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7632652 |
Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences
The invention is directed to novel compositions of matter and methods of detecting in situ an immunohistochemical epitope or nucleic acid sequence of interest in a biological sample comprising...
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7622276 |
Methods for processing biological tissue
A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating...
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7618792 |
Multiplexed detection of anti-red cell alloantibodies
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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7618784 |
Assay for phospholipid transfer protein (PLTP) activity
Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the...
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7615355 |
Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration
The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for...
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7611863 |
Selective staining of biomembranes using voltage-sensitive dyes
The present invention relates to a method for staining membranes, in particular, a method for selective staining of cells using voltage-sensitive dyes.
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7598046 |
Use of prion conversion modulating agents
The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically,...
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7593787 |
Systems and methods for the automated pre-treatment and processing of biological samples
Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus are provided. In some embodiments, the...
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7592150 |
Method for diagnosing diseases based on levels of anti-glycan antibodies
Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample.
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7584019 |
Systems and methods for the automated pre-treatment and processing of biological samples
Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a...
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7579454 |
Method for detecting gram-positive bacteria
The present invention relates to a method for detecting and/or identifying Gram-positive bacteria with high GC content, in particular mycobacteria. The method comprises a nucleic acid amplification...
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7569812 |
Remote reagent ion generator
An improved ion source and means for collecting and focusing dispersed gas-phase ions from a remote reagent chemical ionization source (R2CIS) at atmospheric or intermediate pressure is described....
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7569339 |
Use of flow-cytrometric analysis to optimize cell banking strategies for CHO cells
Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation...
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7569246 |
Method for preparing a biological material for examination under a microscope, and corresponding arrangement comprising a biological material prepared using said method
The invention relates to a method for preparing a biological material for examination with a microscope, comprising the steps of: applying a UV laser light absorbing transparent film onto a surface...
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7563591 |
Method for assaying the activity of lysosomal enzymes
A method, and associated kit, for assaying the activity of lysosomal enzymes present in dried bodily fluids and cell tissue samples, such as α-L-iduronidase, β-D-galactosidase, β-D-glucosidase,...
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7560243 |
White blood cell functional assay
A method of rapidly assaying nucleotide receptor P2X 7 pore activity in white blood cells contained within a blood sample. A method according to the invention includes the steps of: (a) labeling...
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7550298 |
Automated immunohistochemical and in situ hybridization assay formulations
Provided herein are reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for...
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7541161 |
Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins
A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes...
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7521187 |
Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
This invention relates generally to the freeze-drying of formulations comprising a polynucleotide, a block copolymer and a cationic surfactant. In the presence of a cryoprotectant or bulking agent,...
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7521250 |
Fluorescent sensor for phosphate ion and phosphorylated peptide
Disclosed is a fluorescent sensor for phosphate ion and phosphorylated peptide, which comprises a phosphate anion-selective fluorescent compound expressed by the following general formula (1). In...
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7507548 |
Multidimensional detection of aberrant phenotypes in neoplastic cells to be used to monitor minimal disease levels using flow cytometry measurements
A method for detecting aberrant phenotypes expressed by neoplastic cells includes the steps of: 1) staining one or more normal/reactive samples and one neoplastic sample with multiple combinations...
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7476510 |
Miniaturized cell array methods and apparatus for cell-based screening
Methods and cassettes for cell-based toxin detection and organ localization are disclosed. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each...
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7476511 |
Method of detecting and analyzing paclitaxel-mimetic compounds
A large part of cytostatics, among them paclitaxel (Taxol®) and other recently discovered substances that mimic its antitumour effects, have cellular microtubules as their target. The present...
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7473532 |
Liquid tissue preparation from histopathologically processed biological samples, tissues and cells
The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for...
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7456938 |
Laser microdissection on inverted polymer films
Systems and methods for automated laser microdissection are disclosed. A sample of biological material is located between a polymer membrane and a substrate. Targeted biological material is...
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7452506 |
Automated staining and decolorization of biological material
An improved method and apparatus for staining samples of biological material for accurate analysis of the sample. Biological material is applied to a substrate, such as a microscope slide. The...
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7452727 |
Method for increasing clinical specificity when detecting tumors and their precursor stages by simultaneously measuring at least two different molecular markers
The present invention relates to an automatable method for the improved diagnosis of pathologically altered cells by simultaneously staining at least two different molecular markers, which exhibit...
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7449306 |
Systems and methods for screening pharmaceutical chemicals
A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response...
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7445897 |
Sequence variants of multi-drug resistance genes, MDR1 and MRP1, and methods for assessment of drug penetration and disposition
Provided are compositions relating to novel MDR1 polymorphisms, including nucleic acids, polypeptides, and recombinant cells, as well as methods for detection of MDR1 polymorphisms in biological...
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7445910 |
Method for enumerating mammalian cell micronuclei with an emphasis on differentially staining micronuclei and the chromatin of dead and dying cells
The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes...
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7435383 |
Automated tissue staining system and reagent container
An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a...
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7429466 |
Methods and arrays for detecting biological molecules
Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a...
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7429465 |
Process for analyzing tear fluid
The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of
(a) physically or chemically inducing a volume...
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7427502 |
Methods for identifying stem cells based on nuclear morphotypes
Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions,...
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7425427 |
Method for staining corneocytes, method for preparing corneocytes specimen and skin analysis system
A method for preparing corneocytes specimen, which comprises stripping off corneocytes from the surface of a skin using an adhesive material, staining the corneocytes in a solution of stain in...
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7413872 |
Device for preparing specimens for a cryo-electron microscope
The invention relates to a device for preparing specimens for a cryo-electron microscope, comprising an environmental chamber, a holder for a sample or a carrier, and at least one blotting element...
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7405056 |
Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a...
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7405072 |
Acoustic radiation for ejecting and monitoring pathogenic fluids
The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a...
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7390630 |
Method of identifying a compound that selectively inhibits cytokine-stimulated T cell induced production of TNF-alpha by monocytes
A method of identifying a compound with efficacy in the treatment of chronic inflammatory disease by testing the compound for an ability to selectively inhibit the ability of T ck cells to induce...
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7384764 |
Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine
Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the...
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7371518 |
Universal collection medium
This invention provides a novel universal collection medium for cell collection. The medium allows for the first time the ability to perform cytology and direct molecular analysis on cells...
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7368253 |
Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies
Markers for TSE that are present prior to formation of detectable pathological prion protein are useful to detect this infection prior to clinical signs. Additional markers are useful to detect the...
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7368132 |
Glyoxal/zinc fixative
This invention provides compositions and methods for fixing a biological sample, particularly fecal samples for diagnosis of parasitic infection. The fixative composition of the present invention...
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7364868 |
Krüppel-like transcriptional factor KLF4/GKLF and uses thereof
The present invention proivdes methods of identifying new carcinoma oncogenes or analyzing functions of known carcinoma oncogenes by transformation of RK3E cells. Also provided are methods of using...
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7361462 |
Method for efficiently determining a DNA strand break
The present invention is directed to directly measure distribution in vivo and the frequency of generation in vivo of DNA strand breaks which induce cell death and mutations. The present inventors...
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7354773 |
Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry
A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such...
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7344842 |
Prion test
The invention is related to diagnostic methods for detecting transmissible spongiform encephalopathies (TSEs) such as BSE and scrapie and related disease in humans. The invention provides use of...
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7332295 |
Multidimensional leukocyte differential analysis
This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells,...
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7332340 |
Process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis
The present invention relates to a process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis comprising testing M....
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7326577 |
Cell fixation and use in phospho-proteome screening
A new method of cell fixation using a mild denaturing heat and the fixative PERMIFLOW™ or similar fixative that preserves cell morphology, light scatter profiles, nucleic acid content, cell...
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