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7241588 Method for producing novel β-lactam antibiotic from protoplast fusion strain  
The present invention provides a method for producing a novel β-lactam antibiotic from a protoplast fusion strain. The method is to fermentatively culture the protoplast fusion strain of ...
7229784 Modulation of secondary metabolite production by zinc binuclear cluster proteins  
Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods...
7053204 Global regulator of secondary metabolite biosynthesis and methods of use  
The invention provides polypeptides and nucleic acids which identify and encode LaeA, a regulator of fungal secondary metabolite production which exhibits global control over secondary metabolite...
6974675 Process for identifying and enriching cell-specific target structures  
This invention relates to a process for identifying and enriching cell-specific target structures, in particular for the identification of cell-specific protein combination patterns on the surface...
6949356 Methods for improving secondary metabolite production in fungi  
The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by...
6924115 Process for identifying cell-specific target structures  
This invention relates to a process for identifying cell-specific target structures. The process comprises automatically depositing a reagent solution that includes at least one marker molecule on...
6642035 Synthesis of B-keto esters  
β-keto esters are prepared by way of a lipase-catalyzed transesterification. The synthetic methodology provides a simple scheme for the synthesis of optically active β-keto esters that are useful...
6518039 Process for the fermentative production of deacylated cephalosporins  
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
6503727 Process for the preparation of an antibiotic  
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a...
6383772 Enzymatic conversion in a solvent mixture containing water and flourinated, non-chlorinated solvent  
A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms....
6379922 Membrane enzyme reactor containing a plurality of biocatalyst-immobilized sheets  
An enzyme membrane reactor is designed to enhance the production efficiency of foods, pharmaceutical products, and other bioproducts. The reactor is formed of a cap and a container in which a...
6361982 Regulatory gene for clavulanic acid biosynthesis  
DNA comprising a regulatory gene for clavulanic acid biosynthesis. DNA is no greater than 7 kb in length and has the configuration of restriction sites shown in FIG. 1 or a fragment thereof. Use...
6317795 Dynamic modification of multimedia content  
A method and system for manipulating or modifying identifiable objects in a standard broadcast or Internet-based multimedia stream according to a control specification and a content specification....
6287799 Process for the preparation of aβ-lactam antibiotic  
Process for the preparation of a β-lactam antibiotic in which a β-lactam nucleus is subjected to an enzymatic acylation reaction with the aid of an acylation agent at a molar ratio of acylation...
6258555 DNA encoding ACV synthetase  
DNA encoding the gene for the synthetase enzyme capable of generating δ (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and...
6251655 Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum by expression of the PCL gene  
An isolated DNA encoding phenyl acetyl-CoA-ligase and a process of increasing the production of penicillin G in a strain of Penicillium chrysogenum by transforming the strain with the isolated DNA....
6218138 Synthesis of beta-lactam antibiotics with immobilized penicillin amidase  
Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase...
6180360 Process of producing β-lactam antibiotics applying micro-organisms with increased ligase activity  
The present invention relates to the biosynthesis of β-lactam antibiotics. More specifically, the invention relates to processes of producing β-lactam antibiotics in vivo and in vitro. Also...
6159706 Application of enzyme prodrugs as anti-infective agents  
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate...
6156534 Synthesis of β-lactam antibacterials using soluble side chain esters and enzyme acylase  
Disclosed is a process for the synthesis of β-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said...
6110699 Process for producing 6-amino-penicillanic acid and phenylacetic acid  
Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate...
6100052 Process for the production of clavulanic acid and/or salts thereof by fermentation controlling soluble phosphate concentration  
6020151 Process for the production of 7-ADCA via expandase activity on penicillin G  
A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum...
5942411 Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity  
The present invention relates to the biosynthesis of β-lactam antibiotics. More specifically, the invention relates to processes of producing β-lactam antibiotics in vivo and in vitro. Also...
5922907 Precursors of β-lactam antibacterials having soluble side chain esters  
Disclosed is a process for the synthesis of β-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said...
5916762 Process for the recovery of ampicillin  
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from...
5882883 Process for the production of secondary metabolites  
The invention relates to an improved process for the production of a secondary metabolite comprising (i) fermentation of a microorganism capable of producing said secondary metabolite, and (ii)...
5882879 Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase  
Novel methods and compositions are provided for the enhanced production of β-lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P. chrysogenum and A....
5801011 Process for preparing cephalosporins with penicillin acylase without pH control  
The invention relates to an improved process for preparing cephalosporins by reaction compounds such as 7-amino-cephalosporanic acid, 7-amino-3-deacetoxy-cephalosporanic acid or their derivatives...
5780260 Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier  
An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an...
5695968 Process for production of D-α-amino acids  
The present invention is directed to a gene which is related to a D-N-carbamoyl-α-amino acid amidohydrolase which is an enzyme capable of converting D-N-carbamoyl-α-amino acids into D-α-amino...
5621096 Process for preparing penems  
The invention provides a process for the preparation of the compound of formula I ##STR1## wherein R is carboxy group or a carboxylate anion, by enzymatic hydrolysis with a lipase or an acylase in...
5521068 Process for 7-aminodesacetoxycephalosporanic acid  
The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin...
5474912 Method for increasing production of microbial metabolites by genetic engineering  
Targeted gene insertion methodology can increase the production of an antimicrobial metabolite and comprises the steps of: a) identifying the gene in unaltered chromosomal DNA which encodes an...
5472853 Enzymatic process for cephalosporins  
N-Terminal β,γ-didehydrovaline di- and tri-peptides are reacted with isopenicillin N synthetase to form 3-exomethylenecepham-4-carboxylic acids, e.g.,...
5468632 Recombinant DNA compounds and expression vectors encoding para-nitrobenzyl esterase activity from bacillus  
The present invention provides isolated DNA compounds and recombinant DNA cloning and expression vectors that encode PNB esterase from Bacillus subtilis. The invention also provides host cells...
5462862 Method and compositions for enhancing production of secondary metabolites using clustered biosynthetic genes  
Clustered antibiotic biosynthetic genes are employed for improvement of production of the antibiotic in microorganisms and for the isolation of other genes involved in the biosynthesis of the...
5407870 Process for fabricating a semiconductor device having a high reliability dielectric material  
A process for fabricating a high-reliability composite dielectric layer (19) includes the formation of a first oxynitride layer (14) on the surface (12) of a silicon substrate (10). The formation...
5364768 Process for the preparation of penems  
An in vitro process for preparing 6((1R)-hydroxyethyl) penem acids by hydrolyzing the carboxylic ester derivative thereof using an enzyme capable of selectively hydrolyzing the ester group at the...
5340483 Two step process for conversion of a weakly adsorbable compound to a strongly adsorbable compound and selective removal thereof  
A method for the selective separation of a particular compound from a mixture of compounds, by enzymatically converting a weakly adsorbable compound to a strongly adsorbable compound, and binding...
5268271 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase  
Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a...
5215891 Process for preparing penems  
A process for preparing a compound of formula I: ##STR1## wherein R 1 represents a hydroxy protecting group and R 2 represents a carboxy protecting group, which comprises: hydrolyzing a...
5079146 Method of protection of the carboxy groups in the chemistry of β-lactam compounds  
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by...
5013452 Resolution of emulsions formed in the production of pharmaceuticals  
A method for resolving emulsions produced in preparation of pharmaceuticals by fermentation and in other such bioprocesses is disclosed. The method comprises adding an effective amount of a...
4980284 Method of preparing D-α-amino acids  
A substantial elevation of the space-time yield is achieved in the preparation of D-α-amino acids by means of the biotransformation of hydantoins which are monosubstituted in the 5-position in an...
4980282 Treatment of corn steep liquor  
A process for the treatment of corn steepwater. The steepwater is incubated for a sufficient time to develop biomass before corn steepwater is fed continuously to the developed biomass at a rate...
4865973 Process for extractive fermentation  
A process for producing a variety of chemical products, e.g., ethanol, by fermentation in which the product is removed from the fermentation medium as it is formed by liquid-liquid extraction using...
4847200 Biosynthesis of unnatural cephalosporins  
A process for producing unnatural penicillins and cephalosporin derivatives thereof in which peptide analogs of ACV in which the L-α-aminodipyl moiety is replaced by L-S-carboxymethyl cysteine or...
4769325 2-(Allenyl)penicillins  
2-(Allenyl)penicillins antibiotics and intermediates thereto are disclosed. A process for making the 2-(allenyl)penicillins and the starting materials for the process are also disclosed.
4732851 Immobilization of cells with a polyazetidine prepolymer  
A composition comprising immobilized cells obtained by applying a dispersion of cells and curable prepolymer material selected from the group consisting of polyazetidine prepolymers, carboxymethyl...
Matches 1 - 50 out of 93 1 2 >