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7202069 |
(R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes
This invention provides (R)-2-octanol dehydrogenase that catalyzes oxidation-reduction reaction using NAD + (NADH) as a coenzyme and the genes that encodes them. The enzymes of this invention can...
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7202082 |
Immortalized preosteoblasts and method for their production
The present invention relates to novel immortalized pre-osteoblast cell lines derived from the periost and capable of differentiate to osteoblasts. In particular, the present invention pertains to...
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7202033 |
Identification of kinase inhibitors
The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the...
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7198896 |
Immunoaffinity isolation of modified peptides from complex mixtures
The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism,...
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7198890 |
Method for quantitatively determining homocysteine and a reagent for quantitative determination of homocysteine
The present invention provides a method for quantitatively determining homocysteine in a biological specimen containing homocysteine and cysteine by use of an enzyme which is capable of forming...
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7198933 |
Thermotoga neapolitana xylose isomerase polypeptides and nucleic acids encoding same
The present invention provides novel isolated polynucleotides encoding a novel xylose isomerases capable of catalyzing the conversion of glucose to fructose and nucleic acids encoding for such...
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7200493 |
Method for screening crystallization or amorphous stage conditions for molecules
A system and a method for screening of nucleation tendency of a molecule, such as a macromolecule, based on acoustic, electrostatic or hybrid acoustic/electrostatic levitation of a droplet for...
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7198932 |
Gdp-4-keto-6-deoxy-d-mannose-3,5-epimerase-4-reductase gene derived from arabidopsis thaliana
The present invention relates to a gene for an enzyme involving in the synthesis of GDP-L-fucose. Particularly, the present invention relates to a GDP-4-keto-6-deoxy-D-mannose-3,...
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7197169 |
Method for detecting a response of each probe zone on a test strip
A method for detecting a response (grey level) of each probe zone on a test strip includes providing a test strip having a color pattern. The color pattern occurs in response to a solution...
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7195903 |
Methods for the treatment of thrombosis
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by...
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7195924 |
Method for immobilizing a biomolecule on a solid substrate at a high density by using the substrate having an activated carboxyl group on a surface thereof and microarray produced using the method
Provided is a method for immobilizing a biomolecule on a solid substrate. The method includes coating the solid substrate with silane anhydride to introduce an anhydride functional group onto a...
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7195913 |
Randomly ordered arrays and methods of making and using
Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A...
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7192718 |
Methods for identifying a substance which specifically binds to an osteoclastogenesis inhibitory factor-binding molecule and modulates the biological activity thereof
The present invention relates to a novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a...
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7193051 |
Histidine phosphatase interacting protein with 240kD
PHPIP-240 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PHPIP-240 polypeptides and...
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7192721 |
Universal rapid test and method for detection of tuberculosis in multiple host species
A universal test apparatus for detecting tuberculosis (TB) in any of many different species of non-primate mammals is provided. The universal test apparatus includes a test site having a...
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7192784 |
Method of measurement in chromatography
A substantial amount of a marker reagent associated with a measurement is measured in a marker reagent measurement area, and the substantial amount of the marker reagent is reflected by a result...
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7192697 |
Procedure for anti-Limulus-factors-independent determination of lipopolysaccharide- and/or lipid-A- and/or glucan- reactivity, suitable test system for this as well as its usage
A modified limulus test procedure is provided to measure the lipopolysaccharide (LPS), lipid A, and/or glucan reactivity in a biological liquid. The test procedure is independent of the...
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7189522 |
Dual path immunoassay device
The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the...
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7189503 |
Characterization of individual polymer molecules based on monomer-interface interactions
The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the...
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7189511 |
Methods of screening and diagnostics using ATP-binding cassette transporter
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting...
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7188031 |
Method for acquiring information of a biochip using time of flight secondary ion mass spectrometry and an apparatus for acquiring information for the application thereof
A measurement method is provided, which enables to obtain a two-dimensional image with better quantitative-ability by suppressing the influence of the charge-up, when the two-dimensional secondary...
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7186516 |
Methods of detecting specific cell lysis
The present invention provides methods of detecting specific lysis of a cell by a lytic agent. The methods generally involve contacting a labeled target cell with a lytic agent; and detecting...
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7186502 |
Process for preparing control samples of particles such as microorganisms and cells
Processes for preparing controlled samples of particles, including microorganisms and cells are described. A sample of particles is provided and separated into a predetermined number of desired...
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7186543 |
Preparation of vaccines using a photosensitizer and light
Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective,...
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7186534 |
Potent inhibitors of human 9-cis retinol dehydrogenase
The cDNA sequence of the human 9-cis-retinol dehydrogenase enzyme is disclosed.
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7186990 |
Method and apparatus for detecting and imaging the presence of biological materials
Method and apparatus for the detection of biological material on non-living surfaces in which samples are exposed to electromagnetic radiation of specific energies capable of exciting various...
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7183047 |
Reporter gene construct for the detection of HIV Rev and HIV Tat
The present invention relates to a reporter gene construct for the detection of the HIV Rev and HIV Tat proteins. Furthermore, the invention relates to a functionality test method for Rev and Rev...
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7183100 |
Aconitase
A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria...
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7183048 |
Kits and methods for determining the effectiveness of sterilization of disinfection processes
The invention relates to methods and kits and methods for assessing the effectiveness of a sterilization process by determining the release of dipicolinic acid (DPA) from bacterial or other spores...
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7183059 |
Synthesis of compounds and libraries of compounds
A method of generating a compound having at least one biological activity of a peptide. The method includes identifying a biologically active peptide, providing a first monomer which contains...
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7183046 |
Methods for identifying inhibitors of cytokinesis using CYK-4 proteins
Mammalian CYK-4 polypeptides, which are key molecules required for cytokinesis, and DNA molecules encoding them. Screening methods based on biochemical reactions relevant for the function of CYK-4...
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7183051 |
Diagnosis and treatment of cancer
The invention is based on the elucidation of a mechanism by which HPV promotes oncogenesis and provides a methods of diagnosing malignant tumors and methods of preventing the development of...
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7179587 |
Method and apparatus for high frequency interfacing to biochemical membranes
High frequency interfacing to biochemical membranes, such as supported bilayers and cell membranes, is carried out by supporting a biochemical membrane on a support surface while allowing access to...
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7179447 |
Type I interferon-producing cells and uses thereof
The present invention provides compositions for the treatment, inhibition or prevention of diseases or disorders, including cancer, immune diseases or disorders, and infectious diseases, comprising...
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7179600 |
Oligonucleotide chip composition and a method for analyzing a hepatitis C virus genotype using the composition
The present invention discloses a method for analyzing a HCV genotype by extracting RNA from plasma and serum, performing C-type hepatitis virus (HCV) RT-PCR and then making them react on an...
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7179627 |
Cyclooxygenase variants and methods of use
The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring...
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7176312 |
Kinase inhibitor scaffolds and methods for their preparation
General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic...
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7175980 |
Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
Methods of producing liquid handling biosensor devices are provided. The liquid handling biosensor devices allow detection of biomolecular interactions in liquid. The use of labels is not required...
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7175983 |
Adapter-directed display systems
The present invention provides adapter-directed display systems for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic...
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7176243 |
CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis
This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for...
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7176009 |
Sucrose phosphate synthase
This invention relates to an isolated nucleic acid fragment encoding a sucrose phosphate synthase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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7175999 |
Polynucleotide and polypeptide fat metabolism regulators and uses thereof
In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and...
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7173241 |
Sample plate for matrix-assisted laser desorption and ionization mass spectrometry
A method of making a sample plate for mass spectrometric analysis of a specimen is provided comprising applying a mask to a substrate to form at least one sample site. The sample plate comprises a...
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7172861 |
Activity-based assay for ricin-like toxins
A method of detecting N-glycosylase activity in a sample involves incubating an oligodeoxyribonucleotide substrate containing a deoxyadenosine or deoxyuridine residue with the sample to be tested...
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7172860 |
Apparatus and method for measuring activity signals of biological samples
The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a...
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7172871 |
Methods and compositions for modulating axonal outgrowth of central nervous system neurons
Methods and compositions for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following...
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7172859 |
System and method for optimizing tissue barrier transfer of compounds
The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and...
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7172858 |
Blood-based assay for dysferlinopathies
It has been discovered that dysferlin is expressed in blood and that individuals who lack dysferlin in muscle also lack it in CD14(+) cells. Based on these discoveries, blood-based tests for...
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7172864 |
Methods for electronically-controlled enzymatic reactions
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic...
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7169550 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of...
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