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7417033 |
Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells
A pharmaceutical composition that blocks angiogenesis comprising as active agent at least one substance selected from the group consisting of (i) a nucleic acid molecule of a gene coding for...
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7414033 |
Modulation of diacylglycerol acyltransferase 1 expression
Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding...
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7413902 |
Feeder-free culture method for embryonic stem cells or primate primordial stem cells
Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a...
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7413901 |
Method of forming vertebrate pancreas in vitro
The present invention provides a pancreas induced in vitro that is useful for developmental engineering and organ engineering, and a method wherein a pancreas induced in vitro which contributes to...
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7410798 |
Culture system for rapid expansion of human embryonic stem cells
This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic...
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7407943 |
Antisense modulation of apolipoprotein B expression
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7407771 |
Cash (caspase homologue) with death effector domain, modulators of the function of FAS receptors
Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as...
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7405205 |
Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase
Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include...
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7399586 |
Modulation of biological signal transduction by RNA interference
Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that...
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7396809 |
Methods and reagents for treating glucose metabolic disorders
The invention relates to methods for potentiating, enhancing or restoring glucose responsivity in pancreatic islets or cells. The methods can be used as therapies for diseases caused by, or...
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7396529 |
Compositions and methods for regulating receptor clustering
The invention relates to isolated complexes comprising one or more galectin associated with Mgat5 modified glycan or polylactosamine modified glycan, and isolated lectin-Mgt5 modified glycan...
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7393683 |
Mammalian host cell modified by RNAi to inhibit α 1,6-fucosyltransferase
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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7393656 |
Methods and compositions for risk stratification
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of...
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7387880 |
Method for monitoring resting and activated platelets in unfixed blood samples
The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the...
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7384753 |
Growth differentiation factor-11
Growth differentiation factor-11 (GDF-11) is disclosed along with its polynucleotide sequence and amino acid sequence. The invention provides a method for identifying a compound that affects GDF-11...
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7381819 |
Composition for treatment or prevention of endometrial cancer and method of preventing or treating endometrial cancer using the composition
Provided are a composition for the treatment or prevention of an endometrial cancer including a nuclear acid molecule inducing RNA interference against human syndecan-1 gene expression and a...
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7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7378276 |
Method of inducing memory B cell development and terminal differentiation
A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature...
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7375092 |
Lunasin peptides
The invention provides methods and compositions of selectively disrupting mitotic function in a target cell demonstrating undesirable mitotic function. Suitable target cells include mammalian,...
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7371735 |
Inhibitor oligonucleotides and their use for specific repression of a gene
A method of treating a disease resulting from the expression of a harmful gene is described. The method includes the step of administering a therapeutically effective amount of a pharmaceutical...
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7371576 |
CD56 positive human adult pancreatic endocrine progenitor cells
The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stems cells having a high propensity to differentiate into...
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7368559 |
FcγRIIA-specific nucleic acid interference
The present invention provides methods and compositions for attenuating expression of FcγRIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a...
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7364869 |
Method of detecting antigen-specific T lymphocytes
The present invention provides a method of detecting antigen-specific T lymphocytes in a sample. The present invention further provides kits and systems for detecting antigen-specific T lymphocytes...
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7358088 |
Peptides and compositions which modulate apoptosis
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions...
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7358087 |
Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to...
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7358043 |
Proteomic interaction and genomic action determinations in the presence of associated redox state conditions
Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are...
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7355035 |
Catalytic molecules
The present invention relates to DNAzymes which are targeted against mRNA molecules encoding EGR-1 (also known as Egr-1 and NGFI-A). The present invention also relates to compositions including...
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7354730 |
High-throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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7354729 |
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to...
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7354703 |
Securin is required for chromosomal stability in human cells
Securin-deficient cells and their isogenic securin-proficient counterparts are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to...
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7351584 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
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7344881 |
Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing...
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7341870 |
Dendritic cell line
The invention relates to plasmacytoid dendritic human cell lines and methods for producing the cell lines. More specifically, the invention relates to the plasmacytoid dendritic human cell line...
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7338938 |
Methods for treating a patient undergoing chemotherapy
The present invention provides improved methods, kits, and pharmaceutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and...
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7335811 |
Method for collecting cells in M phase or G1 phase and method for nuclear transplantation using the cells
Methods for collecting cells in M phase or G 1 phase, by which the percentage of M phase or G 1 phase cells is higher than that attained by the conventional methods are disclosed.
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7335764 |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly...
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7332336 |
Methods for inducing differentiation of pluripotent cells
The present invention provides methods for inducing the differentiation of pluripotent cells. The present inventors succeeded in differentiating hepatocytes from ES cells without EB formation,...
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7332335 |
Decreasing cell proliferation by decreasing levels of PP5
The invention provides a method of increasing expression of p21 WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The...
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7332334 |
Hematopoietic stem cells treated by in vitro fucosylation and methods of use
A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an...
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7332276 |
Methods to increase or decrease bone density
The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new...
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7329796 |
Serial nuclear transfer of ungulate embryos
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7326570 |
Induction of tubular morphogenesis using pleiotrophin
Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are...
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7323620 |
Activation of equine oocytes
A method for activating an equine oocyte comprising exposing oocyte to a medium containing a concentration of calcium of at least about 4 mM. Preferably the oocyte is exposed to this concentration...
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7323337 |
Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors
Highly efficient gene transfer into primate-derived embryonic stem (ES) cells has successfully been achieved by using a simian immunodeficiency virus vector (SIV) pseudotyped with VSV-G protein,...
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7321075 |
Serial nuclear transfer of ungulate embryos
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7320965 |
Compositions and methods for inhibiting expression of Huntingtin gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which...
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7320885 |
Method of perforating membrane and apparatus therefor
A method of perforating a membrane 10 is presented. The method comprises: bringing a membrane-denaturing substance into contact with or close proximity to at least a site of said membrane 10 ,...
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7320880 |
Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same
A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between...
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7316926 |
Immortalized vascular adventital cell line
To provide an immortalized capillary pericyte line which maintains the original function/property of the cell line-deriving tissue, its establishment method, and the screening method for useful...
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7314855 |
Inhibition of ATF2 activity to treat cancer
The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies such as radiation,...
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