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7432253 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula:
where R1 is selected from among —CH 3 and —CH 2 —CH 3 .
Cat+ is an organic or...
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7374934 |
Cell populations and methods of production thereof
The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay...
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7354729 |
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to...
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7354730 |
High-throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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RE39792 |
Method for culturing Chinese hamster ovary cells
A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal...
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7247480 |
Method for producing dendritic cells
Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one...
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7198948 |
Methods and compositions for obtaining mature dendritic cells
We describe an improved method for generating sizable numbers of mature dendritic cells from nonproliferating progenitors in human blood. The first step or “priming” phase is a culture of T...
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7101711 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula:
where R1 is selected from among —CH 3 and —CH 2 —CH 3 ,
Cat+ is an organic or...
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7029671 |
Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof
The invention relates to a method for activating human-derived antigen-presenting cells by in vitro cultivation with at least one of the glycoside compounds represented by formula (A) or salts...
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6982168 |
Immortal human prostate epithelial cell lines and clones and their applications in the research and therapy of prostate cancer
The present invention relates to immortalized, malignant, human, adult prostate epithelial cell lines or cell lines derived therefrom useful in the diagnosis and treatment of prostate cancer. More...
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6960473 |
In vitro mass production of human erythroid cells from the blood of normal donors and thalassemic patients
We describe a new two-step culture method for mass production in vitro of erythroid cells from either CD34 + (10 5 cells/mL) or light-density (10 6 cells/mL) cells purified from the blood of...
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6919206 |
Medium containing flt3 ligand for culturing hematophoietic cells
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is...
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6838081 |
Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient
The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in...
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6828147 |
Method of modifying cytotoxic cells and uses thereof
TALL-104 cells, and other cytotoxic T cell lines, may be modified to increase the cytotoxicity thereof, to enhance growth properties, and/or to provide a preferred phenotype, e.g., expression of...
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6805869 |
Cellular vaccines and immunotherapeutics and methods for their preparation
The present invention provides a method for enhancing the immunogenicity of weakly immunogenic or non-immunogenic cells, resulting in a cellular vaccine that can stimulate T cell activation, which...
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6733746 |
Hematopoietic cell culture nutrient supplement
The present invention provides a serum-free supplement which supports the growth of hematopoietic cells in culture. Also provided are a medium comprising a basal medium supplemented with the...
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6692958 |
Cord blood-derived activated lymphocytes, preparations containing said lymphocytes as main ingredient and method and kit for producing said preparations
Activated lymphocytes derived from cord blood are excellently effective for preventing and treating various types of tumors and various types of infection. With interleukin 2 and/or anti-CD3...
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6667034 |
METHODS FOR REGULATING THE SPECIFIC LINEAGES OF CELLS PRODUCED IN A HUMAN HEMATOPOIETIC CELL CULTURE, METHODS FOR ASSAYING THE EFFECT OF SUBSTANCES ON LINEAGE-SPECIFIC CELL PRODUCTION, AND CELL COMPOSITIONS PRODUCED BY THESE CULTURES
Methods, including culture media conditions, which provide for in vitro human stem cell division and/or the optimization of human hematopoietic progenitor cell cultures and/or increasing the...
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6586243 |
Directed maturation of CD34 negative stem cells to programmable antigen presenting cells
A method is described whereby dendritic cells derived from the CD34+ and CD 34− hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may...
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6558949 |
Media for culturing human cells comprising human serum and method for culturing human cells using the same
This invention relates to media for culturing human cells that the proliferation speed of human cells is increased and the cell expression type is stably manifested, and to a method for culturing...
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6511848 |
Process for producing and multiplying lymphocytes
A method for culturing and/or multiplying lymphocytes in cell culture medium which contains as lymphocyte growth factor and additionally, aurin tricarboxylic acid, ciclosporin, tacrolimus, and/or...
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6432711 |
Embryonic stem cells capable of differentiating into desired cell lines
An embryonic stem cell which may be induced to differentiate homogeneously into a desired primary cell line. The embryonic stem cell may be engineered with DNA, which encodes a protein or...
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6355237 |
Methods for using the obese gene and its gene product to stimulate hematopoietic development
The present invention relates to methods for using various forms of a novel receptor expressed by hematopoietic and endothelial cells. An additional variant form of this receptor has been detected...
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6344192 |
Use of interleukin-15
The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of...
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6251671 |
Compositions and methods of making embryonic stem cells
The invention relates to cell proliferation, cell differentiation, male infertility, male fertility and to compositions and methods involved therein. Also methods of culturing spermatogonial stem...
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6251665 |
Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom
A method is described whereby dendritic cells derived from the CD34+ and CD34- hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be...
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6165785 |
Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications
A method of treatment using immune system suppressor cells and immune system stimulator cells comprises providing stem cells; combining the stem cells with lymphoid-derived cells to produce a...
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6110739 |
Method to produce novel embryonic cell populations
The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay...
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6077519 |
Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients
Methods are provided for eluting peptides that are bound to major histocompatibility complex ("MHC") molecules expressed on the cell surfaces of viable cells that have at least one MHC-peptide...
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6004812 |
In-vitro T-lymphopoiesis system
The present invention provides an in vitro T-lymphopoiesis system in which a population of T-cells is produced from precursor cells expressing CD34. The T-lymphopoiesis system of the present...
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5928639 |
Immunotherapy of cancer with allogeneic lymphocytes
Methods have been discovered for treating minimal residual disease following removal of most or a substantial fraction of malignant cells from a cancer patient. An autologous stem cell transplant...
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5919700 |
Method of proliferating natural killer cells with IL-16
The invention relates to a method of stimulating the proliferation of natural killer cells with in vitro IL-16. A mixed lymphocyte cell population which contains natural killer cells can be nylon...
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5914268 |
Embryonic cell populations and methods to isolate such populations
The present invention relates to novel pluripotent embryonic cell populations derived from embryonic stem cell populations and methods to produce such pluripotent embryonic cell populations....
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5874308 |
Compositions and methods for modulating cell proliferation using growth factor-polysaccharide binding fusion proteins
Methods and compositions are provided for in vitro expansion of growth factor dependent cells. Expansion is effected through the use of growth factor conjugates that include a growth factor such as...
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5861315 |
Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
Stem cell factor in combination with soluble interleukin-6 receptor, interleukin-6, for gp130 signaling, supports the proliferation, differentiation and terminal maturation of blood cells from...
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5846827 |
Methods for ex vivo therapy using peptide-loaded antigen presenting cells for the activation of CTL
Methods for activating cytotoxic T lymphocytes (CTL) in vitro are presented in conjunction with methods for using the activated CTL for therapy in vivo. Additionally, a method for killing specific...
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5830464 |
Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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5827642 |
Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
The present invention provides a rapid expansion method (termed "REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes. REM involves culturing...
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5811301 |
In vitro method for producing differentiated universally compatible human blood cells
In vitro production of clinically useful quantities of single species of mature, differentiated human blood cells is carried out by a method in which human pluripotent hematopoietic stem cells,...
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5807744 |
Use of interferon γ for the inhibition of proliferation and differentiation of primitive hematopoietic progenitor cells
The invention provides a method for inhibition of proliferation of primitive hematopoietic progenitor cells and hematopoietic stem cells, by incubating preparations containing said cells with...
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5780301 |
Serum-free medium for cultivation of postnatal central neurons
Disclosed is a synthetic medium with PDGF, vitronectin, IL-1β and BSA added to Eagle's minimum essential medium or medium with transferrin, insulin, progesterone and putrescine further added...
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5766944 |
T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
A procedure for carrying out T cell differentiation of CD34+ stem cells in an in vitro culture of thymic epithelial fragments whereby the differentiated T cells achieve full immunocompetence. The...
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5759856 |
Cell culture system
Disclosed is a method for the culture of higher eukaryotic cells which are dependent for survival on an exogenous factor. The method involves co-culturing the factor-dependent cells with an...
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5744361 |
Expansion of human hematopoietic progenitor cells in a liquid medium
The use of individual or combinations of cytokines, particularly IL-3, GM-CSF, and c-kit ligand are employed for long-term hematopoiesis in serum free culture in the absence of stromal cells. The...
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5705162 |
FeLV therapeutic agent, method of its preparation, and method of treating FeLV infection therewith
The present invention broadly relates to a therapeutic agent effective in mitigating disease associated with Feline Leukemia Virus (FeLV) in a feline infected with FeLV. A feline is an animal of...
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5610056 |
Use of stem cell factor interleukin-6 and soluble interleukin-6 receptor to induce the development of hematopoietic stem cells
Stem cell factor in combination with interleukin-6 and soluble interleukin-6 receptor supports proliferation, differentiation and terminal maturation of erythroid cells from normal human...
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5599703 |
In vitro amplification/expansion of CD34.sup.+ stem and progenitor cells
The present invention relates to a method of amplifying in vitro stemcells. In this method hematopoietic CD34 + stem and progenitor cells are isolated from human bone marrow and contacted with...
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5580724 |
Differential expansion of fetal stem cells in maternal circulation for use in prenatal genetic analysis
The methods of the present invention use blood of pregnant females and fetal cell amplification to facilitate prenatal diagnosis without invading fetal space. This method is less invasive and...
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5472867 |
Ex vivo expansion of peripheral blood progenitor cells
Patients suffering from certain types of cancer are treated by high-dose chemotherapy. In order to allow a recovery a process for the ex vivo expansion of peripheral blood progenitor cells is...
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5460964 |
Method for culturing hematopoietic cells
A method for culturing mammalian hematopoietic, preferably stem cells, is provided comprising maintaining a population of human hematopoietic cells in a non-contacting relationship to a population...
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