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7620502 |
Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedure
In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination.
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7618810 |
Metering strip and method for lateral flow assay devices
A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection...
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7618795 |
Starch process
The present invention relates to a process for enzymatic hydrolysis of granular starch into a soluble starch hydrolysate at a temperature below the initial gelatinization temperature of said...
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7618784 |
Assay for phospholipid transfer protein (PLTP) activity
Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the...
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7618783 |
Anthrax specific antibodies
The present invention is directed to diagnostic tools and therapies using antibodies to Bacillus anthracis. Specifically, the present invention is directed to a B. anthracis -specific monoclonal...
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7618772 |
Methods and compositions for diagnosing and suppressing metastasis thereof
Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis...
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7618771 |
Method of combing a nucleic acid
Elongated molecules are stretched across a substrate by controlled fluid flow.
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7618392 |
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solution
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of...
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7615646 |
Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3′-dymethyl-3H-indole and its derivatives as intermediates for...
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7615339 |
Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
The invention provides methods for fabricating calorimetric resonant reflection biosensors.
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7615222 |
Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same
The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is...
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7615218 |
Methods for determining and lowering caffeine concentration in fluids
Single-chain, camelized heavy chain antibodies immunospecific for caffeine and stable at high temperatures are useful for analysis and recovery of caffeine in or from fluids. A device that provides...
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7615207 |
Methods for treating irritable bowel syndrome
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7611863 |
Selective staining of biomembranes using voltage-sensitive dyes
The present invention relates to a method for staining membranes, in particular, a method for selective staining of cells using voltage-sensitive dyes.
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7611862 |
Method and apparatus for detecting and quantifying bacterial spores on a surface
A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: bacterial spores are transferred from a place of origin to a test surface, the...
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7611836 |
Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
Methods of producing liquid handling biosensor devices are provided. The liquid handling biosensor devices allow detection of biomolecular interactions in liquid. The use of labels is not required...
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7611835 |
Process for preparing multilayer enzyme coating on a fiber
A process for preparing high stability, high activity biocatalytic materials is disclosed and processes for using the same. The process involves coating of a material or fiber with enzymes and...
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7611834 |
Methods and devices for protein assays
Methods and devices for protein assays based on Edman degradation in microfluidic channels are disclosed herein. As disclosed, the cleaved amino acid residues may be immobilized in an array format...
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7611833 |
Yeast genes that affect viral replication
An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus...
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7611832 |
Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure
The present invention relates to methods of identifying whether a candidate compound is a modulator of an orphan G protein-coupled receptor (GPCR). Preferably the GPCR is human. In some...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608466 |
Process and device for producing reagent carriers
The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of...
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7608445 |
Nitrilases, nucleic acids encoding them and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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7608419 |
Method and apparatus for detecting and quantifying bacterial spores on a surface
A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: a matrix including lanthanide ions is provided on the surface containing the...
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7608415 |
Analysis of intracellular modifications
Improved methods of determining the intracellular state of a protein as well as modifications of the protein are provided by introducing a surrogate fusion protein comprising a member of an enzyme...
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7608246 |
Apolipoprotein E as an adjuvant for lipid antigens
The present invention is directed to pharmaceutical compositions that contain a combination of apolipoprotein E and an antigenic lipid. The compositions may be administered to a subject for the...
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7608245 |
Methods for manipulating satiety
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7606670 |
Crystal structure of the 30S ribosome and its use
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
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7605280 |
Anthraquinone and its derivatives
There is disclosed a compound of formula (I) wherein each of X 1 and X 2 are independently NH-A-NR 1 R 2 , and wherein A is A C 2-8 alkylene and R 1 and R 2 are independently selected from...
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7605004 |
Test strip for a lateral flow assay for a sample containing whole cells
A test strip for conducting a lateral flow assay for detection of an analyte in a sample that contains cells and fluid is provided, as well as methods for making and using the test strip. This test...
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7605003 |
Use of biomarkers for detecting ovarian cancer
The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the...
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7604969 |
Mutant glucose dehydrogenase
A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having...
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7604953 |
Bioamplification for microbial sensor signal transduction
A process of detection of the causative agent of Johne's disease ( Mycobacterium avium subsp. paratuberculosis ) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of...
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7604950 |
Methods for early detection of pregnancy in cows
Disclosed are methods for determining the pregnancy status of a cow by detecting a pregnancy-associated glycoprotein (PAG) level that comprises proteins present in an acidic protein fraction of day...
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7604934 |
Method of screening candidate compounds for susceptibility to biliary excretion by endogenous transport systems
A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile...
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7604933 |
Method for sorting tumor cells
The present invention relates to a method for storing cells, wherein the cells are stored in a composition comprising a base nutritive medium and liposomes at temperatures in the range of −196°...
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7604932 |
Assay for tissue factor in a sample
The invention provides assays for detecting and quantitating tissue factor and factor VIIa in simple and complex biological systems. The assays are performed by detecting and/or measuring the...
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7604931 |
Cripto mutant and uses thereof
The present invention is based on the discovery that CRIPTO mutants each comprising at least one amino acid substitution from a CRIPTO polypeptide demonstrate tumor blocking activity.
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7604807 |
Use of pullulan to isolate and preserve biological material
Compositions and methods for the reversible preservation of biological samples are provided. The compositions include natural polymers such as pullulan or acacia gum, including derivations and...
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7601805 |
Photoprotein with improved bioluminescence
Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.
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7601684 |
Diagnosis and treatment of disorders of iron metabolism
The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The...
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7601498 |
Methods of using dyes in association with nucleic acid staining or detection and associated technology
Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection...
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7601489 |
Manganese ion regulation of reverse transcriptase activity and methods of modulating same
Methods of identifying agents that modulate reverse transcriptase activity in a cell by affecting manganese ion transport across a membrane of the cell are provided, as are agents identified using...
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7599066 |
Localized plasmon resonance sensor
A localized plasmon resonance sensor for detecting a change in optical constant uses a structure including metal. In a response spectrum with respect to light incident on the structure, there are...
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7598063 |
Process for producing ethanol by using recombinant coryneform bacterium
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
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7598051 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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7598047 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7598042 |
Early prostate cancer antigens (EPCA), polynucleotide sequences encoding them, and their use
A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without...
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7598029 |
Method for identifying HIV-1 protease inhibitors with reduced metabolic affects
The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic...
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7598028 |
Compositions and methods for detecting and treating prostate disorders
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating cellular proliferation disorders and cellular motility disorders. In particular,...
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