleted. In addition, this invention concerns a process for producing such an HBV vector as well as...
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6620597 |
Method for in vitro amplification of circular DNA
A method for generating and amplifying closed circular DNA having a specific sequence in vitro in a cell-free system is disclosed. Prior to the invention of this method, closed circular DNA could...
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6617153 |
Portable magneto-mechanical delivery device and method for delivery of reactive substances
A method of delivery of reactive substances that are attached to magnetizable needle-like particles using a magneto-mechanical delivery device. The subject method and device can be utilized for the...
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6617163 |
Polynucleotides for mutagenesis in fungus comprising a functional gene in magnaporthe and an impala transposon
The invention concerns a new tool for efficient mutagenesis enabling the generation of a collection of mutants in fungi by random insertion of a characterized Fusarium oxysporum Impala transposon...
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6613554 |
Isolated human enzyme, nucleic acid molecules encoding human enzyme, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically...
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6613569 |
Inducible packaging cell lines for lentivirus vectors
Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of...
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6610479 |
Activating a reversibly inactivated immobilized enzyme by release from an immobilizing moiety
Enzymes or catalytic fragments thereof reversibly inactivated by attachment to an immobilizing moiety which may comprise a magnetic particle are activated by release from the immobilizing moiety....
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6610289 |
Mutated herpes simplex virus type 1 thymidine kinases and uses thereof
The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided...
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6602712 |
Enterotoxin-deficient bacillus
A enterotoxin-deficient mutant of a member strain of the Bacillus cereus group does not produce HBL enterotoxin, which has been regarded as a human pathogen found in member strains. An...
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6602503 |
Recombinant anti-VLA-4 antibody molecules
The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific...
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6599876 |
Medicament and method for treating renal disease
A medicament for treating a renal disease, comprising a therapeutically effective amount of an activin inhibitor as an active ingredient. Also, a method for treating a renal disease, comprising...
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6596541 |
Methods of modifying eukaryotic cells
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells....
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6596516 |
Process for the fermentative preparation of L-amino acids using coryneform bacteria
A process for the preparation of L-amino acids, in which the following steps are carried out, a) fermenting the desired L-amino acid-producing bacteria in which at least the glyA gene is...
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6596539 |
Modification of virus tropism and host range by viral genome shuffling
The invention relates to a method and compositions for modifying a phenotype of a virus, such as viral tropism and host range, by iterative sequence recombination of variant viruses and selection...
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6593141 |
Scorpion toxins
This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel modifiers. The invention also relates to the construction of a chimeric gene encoding all or...
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6586184 |
Chimeric mutational vectors
The invention is based on the discovery that recombinagenic oligonucleobases are active in prokaryotic cells that contain a strand transfer activity (RecA) and mismatch repair activity (MutS)....
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6586251 |
Methods of modifying eukaryotic cells
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells....
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H002071 |
Streptococcus pneumoniae gene HI0454
The invention provides isolated nucleic acid compounds encoding the 454 gene of Streptococcus pneumoniae . Also provided are vectors and transformed host cells for expressing the encoded protein,...
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6586240 |
Visualization of RNA in living cells
A method for visualizing the location and movement of a specific RNA of interest in a living cell, in real time, is disclosed. The method includes the following steps: (a) providing a DNA encoding...
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6586216 |
Deregulation of glutamine PRPP amidotransferase activity
The present invention is directed to a modified amidotransferase. The amino acid sequence of the modified amidotransferase differs from the amino acid sequence of a native E. coli glutamine PRPP...
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6582951 |
Method for non-homologous transformation of Yarrowia lipolytica
The invention concerns the integration of a gene of interest into the genome of a Yarrowia strain devoid of zeta sequences, by transforming said strain using a vector bearing zeta sequences.
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6582910 |
WbpP and method for assay of WbpP
Novel nucleic acid molecules that are associated with WbpP epimerase which is associated with bacterial infection are disclosed. Proteins encoded by the nucleic acid molecules and antisense...
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6576467 |
Methods for producing recombined antibodies
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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6576454 |
Modified enzymes and their use for peptide synthesis
The present invention relates to modified enzymes with one or more amino acid residues from an enzyme being replaced by cysteine residues, where at least some of the cysteine residues are modified...
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