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8183033 |
Methods for preparing and performing analyses
The invention relates to methods for preparing and performing quantitative PCR analyses, a new sealing device and a new use. According to the invention, a sample vessel containing the samples to be...
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8110385 |
Linear and membrane-like biodevices and bioreactors
A linear biodevice is provided with fibers that have a curved portion in its cross section approximately perpendicular to the longitudinal direction and approximately spherical adhesive cells that...
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RE42575 |
Engineering of strong, pliable tissues
It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by...
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RE42479 |
Engineering of strong, pliable tissues
It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by...
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7955867 |
High throughput cell-based assays, methods of use and kits
In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation....
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7939296 |
Method for production of recombinant human FSH
Disclosed is a method for production of recombinant human FSH in high yield and a high purity. The method comprises the steps of: (a) culturing recombinant human FSH-producing mammalian cells in a...
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7795027 |
Extracellular matrix composite materials, and manufacture and use thereof
Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are...
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7704740 |
Nanofibrillar structure and applications including cell and tissue culture
A nanofibrillar structure for cell culture and tissue engineering is disclosed. The nanofibrillar structure can be used in a variety of applications including methods for proliferating and/or...
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7678573 |
Method of preparing a conditioned medium from a confluent stromal cell culture
A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method...
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7622299 |
Bioengineered tissue substitutes
In one aspect, the invention provides methods for forming a target tissue substitute. The methods of the invention comprise the following steps: (a) providing a scaffold comprising one or more...
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7534609 |
Method of expanding undifferentiated hemopoietic stem cells
A method of expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) obtaining the undifferentiated hemopoietic...
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7354773 |
Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry
A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such...
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7008634 |
Cell growth substrates with tethered cell growth effector molecules
Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and...
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6974679 |
Support with collagen base for tissue engineering and manufacture of biomaterials
The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin,...
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6967100 |
Pancreatic islet cell growth factors
The present invention relates generally to growth factors and more particularly to growth factors which are capable of stimulating or otherwise facilitating formation of insulin-secreting cells....
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6913762 |
Stent having non-woven framework containing cells
Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.
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6911201 |
Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor
A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the...
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6780612 |
Methods for the propagation of lytic organisms
The present invention provides a method for the propagation of lytic organisms which comprises the infection of the cells of a stable cell line within a hollow fibre bioreactor with a lytic...
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6670179 |
Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth
A cell and substrate system and nerve regeneration implant are disclosed including a carbon nanotube and a neuron growing on the carbon nanotube. Both unfunctionalized carbon nanotubes and carbon...
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6627422 |
Device containing cell-supporting yarn matrix encapsulated in a semi-permeable membrane
A device is provided containing cells or tissue distributed on a filamentous cell-supporting matrix which is encapsulated by a semi-permeable membrane which can be immunoisolatory. The matrix may...
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6616912 |
Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells
A bi-component microporous hollow fiber membrane structure is provided for in vivo propagation of cells and use in testing of the effect of medical treatments on cells within the structure. The...
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6541023 |
Use of collagen of aquatic origin for the production of supports for tissue engineering, and supports and biomaterials obtained
Use of collagen of aquatic origin for the production of supports for tissue engineering is disclosed. The collagen may be obtained from fish skin, preferably in its native form. Novel tissue...
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6482645 |
Methods and compositions for producing artificial fascia
The present invention describes methods for producing artificial fascial slings and their subsequent use in treating subjects with urinary incontinence. The invention is based, in part, on the...
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6368859 |
Methods and compositions for producing a fascial sling
The present invention describes methods for producing artificial fascial slings and their subsequent use in treating subjects with urinary incontinence. The invention is based, in part, on the...
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6309635 |
Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
A method is provided whereby cells having a desired function are seeded on and into biocompatible, biodegradable or non-degradable porous polymer scaffolding matrix, previously implanted in a...
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6303136 |
Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
A device is prepared having cells or tissue attached to a non-degradable filamentous matrix surrounded by a semi-permeable membrane. The matrix is preferably formed of a plurality of monofilaments...
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6228607 |
Bioreactor
The invention relates to a bioreactor for a cell treatment of a medium. Said bioreactor comprises an element defining a chamber in which cells for treating the medium are located, a liquid...
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6140039 |
Three-dimensional filamentous tissue having tendon or ligament function
A stromal cell-based three-dimensional cell culture system is provided which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal...
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6051425 |
Method for producing tissue formation and tissue culture kit
A matrix for tissue culture comprising two kinds of sponges having at least one different physical property and/or at least one different chemical property; a method for culturing tissue using said...
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6043079 |
Cell growth apparatus for histophysiologic culture
The present invention provides an apparatus and methods for incubating cells which rely on the use of a semipermeable membrane placed between two planar members, at least one planar member having...
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6022743 |
Three-dimensional culture of pancreatic parenchymal cells cultured living stromal tissue prepared in vitro
A stromal cell-based three-dimensional cell culture system is prepared which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal...
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5998184 |
Basket-type bioreactor
Improved hollow fiber bioreactor systems and cell culture methods are described. The improvement includes means which may be a novel basket bioreactor for extending the extracapillary space of a...
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5976878 |
Method and apparatus for preparing composite skin replacement
A method and apparatus for forming a permanent, composite skin replacement consisting of an epidermal component and a porous, resorbable, biosynthetic laminated dermal membrane component for use in...
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5943821 |
Process for packaging plant tissues cultured in vitro for transport
Plant tissues which have been cultured in vitro are packaged with a nutritive medium for survival of the tissues in a sealed sterile container and with support members so that the plant tissues are...
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5942436 |
Culturing liver cells
A method for maintaining hepatocytes in culture includes providing the hepatocytes with a support, the support including extracellular matrix, the support having a configuration that permits each...
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5902577 |
Insulin-secreting cell lines, methods of production and use
The invention relates to the field of biology and, in particular, to the field of cellular biology. The invention concerns a novel glucose-sensitive cell line designated β cell line (INS-I) ...
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5863531 |
In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
A stromal cell-based three-dimensional cell culture system is provided which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal...
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5858721 |
Three-dimensional cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5849588 |
Methods of use of a three-dimensional liver cell and tissue culture system
The present invention relates to a three-dimensional cell and tissue culture system. In particular, it relates to this culture system for the long term culture of liver cells and tissues in vitro...
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5804178 |
Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
A matrix structure containing attached cells such as endocrine cells, fibroblasts, endothelial cells or genitourinary cells is implanted in a patient adjacent tissue having a high surface area and...
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5780281 |
Method of preparing a low-density porous fused-fiber matrix
A method is provided for preparing a low density porous rigid fused-fiber matrix having a density of between about 3.5 and 5.5 pounds/cubic foot and a free volume of between about 90-98 volume...
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5770193 |
Preparation of three-dimensional fibrous scaffold for attaching cells to produce vascularized tissue in vivo
Fibers of a biocompatible, biodegradable or non-biodegradable, synthetic polymer are provided, and are formed into a three-dimensional scaffold. The fibers of the scaffold may have a branched...
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5770417 |
Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
A cell-scaffold composition is prepared in vitro for implanting to produce functional organ tissue in vivo. The scaffold is three-dimensional and is composed of hollow or solid fibers of a...
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5766584 |
Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells
A composition and method are provided for inhibition of vascular smooth muscle cell proliferation following injury to the endothelial cell lining of a blood vessel such as resulting from...
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5741685 |
Parenchymal cells packaged in immunoprotective tissue for implantation
Cells for implantation into a patient are packaged within a barrier of immunoprotective tissue prior to implantation to obviate or minimize rejection of the cells. The preferred immunoprotective...
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5736372 |
Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces and bone are disclosed. In the preferred embodiments, chondrocytes are grown on...
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5686303 |
Method of growing vertebrate skin in vitro
A method of growing complete vertebrate skin in vitro, which comprises obtaining a segment of vertebrate skin, positioning the skin segment in an artificial cell-growth medium containing sufficient...
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5622857 |
High performance cell culture bioreactor and method
A high performance hollow fiber bioreactor having concentric hollow fiber bundles: a central hollow fiber bundle supplies media, and an outer array supplies oxygen needed for cell culture. Useful...
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5460939 |
Temporary living skin replacement
The present invention relates to a living skin replacement. In particular, it relates to a biosynthetic dressing material composed of a living stromal tissue prepared from stromal cells such as...
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5260210 |
Blood-brain barrier model
An in vitro model of a blood-brain barrier comprising a porous solid support upon which is disposed an essentially confluent monolayer of brain microvascular endothelial cells in contact with...
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