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6444426 |
Production and use of normalized DNA libraries
Disclosed is a process for forming a normalized genomic DNA library from an environmental sample by (a) isolating a genomic DNA population from the environmental sample; (b) at least one of (i)...
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6440666 |
Selection for dwarfism in poultry
The invention relates to a gene located on chromosome 1 in chickens, which in birds is involved in so called autosomal dwarfism. The most likely candidate gene has a homolog in mice and men and is...
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6436681 |
Method for producing biotin
A gene construct comprising a biotin gene having the sequence SEQ ID No. 1 or SEQ ID No. 3, organisms which comprise this gene construct, the use of these sequences or of the gene construct for...
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6436657 |
Polynucleotides encoding aminomethyltransferases
This invention relates to an isolated nucleic acid fragment encoding a tetrahydrofolate metabolic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion...
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6436683 |
Human nucleic acid methylases
The invention provides a human nucleic acid methylases (HNAM) and polynucleotides which identify and encode HNAM. The invention also provides expression vectors, host cells, antibodies, agonists,...
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6433251 |
Promoter regulating circadian clock function and photoperiodism
Nucleic acid molecules that encode a plant promoter involved in photoperiodism and circadian rhythms are disclosed. These molecules may be introduced into plants in order to alter the photoperiodic...
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6429298 |
Assays for identifying functional alterations in the p53 tumor suppressor
The present invention provides for various screening assays which are amenable to high throughput formats and identify a variety of useful mutations in tumor suppressor genes such as p53. Such...
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6428985 |
Immunosuppressive structural definition of IL-10
Disclosed is the surprising discovery that a single amino acid provides the demarcation between the immunosuppressive and immunostimulatory properties of the cytokine, IL-10. The present invention...
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6426186 |
Bone remodeling genes
The invention provides polynucleotides and polypeptides that are co-expressed with genes known to be involved in bone remodeling and osteoporosis. The invention also provides expression vectors,...
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6423885 |
Methods for obtaining modified phenotypes in plant cells
Methods are provided for reducing the phenotypic expression of a nucleic acid of interest in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of...
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RE37806 |
Method of using eukaryotic expression vectors comprising the BK virus enhancer
The present invention is a method of using the BK enhances in tandem with a eukaryotic promoter to promote transcription of DNA that encodes a useful substance. The method of the present invention...
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6420345 |
Methods and reagents for inhibiting angiogenesis
Disclosed are methods for inhibiting angiogenesis using cyclin dependent kinase inhibitors (CDKi) and fusion proteins thereof, recombinant viruses comprising transgenes and nucleic acid sequences...
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6420144 |
Method for automated molecular cloning
A method for the automated molecular cloning and amplification of closed circular clones in vitro in a cell-free system using a pair of particularly designed cloning primers in a...
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6413765 |
Genetically modified lactic acid bacteria having modified diacetyl reductase activities
Genetically modified lactic acid bacteria having a reduced or lacking or enhanced diacetyl reductase activity, acetoin reductase activity and/or butanediol dehydrogenase activity are provided. Such...
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6410285 |
Alanyl tRNA synthetase from Streptococcus pneumoniae
The invention provides alaS polypeptides and DNA (RNA) encoding alaS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing alaS...
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6410286 |
Asparaginyl tRNA synthetase from Staphylococcus Aureus
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are...
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6410023 |
Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene
Recombinant parainfluenza virus (PIV) are provided in which expression of the C, D and/or V translational open reading frame(s) (ORFs) is reduced or ablated to yield novel PIV vaccine candidates....
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RE37767 |
Highly stable recombinant yeasts for the production of recombinant proteins
Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector...
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6410243 |
Chromosome-wide analysis of protein-DNA interactions
The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a...
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6406901 |
TNF-a converting enzyme
A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of...
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6407316 |
Method of increasing foreign protein expression
A method of increasing protein expression encoded by a foreign gene in plants which comprises treating a locus comprising the plant or the seed from which it grows with aldicarb. A method of...
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6406891 |
Dual RT procedure for cDNA synthesis
The present invention provides methods and compositions for the synthesis of long cDNA species. More particularly the present invention employs cycling between a low temperature and a high...
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6406896 |
Transposase enzyme and method for use
Modified Tn5 transposase proteins having a preference for transposon Tn5 inside ends rather than outside ends are disclosed and can be used in combination with a transposase enzymes that prefer...
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6407208 |
Chimeric proteins with a cellulose binding domain
Chimeric proteins containing a cellulose binding domain (CBD) situated between two independent desired proteins of different lengths can be contemplated for use in a wide range of applications. In...
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6403100 |
Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated
This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by eliminating or by downregulating the expression of the α-crystallin...
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6399760 |
RP compositions and therapeutic and diagnostic uses therefor
The present invention, which is based on the discovery of novel genes encoding rp polypeptides, features therapeutics, diagnostics and screening assays.
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6391642 |
Transformation-associated recombination cloning
The invention is directed to a method of making a yeast artificial chromosome (YAC) comprising introducing into yeast cells a population of nucleic acids and a vector, wherein the vector comprises...
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6392119 |
Two component plant cell lethality methods and compositions
The present invention is directed to methods for inhibiting the growth or killing cell in an organism, particularly plants. Genetically engineered cells and which allow for killing or provision of...
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6391641 |
Translationally-coupled reporter gene
A method of selecting for missense mutants that express a protein is disclosed. The method comprises constructing an operon comprising an upstream gene and a downstream reporter gene, wherein the...
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6391599 |
Sham-sensitive terminal oxidase gene from xylose-fermenting yeast
Disclosed is a SHAM-sensitive terminal oxidase (STO) gene from the xylose-fermenting yeast Pichia stipitis . Also disclosed is a mutant of Pichia stipitis in which the STO gene natively present...
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6391640 |
Methods and compositions for cellular and metabolic engineering
The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination....
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6387675 |
Mutant luciferases
The invention provides active, non-naturally occurring mutants of beetle luciferases and DNAs which encode such mutants. A mutant luciferase of the invention differs from the corresponding...
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6379964 |
Evolution of whole cells and organisms by recursive sequence recombination
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of...
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6372501 |
Glucose responsive β-cell line
The present invention provides an immortalized insulin producing human β-cell which may be rendered glucose responsive by suitable bioengineering methods. The invention also provides a method for...
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6368805 |
Methods of producing polynucleotide variants
A method for the construction of a library of recombined polynucleotides from a number of different starting single or double stranded parental DNA templates is disclosed, wherein the starting...
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6365725 |
DNA coding for a human vasoconstrictive peptide and use thereof
Disclosed are (1) a DNA containing a cDNA segment coding for human endothelin-2 (SEQ ID NO:1), (2) a precursor of human endothelin-2 (SEQ ID NO:2), (3) a transformant carrying a DNA containing a...
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6365408 |
Methods of evolving a polynucleotides by mutagenesis and recombination
A method of mutating a polynucleotide such that it has a desired or improved functional property is disclosed.
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6358742 |
Evolving conjugative transfer of DNA by recursive recombination
The invention provides a number of strategies for transferring and/or evolving gene(s) associated with cellular DNA uptake so that they confer or enhance DNA-uptake capacity of a recipient cell....
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6355484 |
Methods and compositions for polypeptides engineering
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are...
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6355861 |
Production of gamma linolenic acid by a &Dgr 6-desaturase
Linoleic acid is converted into γ-linolenic acid by the enzyme Δ6-desaturase. The present invention is directed to isolated nucleic acids comprising the Δ6-desaturase gene. More particularly,...
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6350587 |
Bacillus strain and antibiotic screening method
A Bacillus strain has a chromosome with the following modifications: a mutation of a spoIIIE gene which blocks transfer of the prespore chromosome; a mutation which prevents loss of SpoOJ function...
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6348577 |
Regulation of aureobasidin sensitivity in fungus
The present invention provides a protein regulating the sensitivity of fungus to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the...
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6344356 |
Methods for recombining nucleic acids
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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6344327 |
Methods for isolation of thermophile promoters
The present invention relates to a system for identifying, isolating and utilizing promoter elements useful for expression of nucleotide sequences and the proteins encoded thereby in a thermophile....
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6342373 |
Process for preparing recombinant eglin, protease inhibitor
The invention relates to DNA sequences which code an eglin, expression plasmids containing such DNA sequences, hosts transformed with such expression plasmids, novel eglin compounds produced from...
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6340592 |
Human cell lines
The invention relates to a method for producing human cell lines and cell and cell-lines produced by such a method. The method comprising the use of precursor or undifferentiated cells treated with...
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6340591 |
Integrative protein-DNA cochleate formulations and methods for transforming cells
An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide...
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6339150 |
Mutant rex genes encoding transdominant repressors of HIV/HTLV replication
Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of...
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6337200 |
Human telomerase catalytic subunit variants
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically active human telomerase...
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6337186 |
Method for producing polynucleotides with desired properties
The invention provides methods for the production of polynucleotides with a desired property (e.g., conferring a desired phenotype and/or encoding polypeptide with a desired property) which is...
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