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7622299 |
Bioengineered tissue substitutes
In one aspect, the invention provides methods for forming a target tissue substitute. The methods of the invention comprise the following steps: (a) providing a scaffold comprising one or more...
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7608455 |
Modified reconstituted basement membrane composition for assay system
A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin,...
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7595194 |
Isolation of mammalian CNS glial-restricted precursor cells
Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of...
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7579179 |
Cell growth surface on a polymeric substrate
A product exhibiting an improved cell growth surface and cell attachment. According to the present invention, a stream of plasma is comprised of activated gaseous species generated by a microwave...
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7569385 |
Multipotent amniotic fetal stem cells
A source of multipotent amniotic fluid/fetal stem cells (MAFSCs) is disclosed. MAFSC are of fetal origin and have a normal diploid karyotype. These cells are characterized by the following cell...
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7544510 |
Stem cells of the islets of Langerhans and their use in treating diabetes mellitus
Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation...
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7534610 |
3D tissue constructs on the basis of colloidal crystals surface modified by sequential layering
A cell growth matrix for optimizing 3D organization nutrient delivery, controlling release of differentiation factors and facilitating attachment of cells to a scaffold Colloidal crystals and...
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7501280 |
Immobilized cells and liposomes and method of immobilizing the same
In an inexpensive and convenient method for immobilizing a suspension cell, a phospholipid vesicle or the like regardless of the type of cell, on the surface of a solid phase, a cell is immobilized...
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7452720 |
Apparatus for preparing a biocompatible matrix
An apparatus and method of using the apparatus to prepare a biocompatible biodegradable matrix capable of supporting cells to form an implantable or engraftable surgical device. A matrix-forming...
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7435593 |
Hybrid bio actuator and method of manufacturing the same using 3-dimensional micro molding aligner
A hybrid bio actuator and a manufacturing method thereof using a 3-dimensional micro molding aligning apparatus are provided. The manufacturing method has the steps of: 3-dimensionally forming an...
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7422900 |
System and method for forming a connective tissue construct
A system and method are provided for forming a connective tissue construct, such as a tendon construct, in vitro. A substrate is provided with at least two anchors secured thereto in spaced...
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7410791 |
Device containing cytophilic islands that adhere cells separated by cytophobic regions
The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic...
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7396682 |
Method for cell adhesion and wound healing
The present invention relates to a method for cell adhesion and wound healing with internal domains of βig-h3. Particularly, the present invention relates to the method of using recombinant...
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7393687 |
Biomimetic 3-dimensional scaffold with metabolic stream separation for bioartificial liver device
A bio-artificial organ comprises a substrate comprising a roll of a substrate material, and a plurality of cells adhered to the substrate, the roll being formed from a sheet rolled to form a...
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7354764 |
Method and device for culturing cells
In a method for culturing cells ( 2 ), according to which cells ( 2 ) are introduced into a cell culture chamber in order to form a cellular layer, the chamber being configured inside a carrier...
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7323445 |
Methods and compositions for healing and repair of articular cartilage
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The...
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7252973 |
Protein and processes for producing the same
A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a...
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7211657 |
Nucleic acids encoding sialyltransferases from C. jejuni
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a...
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7193038 |
Extraction and utilization of cell growth-promoting peptides from silk protein
Peptides are provided having an excellent safety, stability due to relatively low molecular weights thereof, and cell growth promotion, which are different from cell growth factors produced by...
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7192756 |
Sialyltransferases from C. jejuni
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a...
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7157275 |
Peptides for enhanced cell attachment and growth
The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion...
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7157234 |
Detection of very low quantities of analyte bound to a solid phase
A microscale binding assay, analyte binding array, and kits are disclosed, which exploit the mass action law to harvest analyte from a liquid sample. This is achieved by fabrication of sorbent...
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7115419 |
Process for producing a film for controlling the chemotactic function and an artificial material and process for producing the artificial material
A process for producing a film for controlling the chemotactic function in an extremely small area in which a chemotactic factor substance in the area has a concentration gradient in one direction....
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7115418 |
Methods of proliferating undifferentiated neural cells
The invention discloses methods of proliferation and differentiation of multipotent neural stem cells. Also provided are methods of making cDNA libraries and methods of screening biological agents...
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7101995 |
Compositions and processes using siRNA, amphipathic compounds and polycations
Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal...
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7101546 |
In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be matured in situ into a stable cell line that produces insulin in...
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7074615 |
Peptides for enhanced cell attachment and cell growth
The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion...
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7074612 |
Insect cell primary culture medium, extracellular matrix, and process of preparing an insect culture cell line in a short period of time using the medium and matrix
A novel cell culture medium suitable for primary culture of insect cells, an insect-derived water-soluble chitin, and a process of preparing an insect culture cell line in a short period of time by...
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7067316 |
Methods and devices for the long-term culture of hematopoietic progenitor cells
The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods...
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7067306 |
Device containing cytophilic islands that adhere cells separated by cytophobic regions
The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic...
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7063829 |
Wasp family protein fragments, and use thereof
The invention concerns peptide fragments of the WASP family proteins, or peptides derived from said fragments, and their uses in particular for preparing reagents for use in implementing a method...
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7045363 |
Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide
A nucleic acid-bound polypeptide produced by binding a nucleic acid to a polypeptide, a method of producing the nucleic acid-bound polypeptide, and applications of the nucleic acid-bound...
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7022522 |
Macroporous polymer scaffold containing calcium phosphate particles
A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a...
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7015038 |
Method and apparatus for preparing and culturing cells
A method and an apparatus for preparing and culturing cells, particularly bone marrow stromal cells. The method includes the steps of placing an oxygenator and a scaffold in a container, such as a...
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7008634 |
Cell growth substrates with tethered cell growth effector molecules
Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and...
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6986735 |
Method of making a bioremodelable vascular graft prosthesis
The invention is directed to methods of making bioremodelable graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention...
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6967101 |
Surface and its manufacture and uses
A method for rendering a surface covered by a plastic material more hydrophilic by treatment with a gas plasma non-polymerizable gas. The method is characterized in that the intensity of the plasma...
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6967100 |
Pancreatic islet cell growth factors
The present invention relates generally to growth factors and more particularly to growth factors which are capable of stimulating or otherwise facilitating formation of insulin-secreting cells....
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6964869 |
Method and composition for skin grafts
A chimeric skin comprising immortalized human keratinocyte cells cocultured with donor keratinocytes is disclosed.
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6962814 |
Decellularized tissue engineered constructs and tissues
New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a...
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6960427 |
Process for producing a vascularized bioartificial tissue and an experimental reactor for carrying out the process
The invention concerns a process for producing a three-dimensional bioartificial tissue having viable cells in or on a matrix, and by which cells and matrix can be cultivated into a tissue or a...
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6942873 |
Microfabrication of membranes containing projections and grooves for growing cells
The present invention provides a novel substrate for use in growing cells and for the study of mechanobiology. The membrane of the present invention comprises appropriate microtopography and...
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6913762 |
Stent having non-woven framework containing cells
Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.
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6908736 |
DNA sequencing method
The present invention pertains to a method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and...
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6875442 |
Process for growing tissue in a biocompatible macroporous polymer scaffold and products therefrom
A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a...
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6867040 |
Bioreactor and methods for producing synchronous cells
Apparatus and methods are directed to a perfusion culture system in which a rotating bioreactor is used to grow cells in a liquid culture medium, while these cells are attached to an...
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6858146 |
Artificial liver apparatus and method
Artificial liver devices and methods for using the devices to purify a biological fluid are disclosed. The methods include the use of living hepatocytes ( 23 ) which are either unattached or...
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6852537 |
Transgenic circulating endothelial cells
A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected...
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6844187 |
Bioreactor
The invention relates to a bioreactor as well as a method for cultivating organic material: in particular cells, by means of a nutrient medium. For an intensive cultivation of the organic material...
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6821107 |
Method of forming a structure having multiple cell layers
Multiple cell layers are formed with one cell layer formed on another cell layer. A carrier is provided having an alginate gel layer formed on a porous membrane. An extracellular matrix component...
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