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7622299 |
Bioengineered tissue substitutes
In one aspect, the invention provides methods for forming a target tissue substitute. The methods of the invention comprise the following steps: (a) providing a scaffold comprising one or more...
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7445793 |
Support for tissue regeneration and process for producing the same
The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be...
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7192769 |
Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen...
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7122371 |
Modular cell culture bioreactor
An apparatus and method for a modular cell culture bioreactor comprises a plurality of chambers for cell culture; at least one reservoir containing a cell support medium; a plurality of conduits...
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7087431 |
Ex vivo generation of functional leukemia cells in a three-dimensional bioreactor
The present invention provides cultured leukemia cells. The method comprises isolating mononuclear cells, which contain leukemia cells, culturing the leukemia cells in a chamber having a...
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7015038 |
Method and apparatus for preparing and culturing cells
A method and an apparatus for preparing and culturing cells, particularly bone marrow stromal cells. The method includes the steps of placing an oxygenator and a scaffold in a container, such as a...
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7008634 |
Cell growth substrates with tethered cell growth effector molecules
Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and...
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6960427 |
Process for producing a vascularized bioartificial tissue and an experimental reactor for carrying out the process
The invention concerns a process for producing a three-dimensional bioartificial tissue having viable cells in or on a matrix, and by which cells and matrix can be cultivated into a tissue or a...
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6943008 |
Bioreactor for cell culture
A bioreactor for cell culture includes a chamber having three channels therethrough for conducting fluids, the three channels including an upper channel, a middle channel, and a lower channel, each...
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6875605 |
Modular cell culture bioreactor and associated methods
An apparatus and method for a modular cell culture bioreactor comprises a plurality of chambers for cell culture; at least one reservoir containing a cell support medium; a plurality of conduits...
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6759245 |
Cell culture systems and methods for organ assist devices
The invention features modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated...
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6667049 |
Relic process for producing bioresorbable ceramic tissue scaffolds
A relic process is used to produce bioresorbable ceramic scaffolds that can be used for in vitro or in vivo growth of human or animal tissue such as bone or cartilage. The process involves...
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6562374 |
Biodegradable porous polymer scaffolds for tissue engineering prepared from an effervescent mixture and its preparation
The present invention provides a method for preparing biodegradable porous polymer scaffolds for tissue engineering, comprising: a) fabricating a polymer sample from a polymer solution containing...
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6399380 |
Native-state histoculturing skin extracellular support
Methods and compositions for a native-state histoculturing system for skin are disclosed. Skin samples are placed on an extracellular support matrix immersed in a medium whereby the internal...
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6281007 |
Methods and apparatus for the conditioning of ligament replacement tissue
Apparatus and methods are disclosed for maturing an elongate replacement tissue construct in vitro prior to use of the replacement construct in vivo as, for example, a ligament. The tissue is...
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6146892 |
Fibrillar matrices
Methods and compositions are described that provide three-dimensional fibrillar matrices useful as, among other things, structural prosthetics and scaffolds for cells. The porous fibrillar matrices...
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6140039 |
Three-dimensional filamentous tissue having tendon or ligament function
A stromal cell-based three-dimensional cell culture system is provided which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal...
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6093558 |
Binding protein of biologically active compositions to an adhesive formulation on a substrate
Compositions and methods are provided for adhering and binding biologically active proteins and protein-containing composites to substrates. Adhesive formulations comprising a nonproteinaceous...
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6022743 |
Three-dimensional culture of pancreatic parenchymal cells cultured living stromal tissue prepared in vitro
A stromal cell-based three-dimensional cell culture system is prepared which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal...
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6017760 |
Isolation and culture of porcine hepatocytes
A perfusion device such as a liver assist device containing a housing defining a perfusion inlet and a perfusion outlet, a porous membrane structure mounted within said housing to define a...
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5902741 |
Three-dimensional cartilage cultures
The present invention relates to a method of stimulating the proliferation and appropriate cell maturation of a variety of different cells and tissues in three-dimensional cultures in vitro using...
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5858721 |
Three-dimensional cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5849579 |
Native-state histoculturing method for skin
Methods and compositions for a native-state histoculturing system for skin are disclosed. Skin samples are placed on an extracellular support matrix immersed in a medium whereby the internal...
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5849588 |
Methods of use of a three-dimensional liver cell and tissue culture system
The present invention relates to a three-dimensional cell and tissue culture system. In particular, it relates to this culture system for the long term culture of liver cells and tissues in vitro...
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5846828 |
Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments
An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing heart valves is disclosed. Specifically, the present invention relates to an apparatus and method for...
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5792603 |
Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing vascular grafts is disclosed. Specifically, the present invention relates to an apparatus and method for...
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5786215 |
Method for culturing animal cells
An apparatus and method for the in vitro culturing of animal cells, e.g., mammalian cells, to attain mass growth of the cells per se and/or to recover cell-secreted products of interest therefrom,...
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5763255 |
Inducing epithelial cell differentiation with dried native fibrillar collagen
Cell culture substrates made of dried films of native fibrillar collagen produced by a method in which collagen fibers are hydrolyzed in acid, solubilized, and reformed as gels on porous surfaces...
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5763267 |
Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures
An apparatus for the large scale culturing and packaging of cell suspensions, three dimensional tissue, and other biological systems is disclosed. The apparatus includes a plurality of flexible or...
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5736399 |
Medium-penetrating cell culture carrier, a culturing method and a device using this carrier
The present invention provides a medium-penetrating culture carrier comprising a plurality of natural or synthetic threads or the woven body thereof, a method for adhering cells onto this carrier...
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5643561 |
Coating composition for culturing animal cells and method for culturing of the cells in serum-free condition
Disclosed is a coating compositions for culturing animal adhesive cells comprising a water-insoluble polymer dissolved in a lower alcohol or an aqueous lower alcohol which enable to enhance the...
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5624840 |
Three-dimensional liver cell and tissue culture system
The present invention relates to a three-dimensional cell and tissue culture system. In particular, it relates to this culture system for the long term culture of liver cells and tissues in vitro...
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5605829 |
Stroma-derived stem cell proteoglycan growth factor
An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian...
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5602028 |
System for growing multi-layered cell cultures
Method and apparatus for growing cell cultures consisting of a plurality of layers includes a chamber for submerging cells in a medium while supporting and binding them to a semi-permeable...
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5585266 |
Immobilized cell bioreactor
An immobilized cell bioreactor is disclosed wherein the cells are harbored within or upon an immobilization matrix including cell support sheets comprised of common textile fabric. The cell support...
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5580781 |
Three-dimensional tumor cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5578485 |
Three-dimensional blood-brain barrier cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5518915 |
Three-Dimensional mucosal cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5501971 |
Method and apparatus for anchorage and suspension cell culture
A method and apparatus cultivates anchorage and nonanchorage cell in a reactor. A reactor includes a basket type packed bed and an internal recirculation device. The basket includes a top and...
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5478739 |
Three-dimensional stromal cell and tissue culture system
The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three-dimensional matrix while cycling the cultures between metabolically favorable...
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5476783 |
Bioreactor method of culturing and propagating cells with a woven motionless mixing element
A bioreactor, motionless mixing element with attached cells, and method for the enhanced cultivation and propagation of cells in a bioreactor method, and which bioreactor comprises a housing and...
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5385836 |
Nonwoven fabric coated with a mixture of silk fibroin, gelatin and insolubilized chitosan for use as a carrier for animal cells
A carrier for adhering animal cells during culturing or for immobilization of animal cells is produced by coating a porous substrate with a cell adhesive material in the form of a mixture with...
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5286641 |
In vitro culture method for a fertilized ovum of a hen
A fertilized ovum is recovered from an upper portion of a magnum of an oviduct of a dead hen 60 to 80 minutes after oviposition. The fertilized ovum is placed in a container containing a thin...
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5266476 |
Fibrous matrix for in vitro cell cultivation
There is provided a matrix and cultivation system for anchorage dependent cells. The matrix is characterized by a substantially increased available effective surface area for cell attachment which...
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5254471 |
Carrier for cell culture
A carrier for cell culture comprising ultra fine fibers with a fineness of not more than 1.0 denier. The carrier makes it possible for the cells to retain their differentiation and proliferation...
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5151362 |
Apparatus containing a septum which impedes cell permeation for cell culture and method of use
By culturing cells in an apparatus containing a first zone in which a cell suspended medium is present and a second zone in which liquid containing a physiological saline solution and/or nutrient...
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5131907 |
Method of treating a synthetic naturally occurring surface with a collagen laminate to support microvascular endothelial cell growth, and the surface itself
A novel implantable prosthesis for implantation in human patients is disclosed which comprises a synthetic substrate and a Type IV/V collagen surface layer seeded with a confluent monolayer of...
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5100783 |
Weighted microsponge for immobilizing bioactive material
Weighted microsponges formed of a porous, biostable matrix of a biocompatible polymer containing an inert weighing material are prepared suitable for use in culturing organisms in motive reactor...
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4997753 |
Weighted collagen microsponge for immobilizing bioactive material
Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the...
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4642292 |
Method for isolation of connective tissue biomatrix
A method is disclosed for isolation of connective tissue fibers, called biomatrix, containing a significant portion of the extracellular matrix, i.e., basement membrane components and components of...
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