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5932446 |
HMVAB41
HMVAB41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMVAB41 polypeptides and...
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5928920 |
Threonyl tRNA synthetase from Staphylococcus aureus
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are...
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5928866 |
Method for preparing mutant genes
This invention provides A method for preparing mutant genes, which comprises the steps of constructing a recombinant plasmid DNA by inserting a gene fragment into a plasmid DNA having a...
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5928947 |
Mammalian multipotent neural stem cells
The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable...
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5925540 |
Synthetic antifreeze peptide and synthetic gene coding for its production
A synthetic antifreeze peptide and a synthetic gene coding for the antifreeze peptide have been produced. The antifreeze peptide has a greater number of repeating amino acid sequences than is...
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5922687 |
Intracellular delivery of nucleic acids using pressure
Naked nucleic acids (DNA, RNA, and/or analogs), drugs, and/or other molecules in an extracellular environment enter cells in living intact tissue upon application of pressure to the cells and...
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5922928 |
Genetic transformation and regeneration of plants
An Agrobacterium-mediated transformation and regeneration method for plants including a transformation method to produce transgenic plants with an altered lignin composition.
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5912236 |
Broad-spectrum tumor suppressor genes gene products and methods for tumor suppressor gene therapy
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate host cells. The protein is a second in-frame AUG codon-initiated...
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5898097 |
Resistance to virus infection using modified viral movement protein
The present invention relates to the methods and nucleic acid compositions for the production of transgenic plants resistant to virus infection. In particular, it relates to transgenic plants...
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5891859 |
Method for regulating cold and dehydration regulatory genes in a plant
A gene, designated as CBF1, encoding a protein, CBF1, which binds to a region regulating expression of genes which promote cold temperature and dehydration tolerance in plants is described. CBF1 is...
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5888817 |
Pituitary differentiaton factor and methods of use thereof
The present invention is directed to pituitary differentiation factor (PDF), a pituitary factor that is capable of differentiating cells including breast cancer and prostatic cancer cells. Isolated...
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5888800 |
Expression systems for commercial production of cellulase and xylanase in Bacillus subtilis and Bacillus licheniformis
Increased production of a heterologous cellulase is achieved by transforming Bacillus subtilis and Bacillus licheniformis with genetic constructs containing a Bacillus licheniformis ATCC 53926...
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5888498 |
Cellular and animal models for diseases associated with mitochondrial defects
Cybrid cell lines which have utility as model systems for the study of disorders that are associated with mitochondrial defects are described. The cybrids are constructed by treating immortal cell...
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5885810 |
Process for the production of prenyl diphosphate using mutants of geranylgeranyl diphosphate synthase
The present invention discloses a mutated enzyme comprising a geranylgeranil diphosphate synthase having its origin in wild type Sulfolobus acidocaldarius wherein at least one of phenylalanine at...
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5869306 |
Gene transfer preparation
A process for producing a gene transfer preparation which comprises adding one or more additives selected from among arginine, glutamic acid or its sodium salt, serine, glucose, inositol, lactose,...
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5866385 |
Lactic acid bacterial suppressor mutants and their use as selective markers and as means of containment in lactic acid bacteria
Methods of isolating nonsense suppressor-encoding lactic acid bacteria, cultures and compositions of lactic acid bacteria and plasmids comprising a gene coding for a nonsense suppressor, and a...
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5866421 |
Enhanced expression in a plant plastid
Novel compositions and methods useful for genetic engineering of plant cells to provide increased expression in the plastids of a plant or plant cell of a protein which produces a phenotype which...
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5859224 |
Base sequence of the coat protein gene of papaya leaf-distortion mosaic virus
The present invention discloses a genomic RNA of papaya leaf-distortion mosaic virus (PLDMV) having the base sequence shown in SEQ ID NO: 1 and a DNA complementary to the above RNA having the base...
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5856126 |
Peptide having anti-thrombus activity and method of producing the same
A multimer peptide from a snake venom has an activity to inhibit binding between von Willebrand factor and platelets. The multimer peptide is used to obtain a single strand peptide which does not...
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5853735 |
Avirulent anti-rabies vaccine
The invention relates to an avirulent anti-rabies vaccine which consists of an avirulent mutant of an SAD strain of the rabies virus, the glycoprotein of which possesses in position 333 a naturally...
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5840532 |
Neuronal bHLH-PAS domain proteins
The invention provides methods and compositions relating to neuronal PAS domain proteins (NPAS) and related nucleic acids. The proteins may be produced recombinantly from transformed host cells...
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5798236 |
Synthesis of quinic acid from glucose
There are described methods for the synthesis of quinoid organic compounds from a renewable energy source such as glucose. The method comprises enhancing the amount of glucose equivalents...
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5798234 |
Method for the directed modification of enzymes, modified enzymes and their use
Enzymes with modified substrate specificity and methods of obtaining same by the steps of a) determining the structure of two or more enzymes in the same group, b) comparing the structure of the...
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5798226 |
Yeast host strains with defects in N-glycosylation
Saccharomyces mutants with defects in N-glycosylation which are obtainable by 3 H!-mannose suicide selection, introduction of one or several selective markers, selection of those strains which,...
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5770788 |
Inducing chromosome doubling in anther culture in maize
Fertile corn plants are produced by culturing anthers or pollen in the presence colchicine which is added to an otherwise ordinary anther culture medium after a pre-culture phase in the absence of...
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5702931 |
Mutagenesis methods and compositions
Methods and reagents for oligonucleotide-directed mutagenesis of a target nucleic acid are provided. In these methods a mutagenic oligonucleotide introduces a desired mutation at one site and, at a...
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5670351 |
Methods and compositions for the ex vivo replication of human hematopoietic stem cells
Methods, including culture media conditions, which provide for ex vivo human stem cell division and stable genetic transformation and/or the optimization of human hematopoietic progenitor cell...
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5660980 |
Methods for identifying and isolating variant T4 DNA polymerases
Method for identifying and isolating variant T4 DNA polymerase by isolating and selecting for T4 strains having variant DNA polymerase defective in DNA replication, and at least one additional...
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5432079 |
Method for selecting mutants of legume-nodulating bacteria enhanced in competition
Methods for the isolation of mutant rhizobial strains with improved competition of nodulation (Comp + ) is presented. Mutants are selected for constitutive expression of inducible nod genes (in the...
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5348872 |
Method for isolating mutant cells
Disclosed is a method for isolating a mutant cell that secretes a desired compound at a level greater than that secreted by a starter cell from which the mutant cell is derived. The method includes...
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5272070 |
Method for the preparation of cell lines producing Man.sub.3 GlcN.sub.ac 2 asparagine-linked gylcans and cell lines produced thereby
Disclosed is the preparation of eukaryotic cells which are capable of producing smaller and less heterogenic N-linked glycans, particularly glycans having the structure Man 3 GlcNAc 2 . In...
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5125099 |
Obtaining heteropolysaccharide-producing microorganism and the microorganism agrobacterium radiobacter NCIB 40018
The invention provides a process for obtaining a second micro-organism by derivation from a first micro-organism, each micro-organism having the capability of producing an extra-cellular product...
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5114854 |
Process of effecting a microinjection into living cells
For a microinjection of liquids or suspensions of substances into living cells, a stage and a cannula, which is movably mounted and extends at an oblique angle relative to the stage, are arranged...
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5049503 |
Method for affecting fertility in plant variants
Plant embryogenesis from cultured, immature gametic cells can be exploited to overcome the problem of phenotypic sterility in the products of many techniques for plant modification, including...
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4966840 |
Stable high copy number plasmids
DNA plasmids are described which are selected mutants in which an altered repressor gene leads to high copy number replication. Elements in the plasmids are modified in such a way that readthrough...
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4889810 |
Method and compositions for improving the nutritive value of foods via Lactobacillus Ferementum
Mutant microorganisms comprising Lactobacillus ferementum Lex + which are obtained from Lactobacillus fermentum produce lysine in a significantly greater quantity than the wildtype microorganism....
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4857460 |
Cycloheximide resistant gene
A cycloheximide resistant gene of the present invention can be produced by cultivating yeast belonging to Candida genus and by cleaving a cycloheximide resistant gene from the yeast using...
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4837151 |
Live vaccines comprising two mutations and foreign antigen
Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification...
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4784952 |
Conferred susceptibility to lambda phage in non-coliform procaryotic hosts
Vectors suitable for effecting expression of lamB protein in a desired procaryotic host, and methods for their construction, are disclosed. Transformation with these vectors results in the ability...
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4770875 |
Process for preparation of improved mutant strain of Bordetella bronchiseptica useful for live attenuated vaccine for protection of B. bronchiseptica infection and live attenuated AR vaccine produced therefrom
A process for the preparation of a mutant strain of B. bronchiseptica having chromosomal genetic markers carrying at least temperature-sensitive (grown at 42° C.), nalidixic acid-resistant and...
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4720461 |
Succinate-sensitive, nodulation-enhancing Rhizobium mutants for use with legumes
Nodulation-enhancing mutants of Rhizobium species are prepared by growing a wild-type strain in a medium as the only carbon source at a sub-minimum concentration for normal growth, the mutant cells...
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4659670 |
Biological desulfurization of coal
A process for the preparation of microorganisms, ATCC No. 39327 which are capable of reproducible reduction of sulfur, particularly organic sulfur, in coal wherein the novel microorganisms are...
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4595660 |
Molecular cloning with bifunctional plasmid vectors in Bacillus subtilis, mutants and substantially stably transformed mutants of Bacillus subtilis, and methods for utilizing the transformed mutants
A mutant of Bacillus subtilis has been isolated which greatly facilitates gene cloning in this nonpathogenic microorganism. B. subtilis is a known protein secretor and can be used efficiently in...
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4544632 |
Human T cell lines and method of producing same
This invention provides a human parental T cell line which can fuse with normal human T cells, and hybrid cell lines which are prepared by fusion of the human parental T cells and the human T...
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4528269 |
Method for producing single and/or mixed strain concentrates of bacteria
An improved method which differentiates or separates heterogeneous populations of fast and slow acid producing strains of bacteria by growth of the strains under closely controlled unique...
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4521516 |
Strain of Clostridium acetobutylicum and process for its preparation
A novel asporogenic strain of Clostridium acetobutylicum is produced by growing a spore-forming strain in a continuous culturing reactor. Culturing is conducted at a dilution rate which prevents...
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4521515 |
Bacterial strain for purifying hydrocarbons pollution and purification process
A bacterial strain comprising a strain of Pseudomonas exhibits acceleration of growth in a logarithmic phase in a trophic culture medium when hydrocarbons are added thereto, a process for producing...
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4385120 |
Thermostable glycerokinases and process for its production
A thermostable glycerokinase enzyme useful in the detection and estimation of glycerol derivatives has a half-life in excess of 1 hour at 55° C. at a protein concentration of less than 2 mg/ml and...
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4376823 |
Method of increasing the antibiotic yield of producing organisms
A method of increasing the yield of a desired product, such as an antibiotic, by an organism which normally must first become inducibly resistant to that product before it can produce the product...
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4349569 |
Method of culturing Lactobacillus acidophilus
Lactobacillus acidophilus is cultured by special process steps to derive a strain of organisms having a length of over ten microns and a tough stable outer hide, and which produce high acidity...
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