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6335436 |
Oligonucleotides active against drug-resistant bacteria
The invention discloses methods and materials for the utilization of chemically modified oligonucleotides in the treatment of drug-resistant bacterial infections including drug-resistant tuberculosis.
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6331660 |
Maize DIMBOA biosynthesis genes
The identification of the maize Bx1 gene involved in benzoxazinone biosynthesis activity is described. This Bx1 gene, as well as other benzoxazinone biosynthesis genes, provide valuable tools for...
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6329573 |
Plants containing the gdhA gene and methods of use thereof
Plant nitrogen metabolism in corn and tobacco has been altered by transformation with a highly active assimilatory glutamate dehydrogenase gene. Plants containing the gdhA gene are resistant to...
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6326001 |
Recombinant vaccine for diseases caused by encapsulated organisms
Vaccines for diseases caused by normally encapsulated organisms are produced by genetically modifying those organisms by deleting the genes encoding for capsule synthesis or a portion thereof...
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6322787 |
Induction of an anti-tumor immunity by redirecting tumor cells against antigen-presenting cells
According to the invention, there is provided a human or animal cell expressing an antibody directed against a surface antigen on an antigen-presenting cell (APC) and lacking parental tumor-derived...
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6323395 |
Nucleotide sequences of maize and soybean β-Ketoacyl-Acyl Carrier Protein Synthase II and their use in the regulation of fatty acid content of oil
Genes encoding β-Ketoacyl-Acyl Carrier Protein Synthase II have been isolated from maize and soybean tissues. These proteins, when expressed in a plant, can alter the saturate levels of the oil.
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6322965 |
Chimera antigen peptide
A chimera antigen peptide containing the epitope regions in the core region, the NS3 region, and the NS4 region of the HCV polypeptide. A sensitive detection of a wide range of infection by...
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6316261 |
Method for concerted integration of donor DNA molecules using retroviral integrase proteins
A method of analysis of concerted integration in which viral integrase enzyme is first incubated with donor DNA molecules followed by incubation with target DNA molecules. The donor DNA molecule...
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6312957 |
Genetic modification of primate hemopoietic repopulating stem cells
Genetic modification of pluripotent hemopoietic stem cells of primates (P-PHSC) by transduction of P-PHSC with a recombinant adeno-associated virus (AAV). Tile genomc of the recombinant AAV...
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6312945 |
Human glutamate receptor proteins and associated DNA compounds
The present invention provides a human glutamate receptor and related DNA compounds useful not only in assays for potential pharmaceuticals but also in methods for molecular biology techniques.
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6312953 |
Bifunctional Crosslinking oligonucleotides adapted for linking to a target sequence of duplex DNA
Chemically modified oligonucleotides (ODNS) are complementary, either in the sense of the classic "four letter code" recognition motif, or in the sense required for triple strand formation based on...
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6313279 |
Human glutamate receptor and related DNA compounds
The present invention provides a human glutamate receptor and related DNA compounds useful not only in assays for potential pharmaceuticals but also in methods for molecular biology techniques.
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6309854 |
Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or...
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6303299 |
Vitro suppression as a tool for the investigation of translation initiation
The invention relates to a method for studying translation initiation and for identifying potential inhibitors of translation initiation by expressing proteins in the presence of misacylated...
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6303357 |
L-α-glycerophosphate oxidase gene, recombinant DNA, and method for producing modified L-α-glycerophosphate oxidase gene
This invention provides an L-α-glycerophosphate oxidase (GPO) having excellent properties such as stability, heat resistance and reactivity. A recombinant GPO obtained by replacing an amino acid...
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6303376 |
Methods of targeted mutagenesis using triple-helix forming oligonucleotides
A high affinity, triplex-forming oligonucleotide and methods for use thereof wherein an oligonucleotide is used to form a triple-stranded nucleic acid molecule with a specific DNA segment of a...
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6300317 |
Self-assembling polynucleotide delivery system
This invention provides a self-assembling polynucleotide delivery system comprising components aiding in the delivery of the polynucleotide to the desired address which are associated via...
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6300118 |
Plasmids comprising a genetically altered feline immunodeficiency virus genome
The present invention pertains to the prevention or lessening of disease in cats caused by Feline Immunodeficiency Virus (FIV). Prevention or lessening of disease is understood to mean the...
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6294382 |
Antisense modulation of SRC-1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of SRC-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6294358 |
Thermus promoters for gene expression
The present invention relates to a system for identifying, isolating and utilizing promoter elements useful for expression of nucleotide sequences and the proteins encoded thereby in a thermophile....
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6294716 |
Plants having modified response to ethylene by transformation with an ETR nucleic acid
The invention includes transformed plants having at least one cell transformed with a modified ETR nucleic acid. Such plants have a phenotype characterized by a decrease in the response of at least...
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6290972 |
Method of augmenting a vaccine response by administering CD40 ligand
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
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6287865 |
Cf-2 plant pathogen resistance genes
The tomato Cf-2 gene has been cloned and its sequence provided, along with the encoded amino acid sequence. DNA encoding the polypeptide, and alleles, mutants and derivatives thereof, may be...
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6284512 |
Chemically modified mutant enzymes and methods for producing them, and screening them for amidase and/or esterase activity
The present invention relates to a method for screening chemically modified mutant enzymes for amidase and/or esterase activity. This method includes providing a chemically modified mutant enzyme...
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6277639 |
Methods for multifragment sexual cloning and mutation mapping
The subject invention relates to a method referred to as multifragment in vivo cloning (MFIVC), or sexual cloning. In the method, the polymerase chain reaction or the cleavage by restriction...
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6277622 |
Synthetic polynucleotides
This invention relates to synthetic polynucleotides which encode lysyl oxidase, lysyl oxidase like molecules or variants of these species. The synthetic polynucleotides of the invention permit the...
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6274340 |
DNA sequences enhancing promoter activity
The present invention relates to a DNA comprising the nucleotide sequence shown in SEQ ID NO:1, or a DNA for enhancing promoter activity which comprises a nucleotide sequence having deletions,...
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6271000 |
Streptococcus pneumoniae gene sequence mraY
The invention provides isolated nucleic acid compounds encoding enzyme mraY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded enzyme, and...
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6271007 |
Yeast strains for the production of xylitol
The invention relates to novel yeast strains having a reduced ability to metabolize xylitol. The invention further relates to the use of said strains for the production of xylitol.
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6268140 |
Combinatorial metabolic libraries
The present invention provides methods and compositions for producing and screening combinatorial metabolic libraries of multimeric proteins. The present invention relies on the use of filamentous...
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6265177 |
Enzyme assay for mutant firefly luciferase
Enzymes and methods suitable for assaying ATP, and specific application for such assays are described and claimed. In particular, there is described a recombinant mutant luciferase having a...
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6265185 |
Yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
Novel yeast promoters for either EF1-alpha protein or ribosomal protein S7 gene suitable for expression cloning in yeast and heterologous expression of proteins in yeast. The yeast promoters are...
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6264915 |
Process for detecting potential carcinogens
A process for screening an agent to determine its effect upon the frequency of genome rearrangement in transgenic mammals. The process comprises the steps of: (a) providing a transgenic mammal into...
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6265552 |
Biotinylation of proteins
Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo...
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6261767 |
Method for the qualitative and quantitative detection of DNA damage
A method for the qualitative and quantitative detection of damages to DNA, characterised in that it includes the steps of binding the target DNA to a sensitised substrate, subjecting the DNA to the...
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6258565 |
Expression vectors based on RK2 and TOL plasmids
The present invention provides an expression vector comprising an RK2 minimum replicon together with an expression cassette comprising the regulatory functions of a TOL plasmid, and, in particular,...
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6258540 |
Non-invasive prenatal diagnosis
The invention relates to a detection method performed on a maternal serum or plasma sample from a pregnant female, which method comprises detecting the presence of a nucleic acid of foetal origin...
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6258603 |
Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
This invention relates to an improved method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation...
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6258769 |
Peroxidase variants with improved hydrogen peroxide stability
A variant of a Coprinus cinereus peroxidase having one or more substitutions selected from M166L, V, I, F, Q and M242L, V, I, F, Q, wherein the parent peroxidase is encoded by the DNA sequence...
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6255089 |
Constitutively activated serotonin receptors
Mutations have been discovered in mammalian G protein-coupled serotonin 5-HT 2A and 5-HT 2C receptors which render the mutated receptors constitutively active. An alignment methodology based on...
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6255112 |
Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
The invention relates to the induction of hematopoietic stem cells to differentiate into osteoclasts by culturing hematopoietic stem cells with human mesenchymal stem cells, and, in a preferred...
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6251675 |
Methods utilizing mutant rev genes encoding transdominant repressors of HIV replication
Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes are described, having the...
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6242217 |
h-TREK1 polypeptides and h-TREK1 polynucleotides
h-TREK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing h-TREK1 polypeptides and...
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6242234 |
Mutants of formate dehydrogenase from Candida boidinii, new gene sequences encoding these and use of the new formate dehydrogenases
The invention relates to new mutants of formate dehydrogenase from Candida boidinii, new gene sequences encoding these and use of the new formate dehydrogenases. The wild type FDH used hitherto in...
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6238923 |
Method for multifragment in vivo cloning and mutation mapping
The subject invention relates to a method referred to as multifragment in vivo cloning (MFIVC). In the method, the polymerase chain reaction or the cleavage by restriction enzyme(s) are used to...
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6235535 |
Fluorescent energy transfer ligand interaction assay on a lipid film
This invention relates to a fluorescence-based immunoassay method for the detection of an analyte, or for the measurement of its concentration in a biological sample. The method is based on the...
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6235524 |
Compositions and methods for screening agents that inhibit MAPK mediated anti-apoptotic signals
Nucleic acid sequences and corresponding translated products of novel mutant forms of the Drosophila hid gene are described. Such sequences and products are useful in screening methods for...
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6235510 |
ppGaNTase-T6
ppGaNTase-T6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ppGaNTase-T6 polypeptides...
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6232459 |
Synaptojanin isoform
The invention provides a human synaptojanin isoform (NSYN-1) and polynucleotides which identify and encode NSYN-1. The invention also provides expression vectors, host cells, agonists, antibodies...
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6228620 |
Protein complexes having factor VIII:C activity and production thereof
Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first...
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