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7109295 |
Zinc finger-based drug-dependent gene regulation system
The invention is related to a fusion polypeptide involving transcription regulation of a target gene. Said fusion polypeptide consists of (i) a zinc finger domain that recognizes and binds to the...
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7109010 |
Methods and materials for the synthesis of organic products
This invention provides biocatalysts that are recombinant yeast cells comprising recombinant expression vectors encoding heterologous lactate dehydrogenase genes for producing lactate.
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7109009 |
Regulatory region of the CYP52A2A gene from Candida tropicalis
Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells...
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7109008 |
L-glutamate oxidase
The present invention provides a novel L-glutamate oxidase, a gene encoding the enzyme, and a method for producing the enzyme. By use of a gene encoding the enzyme, L-glutamate oxidase can be...
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7105297 |
Methods and compositions for cellular and metabolic engineering
The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination....
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7105323 |
Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant DNA
The present invention relates to a precious metal-recombinant apoferritin complex produced by recombination technique, wherein the precious metal is gold (Au) or platinum (Pt), and wherein the...
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7105348 |
Methods of modifying eukaryotic cells
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells....
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7101696 |
Polyhydroxyalkanoate synthase and gene encoding the same enzyme
A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase...
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7098010 |
Directed evolution of oxidase enzymes
This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantagoeusly produced...
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7087418 |
Pichia pastoris formate dehydrogenase and uses therefor
This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide...
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7083960 |
Production of a highly active, soluble form of the cytochrome P450 reductase (CPR A) from Candida tropicalis
The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal...
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7081341 |
Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance
Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would...
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7078204 |
Glucose-6-phosphate dehydrogenase
The present invention relates to a novel glucose-6-phosphate dehydrogenase (hereinafter referred to as “G6PD”) derived from a bacterium belonging to the genus Corynebacterium , a DNA encoding...
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7078389 |
Chemically modified oligonucleotide for site-directed mutagenesis
A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid...
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7074757 |
Method and device for improving protein stability and solubility
A method for expressing proteins as a fusion chimera with a domain of p26 or alpha crystallin type proteins to improve the protein stability and solubility when over expressed in bacteria such as ...
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7070960 |
Method of increasing product expression through solute stress
A method of determining the optimal level of product expression and cell growth of animal cell culture is described. The method generally comprises culturing cells under conditions of solute...
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7070771 |
Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including...
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7070974 |
Metalloproteases of the neprilysin family
In this paper, we describe RT-PCR strategies that allowed us to identify and clone members of the NEP-like family. Degenerate oligoncleotide primers corresponding to consensus sequences located on...
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7067287 |
Method for recovery of nucleic acids
Methods for the recovery of nucleic acids from a nucleic acid-containing material are provided, by which nucleic acids can be rapidly and easily recovered at a high purity without deteriorating the...
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7067245 |
Selection methods
A rational method for obtaining a novel molecule capable of a desired interaction with a substrate of interest comprising selecting hosts or replicators which encode said novel molecules based upon...
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7060669 |
Process for partitioning of proteins
The present invention relates to isolation and purification of proteins in aqueous two-phase systems (ATPS). Specifically the invention provides processes for partitioning of proteins of interest...
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7060480 |
MRE11 orthologue and uses thereof
The invention provides isolated Mre11 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Mre11 levels in plants. The invention...
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7060481 |
Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention...
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7056740 |
Mismatch endonucleases and methods of use
We describe here restriction endonucleases and their uses. Restriction endonucleases are useful in finding single nucleotide polymorphisms. They are also useful in an in vitro method of...
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7056728 |
Compositions and methods for use thereof in modifying the genomes of microorganisms
The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other...
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7052900 |
Saccharomyces cerevisiae yeast strain with functional expression of a Glut transporter
The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no...
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7053046 |
Peptide activators of VEGF
The invention provides peptide inhibitors that inhibit ubiquitination of hypoxia inducible factor 1 alpha (HIP 1-α) and thereby activate transcription of erythropoietin (EPO), vascular endothelial...
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7049122 |
Mutant-type lipases and applications thereof
The present invention provides mutant-type lipases which demonstrate superior lipolytic and esterific activities. The mutant-type lipases are characterized by an amino acid alteration at the...
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7049142 |
Gene expression with covalently modified polynucleotides
A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can...
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7045325 |
32142, 21481, 25964, 21686, novel dehydrogenase molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense...
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7045324 |
Tocopherol associated protein and uses thereof
The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides...
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7037510 |
Hybrids of M. tuberculosis antigens
The present invention discloses fusion proteins of the immunodominant antigens ESAT-6 and Ag85B from Mycobacterium tuberculosis or homologues thereof, and a tuberculosis vaccine based on the...
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7037696 |
Truncated form of fibrobacter succinogenes 1,3-1, 4-β-d-glucanase with improved enzymatic activity and thermo-tolerance
A truncated glucanase with an improved thermal stability and a higher specific enzymatic activity than the wild-type enzyme. The truncated glucanase is obtained by removing a number of amino acid...
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7033806 |
HY2 family of bilin reductases
This invention identifies a novel family of bilin reductases. Designated herein HY bilin reductases, the enzymes of this invention are useful in a wide variety of contexts including but not limited...
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7033613 |
Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant DNA
Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic...
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7029888 |
Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate
The present invention relates to a modified enzyme of a non-heme iron (II) dependent family of oxygenases and oxidases which renders the enzyme dependent on bicarbonate for activity. In a preferred...
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7029895 |
27411, a novel human PGP synthase
The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC 17, NARC 25, NARC 3,...
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7022525 |
Process of making a compound by forming a polymer from a template drug
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for...
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7022319 |
Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral...
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7022826 |
Non-oligomerizing fluorescent proteins
A non-oligomerizing fluorescent protein, which is derived from a fluorescent protein having at least one mutation that reduces or eliminates the ability of the fluorescent protein to oligomerize,...
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7019123 |
Human bikunin
The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental...
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7009045 |
Transformation systems for flavinogenic yeast
This invention is directed to the transformation of the flavinogenic yeasts, Pichia guilliermondii and Candida famata , and mutants thereof, by electroporation (electrotransformation) and by...
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7005283 |
Cytochrome P450 oxygenases and their uses
Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol™), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic...
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7001751 |
PyrF gene and the utilization thereof
A pyrF gene is useful as a selection marker gene for an expression system for the production of proteins in mushrooms of the genus Trametes, Coriolus or Polyporus . The pyrF gene includes a DNA...
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7001882 |
Muteins of bilin-binding protein
The present invention relates to muteins of the bilin-binding protein with binding activity to digoxigenin and to fusion proteins of such muteins, a method for preparing said muteins and fusion...
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7001770 |
Calpain inhibitors and their applications
The present invention provides a method to enhance apoptosis in a cell by the administration of p53 in combination with a calpain inhibitor. The present invention provides a method of increasing...
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RE38981 |
DNA sequence coding for protein C
Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors...
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6995255 |
Cellular delivery agent
One aspect of the present invention relates to a nucleic acid construct which includes a first nucleic acid and a second nucleic acid operatively coupled to the first nucleic acid. The first...
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6984509 |
Steroid dehydrogenase 34 and the polynucleotide encoding same
The present invention discloses a novel polypeptide, a steroid dehydrogenase 34, the polynucleotide encoding the polypeptide and the method for producing the polypetide by DNA recombinant...
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6984490 |
Identification of genes
A method for identifying a microorganism having a reduced adaptation to a particular environment comprising the steps of:
(1) providing a plurality of microorganisms each of which is...
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