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7217571 |
Gene therapy by small fragment homologous replacement
A method for gene therapy using small fragment homologous replacement. The method introduces small fragments of exogenous DNA into regions of endogenous genomic DNA virtually homologous to the...
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7211420 |
Process for oxidizing terpenes
A process for oxidizing a substrate which is an acyclic or cyclic terpene, or a cycloalkene; or a substituted derivative thereof, which process comprises oxidizing said compound with a mutant...
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7208317 |
In Vitro mutagenesis, phenotyping, and gene mapping
Cellular libraries useful for in vitro phenotyping and gene mapping. In a representative approach, a method for preparing a homozygous cellular library includes the steps of providing a...
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7208293 |
Directed evolution of novel binding proteins
In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal...
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7202069 |
(R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes
This invention provides (R)-2-octanol dehydrogenase that catalyzes oxidation-reduction reaction using NAD + (NADH) as a coenzyme and the genes that encodes them. The enzymes of this invention can...
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7202086 |
Method for massive directed mutagenesis
The invention concerns the field of molecular biology and more particularly that of mutagenesis. It concerns a method of high-rate directed mutagenesis, that is the formation of numerous directed...
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7196187 |
Method for producing antibody fragments
An expression library comprising a repertoire of nucleic acid sequences cloned from a non-immunised source, each nucleic acid sequence encoding at least part of a variable domain of a heavy chain...
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7195900 |
Cloning and expression of D-amino acid oxidase from arthrobacter protophormiae
The present invention is directed to a nucleotide sequence encoding D-amino oxidase (D-AAO, EC 1.4.3.3) from Arthrobacter protophormiae. This may be inserted into an expression and used to...
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7196244 |
Method of transposon-mediated mutagenesis in the nematode caenorhabditis elegans
The present invention provides methods for generating and identifying mutations in Caenorhabditis elegans . Disclosed herein are methods for introducing DNA into the C. elegans germline, methods...
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7192758 |
Polynucleotides encoding phosphoribosylanthranilate isomerase
This invention relates to isolated nucleic acid fragments encoding phosphoribosylanthranilate isomerases, a tryptophan biosynthetic enzyme. The invention also relates to the construction of a...
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7192772 |
Recombinant cells that highly express chromosomally-integrated heterologous gene
Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an...
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7186795 |
Lactoferricin gene and transformant expressing lactoferricin
Disclosed is a gene encoding a mutated lactoferricin peptide and an E. coli cell transformed with the same, wherein the mutated lactoferricin peptide has substitutions at the 7th and 10th amino...
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7186534 |
Potent inhibitors of human 9-cis retinol dehydrogenase
The cDNA sequence of the human 9-cis-retinol dehydrogenase enzyme is disclosed.
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7179627 |
Cyclooxygenase variants and methods of use
The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring...
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7179473 |
Attenuated pestiviruses
This invention relates to attenuated pestiviruses characterised in that their enzymatic activity residing in glycoprotein E RNS is inactivated, methods of preparing, using and detecting these.
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7179626 |
11-Arachidonate-lipoxygenase mutants
A method for producing a plant lipoxygenase (LOX) with modified positional specificity toward arachidonic acid and its use for hydroperoxylation of arachidonic acid. The LOX makes it possible to...
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7176005 |
Modulation of sulfate permease for photosynthetic hydrogen production
Sustained hydrogen production is obtained by the culturing of a genetically-modified algae, where the ability of the chloroplasts to intake sulfate is reduced or eliminated compared to wild-type...
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7176009 |
Sucrose phosphate synthase
This invention relates to an isolated nucleic acid fragment encoding a sucrose phosphate synthase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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7176025 |
Methods for generating double stranded DNA comprising a 3′ single stranded portion and uses of these complexes for recombination
Methods of recombining nucleic acids are provided. In particular, methods for the production of partially double stranded nucleic acids comprising a 3′ overhang from an RNA target and use in...
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7176021 |
Mutant cells with altered sialic acid
The invention provides cells useful to propagate influenza virus mutants having reduced sialidase activity.
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7173007 |
Therapy for microbial infections
The disclosure provides a novel class of cationic cathelin-like peptides and polypeptides that have antimicrobial activity. These peptides are useful for inhibiting microbial infection or growth.
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7172894 |
Reductase gene and use of the same
A gene containing a DNA having the nucleotide sequence encoding any one of the amino acid sequences of the following (a) to (e):
(a) an amino acid sequence set out in SEQ ID NO: 1; (b) an...
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7172901 |
Scorpion toxins
This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel agonists. The invention also relates to the construction of a chimeric gene encoding all or a...
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7169964 |
Genetic control of organ abscission
A method for decreasing the rate of organ or floral abscission is described. The method includes modifying the ARF GAP domain of a gene. In one instance the gene is the NEVERSHED gene.
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7166466 |
Method for creating polynucleotide and polypeptide sequences
The invention provides methods for evolving a polynucleotide toward acquisition of a desired property. Such methods entail incubating a population of parental polynucleotide variants under...
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7166467 |
Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The...
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7163814 |
Modified reductase and its gene, and use thereof
There is provided a reductase characterized by
(i) an amino acid sequence of SEQ ID NO:1 having a substitution at amino acid position 54 or 104 or at both of the amino acid positions 54 and...
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7163816 |
Alpha-amylase variants
The present invention relates to a method of constructing a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and at least one altered property as compared...
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7163804 |
Non-toxic non-toxigenic non-pathogenic fusarium expression system
The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid...
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7163810 |
Method for producing target substance
In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate...
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7163820 |
Escherichia coli strain for an oral vaccine against post-weaning diarrhea in pigs
The invention relates to a strain suitable for producing a live, orally applicable Escherichia coli vaccine for the prevention of post-weaning diarrhoea in pigs, and the procedure suitable for...
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7163791 |
α,2,8-sialyltransferase
The invention provides a novel α-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-2,8-sialyltransferase, a method of detecting, or suppressing the...
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7160708 |
Fatty alcohol oxidase genes and proteins from Candida tropicalis and methods relating thereto
The present invention provides fatty alcohol oxidase (FAO) proteins and nucleic acid molecules encoding the FAO proteins. Also provided are analogs, derivatives, and enzymatically active fragments...
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7157566 |
Monomeric and dimeric fluorescent protein variants and methods for making same
The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention...
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7148065 |
Non-toxic immune stimulating enterotoxin compositions
Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced...
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7141721 |
Enoyl-ACP reductases
This invention relates to an isolated nucleic acid fragment encoding corn ( Zea maize ) and soybean ( Glycine max ) enoyl-ACP reductase. The invention also relates to the construction of a...
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7141401 |
COX1-interacting proteins and use thereof
Protein complexes are provided comprising COX1 and one or more proteins selected from the group consisting of THR S14 and Opa1. The protein complexes are useful in screening assays for identifying...
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7135318 |
Modified reductase and its gene
There are disclosed a reductase having good heat stability, which resulted in decrease in reaction time and improvement of reaction efficiency. Specifically, disclosed is an enzyme having an amino...
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7132273 |
Cell wall anchor proteins derived from yeast, genes thereof and cell surface expression systems using the same
The present invention provides novel cell wall anchor proteins derived from yeast, genes thereof and the genetic method for tethering polypeptide to the yeast cell wall using the same....
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7129055 |
Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was...
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7125695 |
Directed evolution of microorganisms
The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses...
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7122195 |
Mutant mycobacteria for use in therapy
This invention relates to recA mutant mycobacteria, particularly mutants of mycobacterial species which are members of the Mycobacterium tuberculosis complex, such as M. bovis BCG and M....
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7122359 |
Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnatural” UDP- and TDP-nucleotide sugars
The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which...
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RE39352 |
Creatine amidinohydrolase, production thereof and use thereof
A creatine amidinohydrolase having the following physicochemical properties:
Action: catalyzing the following reaction;
creatine+H 2 O→sarcosine+urea
Optimum...
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7118915 |
Muteins of apolipoprotein D
A method for generating a mutein of human apolipoprotein D having detectable affinity to a given non-natural ligand of apolipoprotein D is disclosed, which comprises the steps of: (a) subjecting...
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7119077 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to...
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7118902 |
Modified ADAMTS4 molecules and method of use thereof
The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and...
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7115725 |
Multi-mutant diphtheria toxin vaccines
Disclosed is DNA encoding diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
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7115403 |
Directed evolution of galactose oxidase enzymes
This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantageously produced...
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7112417 |
Foam composite for the repair or regeneration of tissue
The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition...
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