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8114645 |
Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
The present invention provides methods of increasing production of an isoprenoid or an isoprenoid precursor in a host cell, the methods generally involving modulating the level of activity of a...
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6770455 |
Metal-containing ribonucleotide polypeptides
The present invention relates to metal-containing ribonucleotide polypeptides (RNP) and processes for their production, their use and medicaments containing ribonucleotide polypeptides or their...
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6503727 |
Process for the preparation of an antibiotic
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a...
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6391591 |
Biotechnological process for preparing N-acetylmannosamine
Novel microorganisms, which can be obtained by the following selection method: (a) microorganisms which grow using N-acetylglucosamine as the sole carbon source are cultivated in a customary...
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6383772 |
Enzymatic conversion in a solvent mixture containing water and flourinated, non-chlorinated solvent
A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms....
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6379922 |
Membrane enzyme reactor containing a plurality of biocatalyst-immobilized sheets
An enzyme membrane reactor is designed to enhance the production efficiency of foods, pharmaceutical products, and other bioproducts. The reactor is formed of a cap and a container in which a...
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6359200 |
Inbred corn plant 8M116
According to the invention, there is provided an inbred corn plant, designated 8M116. This invention thus relates to the plants and seeds of inbred corn plant 8M116 and to methods for producing a...
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6180360 |
Process of producing β-lactam antibiotics applying micro-organisms with increased ligase activity
The present invention relates to the biosynthesis of β-lactam antibiotics. More specifically, the invention relates to processes of producing β-lactam antibiotics in vivo and in vitro. Also c...
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6110699 |
Process for producing 6-amino-penicillanic acid and phenylacetic acid
Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate...
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6033823 |
Mutated penicillin G acylase genes
New mutant β-lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding said Penicillin G ...
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5902577 |
Insulin-secreting cell lines, methods of production and use
The invention relates to the field of biology and, in particular, to the field of cellular biology. The invention concerns a novel glucose-sensitive cell line designated β cell line (INS-I) ...
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5780260 |
Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier
An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an...
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5521068 |
Process for 7-aminodesacetoxycephalosporanic acid
The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin...
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5500352 |
Membrane filtration process for 6-aminopenicillanic acid
The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin...
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5268271 |
Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase
Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a ...
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5244790 |
Microorganisms for preparing traditional Korean soybean paste and the method for the production of soybean paste by using the same
The present invention relates to microorgaisms which produce the aroma and flavor of traditional Korean soybean paste. The present invention also relates to a method for producing the soybean paste...
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5215891 |
Process for preparing penems
A process for preparing a compound of formula I: ##STR1## wherein R1 represents a hydroxy protecting group and R2 represents a carboxy protecting group, which comprises: hydrolyzing a compound of...
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5079146 |
Method of protection of the carboxy groups in the chemistry of β-lactam compounds
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by ...
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4371612 |
Immobilization of biological material with an acrylonitrile polymer
Biological material such as enzymes is immobilized by adsorption or covalent bonding to a micro-porous water-insoluble acrylonitrile polymer containing from 20 μM to 1000 μM of amino groups per g...
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4370414 |
Process for producing 6-aminopenicillanic acid and 6-aminopenicillanic acid S-oxide
A process for producing 6-aminopenicillanic acid and 6-aminopenicillanic acid S-oxide by means of enzymes produced by microbes belonging to Arthrobacter genus, especially Arthrobacter cremorum and...
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4267273 |
Enzyme preparation having affinity for water-immiscible liquids
An enzyme preparation is prepared having terminal non-polar groups incorporated therein so that the enzyme preparation has affinity for a water-immiscible liquid. The enzyme preparation can be...
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4247643 |
Preparation of stabilized carrier-bound proteins
Stabilized carrier-bound protein is prepared by reacting a protein in aqueous solution with a mercapto group free, water insoluble carrier which contains binding groups which are reactive with the...
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4246346 |
Antibiotic and steroid transformation process
A method for activating immobilized living microorganisms applied to transformations of steroids, antibiotics and other compounds characterized by the addition of peptone, glucose or a mixture of...
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4113566 |
Process for preparing 6-aminopenicillanic acid
A simple and efficient process for the deacylation of penicillins to 6-aminopenicillanic acid in which an aqueous penicillin solution is rapidly recirculated through a shallow bed comprising...
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4053360 |
Enzymatic preparation of 6-D-(-)-α-amino-α-(p-hydroxyphenylacetamino)penicillin acid
This invention relates to a novel α-aminoα-(p-acyloxyphenyl)acetamidopenicillanic acid which is useful as an antibacterial agent, and also to a novel process for the production of 6...
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4048018 |
Method of carrying out enzyme catalyzed reactions
A liquid stream containing the reactants is passed through a bed of enzyme catalyst, made up of enzymes bonded to small, dense particles of carrier or support materials, in a manner which causes...
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4033817 |
Pressure-driven enzyme-coupled membranes
Pressure-driven enzyme-coupled membranes are prepared starting with a membrane filter having pores of appropriate, molecular dimensions and composed of a polymeric matrix, the activation of that...
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4001264 |
Enzyme complexes and their use
Novel water-insoluble enzyme complexes are provided which comprise a penicillin acylase enzyme adsorbed on a water-insoluble polymer substrate which is a polymer or copolymer of methacrylic acid...
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3953291 |
Process for preparing 6-aminopenicillanic acid
At least one acryloyl monomer is polymerized in an aqueous suspension containing a penicillin amidase-producing microorganism. The acryloyl monomers employed in the present invention include...
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3926728 |
New process for the preparation of 6-Aminopenicillanic acid
A useful intermediate, 6-Aminopenicillanic acid or its salt is prepared by the action of a fungus belonging to the genus Phialomyces, Leptosphaerulina, or Robillarda, or its mycelium preparation on...
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3925155 |
Preparation of 6-aminopenicillanic acid 1-oxide
6-Aminopenicillanic acid 1-oxide or its salt is prepared by the action of a microorganism belonging to the genus Streptomyces or its mycelium preparation on a penicillin 1-oxide or its salt.
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3915801 |
Process for preparing 6-aminopenicillanic acid
6-Aminopenicillanic acid or its salt is prepared from a penicillin or its salt by the action of a fungus belonging to the genus Pseudofusarium or its mycelium preparation.
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3910825 |
Water-insoluble peptide materials
Peptide materials such as enzymes and enzyme inhibitors are rendered water-insoluble by binding the peptide materials to a cross-linked copolymer formed by copolymerizing the following units: (A)...
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3905868 |
Enzymatic deacylation of benzyl- and phenoxymethylpenicillin tetrazoles
Deacylation of benzyl- and phenoxymethylpenicillin tetrazoles to produce 6-amino-2,2-dimethyl-3-(tetrazol-5-yl)penam by the use of selected deacylases. The process is useful in the purification of...
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3887432 |
6-Aminopenicillanic acid preparation
6-Aminopenicillanic acid is prepared by enzymatic degradation of benzylpenicillin or of phenoxymethylpenicillin at pH 6.0-9.0 using a novel water-soluble enzyme complex derived from a penicillin...
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3880713 |
Cephalosporin compounds
A process for the N-deacylation of a 7β-phenoxyacetamido cephalosporin which comprises subjecting the cephalosporin to the action of an amidohydrolase enzyme which is derived from a bacterial ...
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3871962 |
PENICILLIN ACYLASE
The enzyme, penicillin acylase, may be produced in high yield and possess high specific activity from cultures of penicillin acylase-producing microorganisms capable of hydrolytically splitting...
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3766009 |
PROCEDURE FOR ENZYMATIC PRODUCTION OF SEMI-SYNTHETIC PENICILLINS
A process for the enzymatic hydrolysing of diacyl-penicillins to semi-synthetic penicillins of the general formula: ##SPC1## The hydrolysis takes place in the presence of the enzyme...
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3622462 |
PROCESS FOR MANUFACTURE OF AN ENZYME PREPARATION
An improved process for the large-scale production of penicillin acylase wherein the purified, cell-free enzyme is prepared by fermenting an E. coli cell strain and separating the intracellular...
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3616223 |
PENICILLIN INTERMEDIATE
A more efficient process for the preparation of 6-amino-penicillanic acid has been devised which employs a penicillin amidase enzyme in the presence of a hydrazide compound. For example,...
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3737375 |
PROCESS FOR THE PRODUCTION OF 6-AMINOPENICILLANIC ACID
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3736230 |
PROCESS FOR PRODUCING 6-AMINO-PENICILLANIC ACID
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3455784 |
CONTROL OF ENZYME ACTIVITY IN FROZEN SYSTEMS
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3446705 |
METHOD FOR THE PRODUCTION OF 6-AMINO-PENICILLANIC ACID
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3337415 |
Method of preparing 6-amino-penicillanic acid
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3305453 |
Conversion of penicillin v to 6-aminopenicillanic acid by the use of spores
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3298924 |
Process for making penicillin amidase
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3297546 |
Preparation of 6-aminopenicillanic acid
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3278391 |
Process for producing an enzyme system capable of degrading penicillin g to 6-apa using a quaternary ammonium halide
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3272715 |
Method for producing and recovering 6-aminopenicillanic acid
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