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8183297 |
Medium and device for proliferation of stem cells and treatment of cancer-related stem cell with resveratrol
The invention relates to a device for selecting stem cells with a serum free medium for amplification of stem cells. The invention also relates to a method of treating or preventing diseases caused...
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8183040 |
Methods for in vitro differentiation of Th-17+cells
The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells). The instant method may be...
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8178089 |
Neuronal progenitors from feeder-free human embryonic stem cell culture
The present invention relates to methods for producing feeder cell-free neuroprogenitor cells (preferably adherent) from embryonic stems cells, preferably human embryonic stem cells, the feeder...
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8178349 |
Homogeneous neural precursor cells
This invention provides pure populations of neural precursor cells, capable of differentiation into neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell...
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8173426 |
Muller cells de-differentiated to cells expressing markers of neural cell progenitors
A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells; and (ii) culturing the cells in the presence of ...
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8173427 |
Method of producing a population of post-mitotic cells of the neutrophil lineage
A method is provided for producing a population of post-mitotic cells of the neutrophil lineage, which method comprises the ex vivo steps of: (a) providing a population of cells comprising...
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8173612 |
Chemotherapy involving antisense oligonucleotides for preventing and/or treating pulmonary fibrosis
The invention provides, in the treatment of malignant tumors, antisense DNA oligonucleotides which are effective in inhibiting the expression of a wild type COL1A1 gene, in combination with a...
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8168430 |
Method for preparation of hepatocyte using ES cell
This invention relates to an agent for promoting differentiation of an ES cell, preferably an agent for promoting differentiation of an ES cell into a hepatocyte or a prophylactic agent for...
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8168606 |
RNAi inhibition of alpha-ENaC expression
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified...
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8168429 |
Method of amplifying hematopoietic stem cell and hematopoietic progenitor cell
The present invention provides useful means in an expansion culture system for a hematopoietic cell (hematopoietic stem cell, hematopoietic progenitor cell). Specifically, the present invention...
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8168428 |
Method to modulate hematopoietic stem cell growth
The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease...
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8163553 |
Human trophoblast stem cells and use thereof
Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, FGFR-2, Oct4,...
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8158422 |
Erythroid cells producing adult-type β-hemoglobin generated from human embryonic stem cells
Methods and compositions of erythroid cells that produce adult β-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
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8158598 |
Compositions and their uses directed to PTPR alpha
Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRα in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses ...
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8158423 |
Method of making a hair
A method of making a hair, including a step of culturing an undifferentiated cell of a mammal to produce an embryoid body and a step of further culturing the embryoid body is provided, wherein the...
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8158597 |
Modulation of diacylglycerol acyltransferase 1 expression
Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding...
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8158120 |
Cardiac muscle repair or regeneration using bone marrow-derived stem cells
Disclosed are compositions and methods for repairing and/or regenerating cardiac tissue by administering adult bone marrow-derived stem cells to an individual. These cells can be administered as a...
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8158421 |
Cardiomyocyte differentiation
The present invention provides a method of enhancing the efficiency of differentiation of hES cells into cardiomyocytes which method comprises incubating the cells under serum free conditions. The...
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8158424 |
Primate pluripotent stem cells cultured in medium containing gamma-aminobutyric acid, pipecolic acid and lithium
Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an...
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8158121 |
Cardiac muscle regeneration using mesenchymal stem cells
Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered...
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8158420 |
Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5
The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides...
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8153604 |
CNS-tumor treatment method and composition
A method, aerosol composition, and aerosolizing device for treating a brain tumor in a subject are disclosed. The method includes intranasally administering to the subject, an amount of a...
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8153424 |
Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority...
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8153427 |
Cardiomyocytes and methods of producing and purifying cardiomyocytes
The invention provides methods for producing a culture of cardiomyocytes and cultures of cardiomyocytes. Exemplary methods of producing and cultures of cardiomyocytes include a population of cells...
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8153428 |
Use of TGF beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells
This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies...
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8148344 |
Compositions and methods for mediating RNAi in vivo
This invention relates to new formulated lipid particles (FLiPs) comprising at least one of a single or double stranded oligonucleotide, where the oligonucleotide has been conjugated to a lipophile...
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8148151 |
Differentiation of primate pluripotent cells to hepatocyte-lineage cells
Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent...
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8148152 |
Method for the preparation of embryoid bodies (EBs) and uses thereof
Provided are means and methods for producing embryoid bodies (EBs) from multi- or pluripotent cells. In particular, a method of generating embryoid bodies (EBs) is described comprising agitation of...
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8148148 |
Neural progenitor cell populations
This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as...
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8143233 |
RNA aptamers and methods for identifying the same
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA...
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8143230 |
Compounds and methods for modulating expression of PCSK9
The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense...
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8143060 |
Method of assessing the viability of thawed developmentally competent embryos
The invention relates to a method of assessing the viability of a thawed cell wherein the cell is a gamete, an embryo, a karyoplast, a putative stem cell population, a stem cell precursor...
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8143059 |
Method for identification of cell growth or differentiation factors
The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay...
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8137969 |
Neural progenitor cells derived from embryonic stem cells
The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the...
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8137970 |
Methods for inducing the differentiation of hematopoietic stem cells into megakaryocytes and platelets, and gene controlling the differentiation
The present invention relates to a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets, more particularly, a method for inducing the...
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8137968 |
Selected endothelial progenitor cells and methods for use
The present invention is a method for preparing a substantially pure population of endothelial progenitor cells wherein said cells express Flk-1, CD34, α5β1 integrin fibronectin, and vWF and e...
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8137934 |
Regeneration and neogenesis of retinal photoreceptor cell using Otx2 gene
The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The...
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8138159 |
Composition for inhibiting function of human Flt3
To provide a means of controlling the function of Flt3. A composition for inhibiting the function of human Flt3, a method of inducing apoptosis by using the composition, and a kit for the method.
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8133877 |
Composition comprising an antisense sequence implicated in the regulation of angiogenesis
Therapeutic compositions used in the field of angiogenesis include nucleotide sequences of genes, the involvement of the genes in the angiogenesis mechanism having been demonstrated by the...
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8133730 |
Generation of neural stem cells from undifferentiated human embryonic stem cells
The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into...
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8133732 |
Method of forming myeloid precursor cells from human embryonic stem cells
This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells...
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8133725 |
Bone marrow stromal cells comprising a nucleic acid encoding a notch intracellular domain
There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a...
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8133729 |
Biomimetic urothelium
Urothelium is the specialized endothelium that lines much of the mammalian urinary tract. This invention relates to the field of in vitro urothelial culture. Previous methods produce tissue lacking...
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8133874 |
Oligonucleotide or its functional homologue, a composition comprising the same and a method of treating B cell neoplasm
The invention provides an oligonucleotide with a sequence of SEQ ID NO: 1 or its functional homolgue, a composition comprising the same and a method for treating B cell neoplasm by using the...
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8133727 |
In vitro human B lymphopoiesis culture system
The present disclosure relates to systems, methods and compositions for the generation of antibody-producing B cells in vitro. Some embodiments are related to an in vitro system for generating...
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8133731 |
Production of primate neural stem cells through expression of pax6
A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
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8129187 |
Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present...
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8124067 |
Method for immunotherapy of tumors
A method for making dendritic cells reactive to an antigen comprises obtaining a sample of dendritic cells and contacting the cells with the antigen and at least one Toll-like receptor stimulant....
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8119401 |
IL-10 gene transfer to peripheral mononuclear cells
The present invention to methods for producing mononuclear cells overexpressing IL-10. The method comprises the ex vivo introduction of an expression construct comprising a nucleotide sequence...
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8119612 |
RNAi inhibition of alpha-ENaC expression
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified...
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