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8158381 |
Methods for integrated tissue processing and staining
Methods that combine processing and staining of tissue samples such that the processed tissue is stained and ready for histological evaluation prior to embedding and sectioning, and separate...
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8118962 |
Method and apparatus for spacing cellular matter in a cell block
Methods and apparatus for bonding block of paraffin having cellular material embedded at one end thereof with an additional amount of paraffin are disclosed, including a method comprising placing...
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8093010 |
Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these...
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8093012 |
Multiplex in situ immunohistochemical analysis
A method of in situ immunohistochemical analysis of a biological sample is provided. The method allows for the multiplex and simultaneous detection of multiple antigens, including multiple nuclear...
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8071323 |
Human monoclonal antibodies that bind human insulin like growth factors and their use
Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided.
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8062861 |
Tissue sample preprocessing methods and devices
To preprocess a tissue sample, a first permeable mesh membrane is tautly stretched out over the tissue sample and overlaid on top of a flat surface. This covering sandwiches and secures the tissue...
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8058022 |
Diagnosis and monitoring of mycobacterium tuberculosis infection
Disclosed are methods for detecting protein complexes of sigma factors and interacting proteins in a sample containing Mycobacterium tuberculosis. Such methods are useful for the diagnosis and/or...
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8048640 |
Methods for evaluating and implementing prostate disease treatments
Provide is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia (BPH) and androgen dependent and androgen independent prostate...
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8039226 |
Anti NC1 monoclonal antibody
The present invention dedicates to detect nephritis in early stage of either primary or secondary nephritis using an anti NC1 monoclonal antibody. The present invention dedicates to provide useful...
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8039262 |
Method for controlling a tissue processor and tissue processor
A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided including a cover that can be opened and closed by an operator....
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7993927 |
Histology methods
Described are methods of visualizing biological samples using histological staining and invisible light (e.g., infrared or near-infrared) fluorescence.
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7989178 |
Colony assay miniaturization with enumeration output
A system combining a clonogenic differentiation assay with an instrument-based ATP bioluminescence proliferation assay to produce a standardized colony-forming stem and progenitor cell potency...
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7977092 |
Methods for identifying candidate anti-tumorigenic agents
Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions,...
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7966091 |
Automatic thin-section slides manufacturing system and method
Thin-section slide samples are manufactured from respective embedding blocks containing a biological sample and held in an embedding cassette having imprinted thereon individual data. The embedding...
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7927564 |
Histological specimen cassette
A histological specimen cassette for use in connection with a larger histological specimen cassette, wherein each histological specimen cassette has an internal chamber that includes a receptacle...
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7914738 |
Cell block cassette and filter assembly
A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly...
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7907259 |
Laser microdissection method, control system for a laser microdissection device and carrier device
A microdissection method for separating and taking a target zone of a biological preparation, disposed on a carrier device with a laser light-absorbent incisable layer and a carrier means,...
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7892770 |
Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a)...
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7883861 |
High throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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7863006 |
Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies
This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an...
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7858039 |
Tissue piece treating apparatus
Provided is a tissue piece treating apparatus comprising an automatic controlling means for feeding back the temperature of the treatment liquid or molten paraffin in the bath inside detected by a...
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7842500 |
Anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate
An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine...
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7767414 |
Optical imaging of molecular characteristics of biological specimen
Imaging specimen such as biological tissue is facilitated. According to an example embodiment of the present invention, a relatively thin, surface portion of a specimen is stained and imaged. The...
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7741052 |
Method of assessing the risk of atherosclerosis
A method for aiding in the determination of whether a living or deceased human is afflicted with or will likely have atherosclerosis respectfully, the method comprising determining the level of...
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7727760 |
Cell colonies dissecting and transplanting apparatus
A cell colonies dissecting and transplanting apparatus comprises: a base, a platform, a feeding mechanism having at least three axis feeding means, a movable holder, a cutting means, a...
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7727481 |
Specimen holder having an insert for atomic force microscopy
A specimen holder (10) is proposed in order to create a capability for preparing, in a cutting device, in particular a microtome or ultramicrotome, a specimen that is to examined in an AFM. The...
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7713743 |
Method for quantitation of collagen in tissue
For successful wound healing to occur, the newly formed skin must generate tensile strength through collagen deposition. Measurement of collagen in the granulating wound bed may be predictive of...
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7682799 |
Cell division marker
This application relates to a newly identified animal cell structure, the midbody scar. This structure is a remnant of the midbody that is retained by one daughter cell following cytokinesis and...
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7666615 |
High-throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to assays, methods, and kits that provide reagent mixes and instructions for determining the proliferative status of isolated target cell populations. The...
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7622276 |
Methods for processing biological tissue
A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating...
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7618828 |
Method for histoprocessing
The invention relates to the processing of a biological sample for histological analysis. In particular, it relates to a rapid automated processing system that can be operated with continuous...
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7618809 |
Microarrayer with coaxial multiple punches
A microarrayer apparatus for constructing arrays of biological material from donor cores obtained from at least one donor block and placing the donor cores in an embedding medium carried by at...
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7588890 |
Device for extracting biological molecules from tissue specimens and methods for preparing the same
The present invention provides a non-destructive macromolecules extraction (NDME) device for extracting high quantity of biological molecules (including, but not limited to, proteins, DNA, and/or...
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7569246 |
Method for preparing a biological material for examination under a microscope, and corresponding arrangement comprising a biological material prepared using said method
The invention relates to a method for preparing a biological material for examination with a microscope, comprising the steps of: applying a UV laser light absorbing transparent film onto a surface...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7550298 |
Automated immunohistochemical and in situ hybridization assay formulations
Provided herein are reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for...
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7547542 |
Arrangement and method for a cassette for preparation of biological specimens
A method and an arrangement for preparing a biological specimen (20), where the biological specimen (20), prior to being examined in e.g. a microscope, is dried, embedded in wax and optionally...
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7541161 |
Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins
A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes...
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7517648 |
NPHP nucleic acids and proteins
The present invention relates to Nephronophthisis, in particular to the NPHP5 protein (nephrocystin-5) and nucleic acids encoding the NPHP5 protein. The present invention also provides assays for...
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7517663 |
Rabbit monoclonal antibody against Id1 protein
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
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7491541 |
Method for quantitation of collagen in tissue
For successful wound healing to occur, the newly formed skin must generate tensile strength through collagen deposition. Measurement of collagen in the granulating wound bed may be predictive of...
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7449307 |
Raised surface assay plate
The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving...
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7449306 |
Systems and methods for screening pharmaceutical chemicals
A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response...
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7429466 |
Methods and arrays for detecting biological molecules
Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a...
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7405056 |
Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a...
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7374907 |
System and method for automatically processing tissue samples
An apparatus and method for producing tissue slides is disclosed. The apparatus includes a holding assembly for manipulating the sample block, a blade assembly for preparing a thin section from the...
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7358063 |
Method of detecting PS2V
A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a...
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7354729 |
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to...
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7297500 |
Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products
Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample....
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7267947 |
Array-based detection of genetic alterations associated with disease
The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal...
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