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8183375 |
Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength...
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8175369 |
Multi-nucleated cell classification and micronuclei scoring
Methods and systems for counting nuclei for cells in a cell-containing sample are disclosed, such as carried out on a computer. The methods comprise: receiving a raw image of the cell-containing...
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8158381 |
Methods for integrated tissue processing and staining
Methods that combine processing and staining of tissue samples such that the processed tissue is stained and ready for histological evaluation prior to embedding and sectioning, and separate...
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8158380 |
Imaging agents for protein misfolding
Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using...
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8153364 |
Emulsion compositions
An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a...
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8148081 |
Method for detecting microorganisms on a membrane
The present invention relates to a method using a composition for permeabilizing microorganism walls for counting and detecting in a targeted manner the microorganisms on a membrane. The invention...
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8129532 |
Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use
Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit...
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8118962 |
Method and apparatus for spacing cellular matter in a cell block
Methods and apparatus for bonding block of paraffin having cellular material embedded at one end thereof with an additional amount of paraffin are disclosed, including a method comprising placing...
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8114625 |
Method for cell analysis
The invention describes a method for cell analysis in which the cells to be analyzed are adhesively applied to a slide and stained with a first stain. A first digital image is then taken and stored...
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8114606 |
ARL-1 specific antibodies
This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides...
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8093010 |
Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these...
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8093012 |
Multiplex in situ immunohistochemical analysis
A method of in situ immunohistochemical analysis of a biological sample is provided. The method allows for the multiplex and simultaneous detection of multiple antigens, including multiple nuclear...
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8092758 |
Method, device and system for volumetric enumeration of white blood cells
A sample acquiring device for volumetric enumeration of white blood cells in a blood sample comprises a measurement cavity for receiving a blood sample. The measurement cavity has a predetermined...
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8058022 |
Diagnosis and monitoring of mycobacterium tuberculosis infection
Disclosed are methods for detecting protein complexes of sigma factors and interacting proteins in a sample containing Mycobacterium tuberculosis. Such methods are useful for the diagnosis and/or...
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8048640 |
Methods for evaluating and implementing prostate disease treatments
Provide is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia (BPH) and androgen dependent and androgen independent prostate...
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8048669 |
Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins
A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes...
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8048644 |
Biological indicator for monitoring the transport of micro-organisms in the environment
A method of using a biological indicator to detect and identify sources of fecal contamination such as leaking sewer lines, septic tanks, and holding lagoons, using a microorganism having a...
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8039226 |
Anti NC1 monoclonal antibody
The present invention dedicates to detect nephritis in early stage of either primary or secondary nephritis using an anti NC1 monoclonal antibody. The present invention dedicates to provide useful...
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8039262 |
Method for controlling a tissue processor and tissue processor
A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided including a cover that can be opened and closed by an operator....
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8034625 |
Animal cell colony picking apparatus and method
An apparatus and method for automated picking of animal cell colonies is described. A picking head comprising a plurality of hollow pins is provided. The apparatus has an integrated imager for...
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7998700 |
Use of a composition which regulates oxidation/reduction reactions intracellularly and/or extracellulary in a staining or sorting process
Staining mixtures comprising viable spermatozoa, a composition which regulates oxidation/reduction reactions intracellularly or extracellularly, and a DNA selective dye are disclosed. The cells...
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7993927 |
Histology methods
Described are methods of visualizing biological samples using histological staining and invisible light (e.g., infrared or near-infrared) fluorescence.
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7989157 |
Solution for storing bioprosthetic tissue used in a biological prosthesis
A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating...
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7977092 |
Methods for identifying candidate anti-tumorigenic agents
Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions,...
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7960138 |
Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine
Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the...
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7960131 |
Functional genomic pore assay for mixed cell populations
A method of assaying nucleotide receptor P2X7 pore activity in white blood cells contained within a mixed cell sample is provided comprising labeling white blood cells with a white blood...
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7958791 |
Cryogenic storage device comprising a transponder
A method for operating a cryostorage device (100), especially for biological samples, is described which comprises a sample carrier (10) to receive at least one sample (11) and a data storage (20),...
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7955867 |
High throughput cell-based assays, methods of use and kits
In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation....
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7951345 |
Useful specimen transport apparatus with integral capability to allow three dimensional x-ray images
The present invention provides new and useful features and mechanisms for the localization and transport of biopsy specimens. The invention having a specimen board, an absorbent material in...
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7951612 |
In situ heat induced antigen recovery and staining apparatus and method
Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction...
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7947464 |
Method for identifying regulatory T cells
The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases,...
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7927830 |
Modified carbocyanine dyes and their conjugates
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described....
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7923679 |
Method and device for handling objects
In relation with a laser-induced transport process of an object from a carrier to a collecting device, the invention provides a collecting medium in the collecting device in a liquid state. Prior...
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7919436 |
Sequences for differential diagnostic of Ehrlichia ruminantium and use thereof
The invention provides genes that are unique either to Ehrlichia ruminantium strain Gardel or to Ehrlichia ruminantium strain Welgevonden, or allelic couples which are present in both strains but...
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7914462 |
Methods for processing cell block
A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly...
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7914738 |
Cell block cassette and filter assembly
A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly...
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7915007 |
Fixative for fixing biological materials
A fixative for fixing biological materials contains a depot agent, preferably a polyamine and especially hexamethylenetetramine, which reacts chemically with positively charged ions, especially H+...
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7901941 |
Automated tissue staining system and reagent container
An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a...
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7892770 |
Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a)...
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7888132 |
Method for processing tissue samples in preparation for histological examination
A histological specimen retaining device for processing tissue. The histological specimen retaining device comprises a foldable permeable sheet having edges and a permeable target disposed on the...
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7888053 |
Making encoded ghost cells for multiplexed detection of anti-red cell alloantibodies
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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7888136 |
Unsymmetrical cyanine dimer compounds and their application
Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two...
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7883864 |
Method of treating biological tissue by microwave-irradiation
A method of efficiently removing or fixing donor cells from a native tissue of mammalian origin comprises immersing the tissue in a treating solution, and irradiating the tissue with microwave...
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7871791 |
Biofilm preparation using potassium permanganate
A method for preparing a biofilm includes the steps of rinsing the biofilm. There is the step of staining the biofilm with potassium permanganate and water.
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7867704 |
Mycobacterial diagnostics
The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules...
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7863006 |
Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies
This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an...
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7842500 |
Anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate
An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine...
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7820393 |
Methods, kits and antibodies for detecting parathyroid hormone
The present invention relates to novel methods and compositions useful for detecting whole parathyroid hormone at a physiological level and parathyroid fragments in a mammalian sample. Such...
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7816519 |
Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength...
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7817840 |
Predicting hepatotoxicity using cell based assays
Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the...
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