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7582460 |
3-phosphoglycerate dehydrogenase variants whose inhibition by L-serine is reduced, and genes encoding them
A 3-phosphoglycerate dehydrogenase (PGD) which exhibits a susceptibility to inhibition by serine which is reduced a as compared with that of an Escherichia coli wild-type PGD and which possesses...
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7582418 |
Antimicrobial chelates
Methods useful for inhibiting growth of a variety of microbes including bacteria and fungi are disclosed. The methods involve contacting a microbe with an inhibitory amount of a zinc chelate....
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7584087 |
Structure of protein kinase C theta
A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
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7582415 |
Rapid detection of replicating cells
The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial...
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7582428 |
Methods and compositions for identifying anti-HCV agents
The invention provides methods and compositions for identifying agents for treating infection by viruses that encode a nucleotide-binding NS4B protein, or functional equivalent thereof, e.g.,...
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7582259 |
Blood analysis device and blood analysis method
A blood analysis device for centrifugally separating plasma in a channel, wherein conveyance of blood, plasma and calibration liquid is effected within the device without using a pump or the like....
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7579454 |
Method for detecting gram-positive bacteria
The present invention relates to a method for detecting and/or identifying Gram-positive bacteria with high GC content, in particular mycobacteria. The method comprises a nucleic acid amplification...
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7579175 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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7579141 |
Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic...
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7579140 |
Method and reagent for measuring nitroreductase enzyme activity
Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays. The dyes are...
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7579160 |
Methods for the detection of cervical cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic...
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7579142 |
Methods for purification of bacterial cells and components
The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
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7575883 |
Cytochrome c acetylation
Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
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7575877 |
Method of diagnosing tuberculosis
The present invention relates to a method of diagnosing tuberculosis in a subject, said method comprising steps of: detecting anti- Mycobacterium tuberculosis (M.tb.) isocitrate dehydrogenase...
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7575928 |
Genes for diagnosing colorectal cancer
This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of...
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7575857 |
Screening method for identifying protective substances for treating neurodegenerative and/or ischemic disorders
The present invention relates to a screening method for the identification of protective substances which influence haemoglobin formation in neuronal, myocardial and/or skeletomuscular cells, as...
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7575938 |
Method for diagnosing liver diseases
The present invention relates to a method for diagnosing a liver disease rapidly in an early stage. More particularly, the present invention relates to a monoclonal antibody against asialo α1-acid...
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7575858 |
Method of visualizing proteins bound to protein-binding membranes
A method of visualizing proteins bound to a protein-binding membrane is provided herein, comprising reacting proteins bound to protein-binding membranes with a compound of formula (I) wherein R a ,...
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7572616 |
Alternative oxidase and uses thereof
The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX)...
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7572575 |
SIR2 activity
This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53,...
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7572574 |
Method of measuring neprilysin activity
The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve...
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7572597 |
Diagnostics method
Method of diagnosing in an individual recent exposure to an agent which is a pathogen, vaccine or any other moiety which induces a cellular response, said method comprising determining in vitro...
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7569351 |
P53 dependent apoptosis-associated gene and protein
A novel apoptosis-associated gene p53AIPI is isolated by screening for a gene the expression of which is induced by p53. Since the protein encoded by this gene has an activity of inducing...
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7569812 |
Remote reagent ion generator
An improved ion source and means for collecting and focusing dispersed gas-phase ions from a remote reagent chemical ionization source (R2CIS) at atmospheric or intermediate pressure is described....
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7569375 |
Alcohol dehydrogenases with increased solvent and temperature stability
The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber , their preparation, their use in the oxidation of secondary alcohols and/or the...
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7569339 |
Use of flow-cytrometric analysis to optimize cell banking strategies for CHO cells
Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation...
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7569246 |
Method for preparing a biological material for examination under a microscope, and corresponding arrangement comprising a biological material prepared using said method
The invention relates to a method for preparing a biological material for examination with a microscope, comprising the steps of: applying a UV laser light absorbing transparent film onto a surface...
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7569338 |
Diagnostic assays of secreted biological fluids for detection of infection and inflammatory conditions
A rapid and convenient method for detecting inflammatory conditions in breast tissue, such as those associated with mastitis, is described. The method comprises measuring the presence and quantity...
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7566528 |
Method for the identification and/or validation of receptor tyrosine kinase inhibitors
An in vivo method for the identification and/or validation of receptor tyrosine kinase inhibitors is described. Said method is characterized by the following steps: providing host cells comprising...
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7566418 |
Biochemical concentrator and drug discovery
A novel label-free sensitive detection method by employing a novel sensitive charge sensor is provided. Dissociation constant information is provided by a simple measurement of the dissociation of...
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7566559 |
Human cyclin-dependent kinase (hPNQALRE)
A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for...
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7566765 |
Heterocyclic compounds containing a nine-membered carbon-nitrogen ring
The present invention provides heterocyclic compounds having a nine-membered ring of three repeating C—C—N subunits covalently bound to each other through amide bonds, and variable side groups...
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7566544 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7566741 |
Methods of inhibiting osteoclast activity
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the...
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7563609 |
Mutant 2,5-diketo-L-gluconic acid reductases
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
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7563879 |
Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invetion relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also realtes to an isolated nucleic acid encoding the leafhopper ecdysone receptor...
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7561972 |
Synthetic nucleic acids for expression of encoded proteins
A method of designing a polynucleotide sequence encoding a polypeptide sequence of a predetermined polypeptide is provided. A frequency lookup table corresponding to an expression system is...
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7560227 |
Biomarkers of vulnerable atherosclerotic plaques and methods of use
The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular...
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7560226 |
Assay to detect a binding partner
A method can identify a type of leukemia in a human subject. A biological sample from the human subject that contains CD antigens is obtained. The sample is contacted with an array of...
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7560244 |
Method of evaluating a subject for risk or predisposition of reduced renal function over time
The invention includes diagnostic, predictive, prognostic and monitoring methods and reagents for loss of renal function, e.g., diabetic nephropathy and end stage renal disease (ESRD).
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7560246 |
Compositions and methods for detecting target microorganisms in a sample
The present invention relates generally to compositions and methods for detecting target microorganisms in a sample. In particular, the present invention relates to compositions comprising a...
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7560242 |
Metadherin polypeptides, encoding nucleic acids and methods of use
Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the...
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7560556 |
Assay methods using chemiluminescent detection of peroxidase
Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a...
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7561973 |
Methods for determining properties that affect an expression property value of polynucleotides in an expression system
A method of determining a property that affects expression of polynucleotides in an expression system. A plurality of polynucleotides, each encoding a polypeptide sequence, is constructed. An amino...
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7558717 |
Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
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7556805 |
Compositions for treatment of melanoma and method of using same
Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic...
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7553615 |
Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their...
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7553648 |
Cytochrome P450 monooxygenases consisting of thermophilic bacteria
The invention relates to novel cytochrome P450 monooxygenases from thermophilic bacteria, in particular the genus Thermus sp., to nucleotide sequences encoding them, to the recombinant production...
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7553614 |
High sensitivity fluorometric assays
Spectrophotometric assays are rendered more sensitive by adding to the assay mixture a light-emitting moiety. The decrease in intensity of light emitted due to the presence of a light-absorbing...
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7550256 |
Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
Disclosed are methods for detecting multidrug resistance in neoplastic or damaged cells or multidrug resistant (MDR) neoplastic or damaged cells by detecting an increase in the cell surface...
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