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7618947 |
Modulation of HIF-1 beta expression
Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of...
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7618621 |
Mammalian multipotent neural stem cells and compositions, methods of preparation and methods of administration thereof
This invention relates to novel mammalian multipotent neural stem cells (MNSCs), compositions thereof, and methods of preparing and administering the cells to diseased, aged or damaged tissue such...
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7615677 |
Assessment method
A method of assessing the viability of a cell comprises incubating the cell in a culture medium. The culture medium includes a plurality of amino acids and the change in concentration in the medium...
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7611895 |
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
The invention relates to materials and methods for producing equivalents of tissues of the ocular surface, especially conjunctival tissue equivalents. The method of the invention involves biopsy of...
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7611852 |
Functional cardiomyocytes from human embryonic stem cells
Human embryonic stem cells form embryoid bodies in culture which contain differentiated human cells. Some of the human cells in embryoid bodies differentiate into cardiomyocytes. Here the...
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7605128 |
Neurogenerative or neurotrophic factors for mitigating a symptom of ischemia
This invention pertains to the identification of neurogenerative and/or neurotrophic factors that can induce migration of stem cells to neural tissue and/or induce proliferation and/or...
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7604993 |
Combined regulation of neural cell production
This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating...
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7604992 |
Generation of neural stem cells from undifferentiated human embryonic stem cells
The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into...
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7604991 |
Method of generating islet beta-cells from exocrine pancreatic cells
The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF...
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7604990 |
Methods of regulating differentiation in stem cells
The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and...
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7601884 |
Method of producing cloned animals by demecolcine treatment
A cloned animal is produced by demecolcine treatment characterized by culturing the nuclear transfer embryo in vitro and transferring the embryo in vivo. This significantly improves in vitro...
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7601700 |
Modulation of eIF4E expression
Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid...
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7601534 |
Method for multiplying stem cells
The use of a cellular development inhibitor in a controlled manner in order to maintain an undifferentiated stem cell state, especially one of human stem cells, whereby cell division is permitted.
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7595295 |
Use of pleiotrophin to promote neurogeneration
The invention provides methods for promoting neuron survival in patients by administering pleiotrophin, or nucleic acids encoding pleiotrophin. Uses of the invention include promoting neuron graft...
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7592177 |
Compositions and methods for inducing cell dedifferentiation
The present invention provides compositions and methods for dedifferentiating lineage committed mammalian cells.
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7589074 |
Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents
A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for...
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7588937 |
Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells...
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7588936 |
Generating teeth from bone marrow cells
The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for...
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7585673 |
γ-heregulin
A novel member of the heregulin superfamily has been identified which is designated “γ-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a...
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7582292 |
Adipose tissue derived stromal cells for the treatment of neurological disorders
The present invention relates to a treatment of neural injury and neurodegenerative diseases. Also included in the present invention is the use of adipose tissue derived stromal cells for the...
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7579329 |
P450RAI-2 (P450 cytochrome 26B), encoding nucleic acid molecules and methods and uses thereof
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. It is...
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7579188 |
Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem...
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7575926 |
Method of identification of compounds effective against suppressed cancer cells
A method for identifying compounds capable of targeting suppressed cancer cells, the method including the steps of comparing the response to a test compound of cancer cells grown on a suppressing...
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7566568 |
Method for generating highly active human dendritic cells from peripheral blood mononuclear cells
The present invention relates to a process for deriving dendritic cells from mononuclear cells in culture comprising the step of putting in contact type I IFN with said mononuclear cells. Dendritic...
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7563583 |
Heregulin variants
The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human...
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7560281 |
Use of TGF beta superfamily antagonists to make dopaminergic neurons from embryonic stem cells
This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies...
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7560105 |
Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses
The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in...
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7553663 |
Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The...
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7547547 |
Bioprocess for producing uniform embryoid bodies from embryonic stem cells in a high density bioreactor
The present inventors identified aggregation of embryonic stem cells and embryoid bodies (EBs) as the cause of the difficulty in generating large numbers of the embryonic stem cells (ES)...
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7544511 |
Stable neural stem cell line methods
A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible...
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7541431 |
Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto
The present invention relates to compositions and method for the modulation of Wnt pathway signaling. The Wnt signaling pathway is instrumental in the regulation of cell proliferation,...
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7541344 |
Modulation of survivin expression
Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded...
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7541186 |
Method of generating human retinal progenitors from embryonic stem cells
Methods are provided for the in vitro differentiation of human retinal progenitor cells from embryonic stem cells.
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7541185 |
Methods for identifying factors for differentiating definitive endoderm
Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which...
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7534765 |
Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin
The present invention relates to a method to increase oligodendrocytes and oligodendrocyte precursor cells through administration of prolactin or a prolactin inducing agent.
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7534608 |
Methods of producing pancreatic hormones
Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells...
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7534607 |
Method of producing cardiomyocytes from mesenchymal stem cells
Methods are provided for producing cardiomyocytes suitable for various medical applications. In one embodiment, a method of producing cardiomyocytes is provided, which comprises culturing...
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7534606 |
Placental stem cell and methods thereof
The present invention describes stem cells obtained from post-partum placenta and their methods of obtaining and culturing. The present invention also describes compositions comprising placental...
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7531355 |
Methods and compositions for smooth muscle reconstruction
This invention also provides a purified or isolated population of ADSCs that can differentiate into a cell of the leiomyogenic lineage, e.g., smooth muscle or skeletal muscle. In yet another...
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7528116 |
Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids...
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7527974 |
Embryonic stem cells derived from human somatic cell—rabbit oocyte NT units
The present invention discloses a process for obtaining somatic cell derived embryonic stem cells (encoded by reprogrammed somatic cell nuclei), ES cell-like cells or other types of embryo-derived...
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7527971 |
Adult stem cell lines
The present invention is directed to a new cell line, VIT4-G9, which has been deposited as ATCC Accession number PTA-8683.
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7524679 |
Methods for culturing human lung mast cells and uses thereof
Methods for culturing human lung mast cells in the absence of co-culture with feeder cells which are viable for longer than 4 days are provided. Also provided are methods for using these human lung...
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7521431 |
Compositions and methods for siRNA inhibition of HIF-1 alpha
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is...
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7517644 |
Method and compositions for cellular reprogramming
The present invention provides methods and compositions useful in treating certain diseases herein termed “Aberrant Programming Diseases,” including cancer and AIDS. According to one aspect of...
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7514548 |
Methods of inhibiting COX-2
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for COX-2, and further provides methods of reducing expression of COX-2 in cells (e.g., cancer cells).
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7514074 |
Cardiac muscle regeneration using mesenchymal stem cells
Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered...
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7504257 |
Embryonic stem cells and neural progenitor cells derived therefrom
The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production...
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7501401 |
Method for the modulation of function of transcription factors
There is provided a method of modulating the function of a transcription factor by administering an effective amount of an oligonucleotide containing optimal nucleotide binding site for the...
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7501281 |
Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells
The present invention relates to methods based on the interactions of thrombin as a biological regulator. More specifically, the invention relates to the interactions of thrombin with regard to...
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