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7632652 |
Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences
The invention is directed to novel compositions of matter and methods of detecting in situ an immunohistochemical epitope or nucleic acid sequence of interest in a biological sample comprising...
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7622276 |
Methods for processing biological tissue
A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating...
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7618828 |
Method for histoprocessing
The invention relates to the processing of a biological sample for histological analysis. In particular, it relates to a rapid automated processing system that can be operated with continuous...
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7618809 |
Microarrayer with coaxial multiple punches
A microarrayer apparatus for constructing arrays of biological material from donor cores obtained from at least one donor block and placing the donor cores in an embedding medium carried by at...
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7593787 |
Systems and methods for the automated pre-treatment and processing of biological samples
Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus are provided. In some embodiments, the...
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7588890 |
Device for extracting biological molecules from tissue specimens and methods for preparing the same
The present invention provides a non-destructive macromolecules extraction (NDME) device for extracting high quantity of biological molecules (including, but not limited to, proteins, DNA, and/or...
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7584019 |
Systems and methods for the automated pre-treatment and processing of biological samples
Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a...
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7569675 |
High affinity monoclonal antibody for recognizing the progesterone receptor (PR) and method for creating the antibody
A lagomorph derived monoclonal antibody for recognizing the progesterone receptor (PR) (clone SP2) with immunohistochemistry and methods for creating such an antibody are disclosed. No need of...
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7569246 |
Method for preparing a biological material for examination under a microscope, and corresponding arrangement comprising a biological material prepared using said method
The invention relates to a method for preparing a biological material for examination with a microscope, comprising the steps of: applying a UV laser light absorbing transparent film onto a surface...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7550298 |
Automated immunohistochemical and in situ hybridization assay formulations
Provided herein are reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for...
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7547542 |
Arrangement and method for a cassette for preparation of biological specimens
A method and an arrangement for preparing a biological specimen ( 20 ), where the biological specimen ( 20 ), prior to being examined in e.g. a microscope, is dried, embedded in wax and optionally...
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7541161 |
Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins
A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes...
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7517648 |
NPHP nucleic acids and proteins
The present invention relates to Nephronophthisis, in particular to the NPHP5 protein (nephrocystin-5) and nucleic acids encoding the NPHP5 protein. The present invention also provides assays for...
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7517663 |
Rabbit monoclonal antibody against Id1 protein
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
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7491541 |
Method for quantitation of collagen in tissue
For successful wound healing to occur, the newly formed skin must generate tensile strength through collagen deposition. Measurement of collagen in the granulating wound bed may be predictive of...
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7449307 |
Raised surface assay plate
The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving...
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7449306 |
Systems and methods for screening pharmaceutical chemicals
A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response...
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7429466 |
Methods and arrays for detecting biological molecules
Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a...
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7405056 |
Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a...
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7374907 |
System and method for automatically processing tissue samples
An apparatus and method for producing tissue slides is disclosed. The apparatus includes a holding assembly for manipulating the sample block, a blade assembly for preparing a thin section from the...
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7358063 |
Method of detecting PS2V
A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a...
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7354729 |
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to...
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7354730 |
High-throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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7297500 |
Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products
Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample....
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7267947 |
Array-based detection of genetic alterations associated with disease
The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal...
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RE39760 |
Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/humans chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens...
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7238488 |
Therapeutic and diagnostic applications of perlecan domain I splice variants
A method of producing antibodies comprising the step of encoding a peptide sequence from a Domain I perlecan splice variant, wherein the peptide sequence is used to produce anti-peptide antibodies.
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7195885 |
Hepatitis C virus assays
The present invention includes an assay useful for identifying inhibitors of Hepatitis C virus (HCV) activity. Particularly, the present invention is directed to a dual HCV assay useful for high...
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7172739 |
Protein fractionation
A method and apparatus for physically separating polypeptide constituents of a sample fluid by (a) providing a sample fluid comprising a mixture of polypeptides of differing physical and/or...
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7156814 |
Apparatus and method for harvesting and handling tissue samples for biopsy analysis
A sectional cassette ( 10 ) for use in a process for harvesting and handling tissue samples for biopsy analysis is disclosed. In the procedure, a tissue biopsy sample is placed on a tissue trapping...
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7148332 |
High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody
High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER...
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7128903 |
Pharmaceutical preparations useful for treating tumors and lesions of the skin and the mucous membranes and methods and kits using same
A pharmaceutical preparation useful for treating a skin or mucous membrane lesion is provided. The pharmaceutical preparation including, as active ingredients, a therapeutically effective amount of...
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7122322 |
Endometriosis-specific secretory protein
A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the...
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7118853 |
Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile...
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7115386 |
Device and method for carrying out immunological marking techniques for thin-sectioned tissue
The invention relates to a device and a method for carrying out in an optimized and automated manner immunological marking techniques for thin-sectioned tissue ( 2 b ). A support plate ( 1 ) which...
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7090974 |
Ultrasound-mediated high-speed biological reaction and tissue processing
Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1–50 MHz is used...
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7074903 |
Monoclonal antibody specific to tartrate-resistant acid phosphatase 5b and use thereof
Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to...
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7070950 |
Recipient block and method for preparation thereof
Disclosed is a recipient block for arraying a certain tissue sample into a desired position on a tissue microarray slide, comprising(a) an additive and (b) a wax. The present invention also...
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7070951 |
Dewaxing kit for immunostaining tissue specimens
Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved...
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7067325 |
Removal of embedding media from biological samples and cell conditioning on automated staining instruments
The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical...
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7005110 |
Method and apparatus for preparing tissue samples for sectioning
The present invention provides a more efficient and faster way to prepare tissue samples for sectioning. More particularly, in accordance with the present invention, a tissue sample is embedded in...
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6992760 |
Apparatus and method for imaging a histological sample
A method of imaging a histological sample is provided which comprises stimulating autofluorescence in a sample using electromagnetic radiation of wavelength 750 nm. Detection of the...
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6969614 |
Methods for the isolation and analysis of cellular protein content
The present invention describes devices and methods for performing protein analysis on laser capture microdissected cells, which permits proteomic analysis on cells of different populations....
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6962789 |
Method for quantitating a protein by image analysis
The present invention provides a method for determining expression levels of one or a multiplicity of target proteins in a tissue or cell sample.
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6960450 |
Antigen activating method and antigen activator
An object of the present invention is to provide a reagent for activating and unmasking antigens in a immuno-tissue-chemical staining. A slice of tissue cells on a slide glass is heated or heated...
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6955924 |
Laminin chains: diagnostic uses
The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto.
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6939716 |
Method for detecting conditions indicative of sepsis
The disclosure describes a method for detecting conditions indicative of sepsis. In one embodiment of the invention, an increase in the level of 3-chlorotyrosine or 3-bromotyrosine from the normal...
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6929927 |
Method of evaluating antifungal agent
A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered...
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6921634 |
Replication competent hepatitus C virus and methods of use
The present invention provides a replication competent hepatitis C virus that includes a heterologous polynucleotide. The invention also includes methods for modifying a hepatitis C virus...
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