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7001723 |
Catalytic RNAs with aminoacylation activity
The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an...
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7001768 |
Targeted modification of chromatin structure
Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating...
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6998383 |
Inhibitors of receptor activator of NF-κB and uses thereof
The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide...
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6995140 |
Peptides and polypeptides useful for regenerating the nervous system
The invention concerns in particular novel peptides and polypeptides comprising at least the following sequence in amino acids: -W-S-A1-C-S-A2-C-G- in which A1 and A2 are amino acid sequences...
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6994959 |
G-rich oligo aptamers and methods of modulating an immune response
Aptamer oligonucleotides specifically bind to the DNA binding site of proteins such as Sp1 and Sp1-related proteins which regulate the genes which encode costimulatory molecules such as CD28 and...
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6989269 |
Cells for drug discovery
Disclosed herein are compositions and method useful in screening a compound for its interaction and/or effect with a molecular target and/or cellular process.
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6989270 |
Using polyamide nucleic acid oligomers to engender a biological response
The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells...
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6982172 |
Oocyte vitrification technique
A new method of cryopreservation based on the very fast cooling rates achieved by the direct contact of small droplets of vitrification solution containing biological sample with a very cold solid...
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6974698 |
Methods for delivering biologically active molecules into cells
Methods for delivering a biologically active molecule into a cell by linking a molecule to the cell surface, wherein the molecule can act as a surface receptor, then complexing the biologically...
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6972194 |
Use of polyacrylamide gel for forming a connective-tissue capsule in a mammal for cultivating allogenic and xenogenic cells
The invention relates to the field of medicine and more particularly it relates to the problem of vaccination against tumor cells and vaccinotherapy of oncological diseases, and also to a method of...
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6972195 |
Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro
Compositions and methods are provided for culturing in vitro potentially regenerative cells (PRCs) from which functional tissue-organs are regenerated. In one aspect of the invention, a tissue...
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6967100 |
Pancreatic islet cell growth factors
The present invention relates generally to growth factors and more particularly to growth factors which are capable of stimulating or otherwise facilitating formation of insulin-secreting cells....
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6967077 |
Methods and compositions for regulating T cell subsets by modulating transcription factor activity
Methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of a transcription factor, in particular the...
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6965025 |
Antisense modulation of connective tissue growth factor expression
Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense...
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6960446 |
Method for isolating cells expressing flk-2
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also...
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6958240 |
Inhibition of major groove DNA binding proteins by modified polyamides
This invention provides improved polyamides comprising a positive patch for contacting the phosphate backbone or major groove of a DNA molecule. As such, the improved polyamides are capable of...
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6958239 |
Three component chimeric antisense oligonucleotides
This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The...
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6958241 |
Therapeutic liposome composition and method
A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological...
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6955884 |
Methods for identifying compounds that inhibit CD38 activity
The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma,...
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6955924 |
Laminin chains: diagnostic uses
The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto.
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6953576 |
Method of modulating tumor immunity
Novel cells and molecules involved in tumor immunity are disclosed. The novel cells are regulatory T-cells having the phenotype CD3 + αβ-TcR + CD4 − CD8 − CD44 − CD28 − NK1.1 − . The...
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6953783 |
Modulation of gene expression by combination therapy
The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable...
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6951756 |
Closure of bacterial ghost
The invention relates to a method for preparing closed bacterial ghosts by means of vesicle membrane fusion and to the bacterial ghosts which can be obtained in this way. Active compounds, e.g....
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6949380 |
Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Disclosed is a method of transdifferentiating an epidermal basal cell into a cell having one or more morphological, physiological and/or immunological features of a neural progenitor, neuronal, or...
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6946447 |
MDM2-specific antisense oligonucleotides
The invention provides methods to activate tumor suppressors. The invention further provides antisense oligonucleotides complementary to a portion of the MDM2-encoding RNA and methods for using...
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6942986 |
Compositions and methods for regulating bacterial pathogenesis
The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a...
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6942979 |
Method for screening substances capable of modulating the activity of a TRAAK potassium channel
A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of such channels in drug screening.
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6943022 |
Inhibition of apoptosis by the expression of antisense RNA of caspase-3
The present invention relates to an antisense nucleotide of caspase-3, an expression vector encoding antisense RNA of caspase-3, and an inhibition method of cellular apoptosis in recombinant...
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6939712 |
Muting gene activity using a transgenic nucleic acid
The invention provides compositions and methods for muting expression of an endogenous gene in an animal cell, the muting resulting from providing a transgene to a cell. Expression of which...
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6939669 |
Expansion of hematopoietic cells using midkine or pleiotrophin
The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an...
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6936593 |
Method of down-regulating gene expression
Disclosed is a method of down-regulating the expression of a gene in an animal, wherein a pharmacological formulation comprising a chimeric oligonucleotide complementary to the gene is orally...
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6926888 |
Alginate capsules for use in the treatment of brain tumor
Encapsulated producer cells which are capable of expressing a molecule which is an inhibitor of CNS tumour growth provide a novel approach to the treatment of tumours, such as brain tumors which...
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6924142 |
Hypoxia-mediated neurogenesis assay
Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces...
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6924096 |
Delivery construct for antisense nucleic acids and methods of use
A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme...
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6919206 |
Medium containing flt3 ligand for culturing hematophoietic cells
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is...
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6919205 |
Regulation of type II collagen gene expression using specific and selective electrical and electromagnetic signals
Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and...
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6919209 |
Method of genetically modifying very primitive quiescent human hematopoietic stem cells
This invention relates to a method for transducing extremely primitive hematopoietic stem cells with high efficiency, using an adeno-associated vector. This vector stably transforms highly...
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6919204 |
Modulation of gene expression using localization domains
Methods and compositions for regulating gene expression are provided. In particular, methods and compositions comprising localization domains, and fusions of localization domains with DNA binding...
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6913925 |
Human mesencephalon cell lines and methods of use therefor
Conditionally-immortalized human mesencephalon cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including dopaminergic neurons. The cell lines and/or...
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6913911 |
Transgenic microbial polyhydroxyalkanoate producers
Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no...
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6906238 |
Effective nuclear reprogramming in mammals using CDK2 inhibitors
The present invention provides methods of producing a cloned non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include...
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6905874 |
Simultaneous stimulation and concentration of cells
The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and/or proliferation...
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6902902 |
Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other...
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6902882 |
Methods of monitoring production of gene products and uses thereof
This invention relates generally to the field of monitoring production of gene products. In particular, the invention provides methods of monitoring production of a gene product, methods of...
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6900053 |
Antisense modulation of fibroblast growth factor receptor 2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 2. The compositions comprise antisense compounds, particularly...
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6900054 |
Lineage restricted glial precursors from the central nervous system
A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5 + E-NCAM − glial-restricted precursor (GRP) cells are capable of differentiating into...
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6893813 |
Methods for treatment of HIV and other infections using a T cell or viral activator and anti-retroviral combination therapy
Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV...
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6893812 |
Three-dimensional ex vivo angiogenesis system
An in vitro tissue angiogenesis and vasculogenesis system is disclosed that allows the outgrowth of microvessels from a three-dimensional tissue fragment implanted in a matrix. The matrix may, for...
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6890908 |
Modified ribozymes
The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2′-position of the ribose sugar is replaced...
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6890753 |
Modified rapid expansion methods(“modified-REM”) for in vitro propagation of T lymphocytes
The present invention provides a modified rapid expansion method (termed “low-PBMC-REM” or “modified-REM”), for quickly generating large numbers of T lymphocytes, including cytolytic and...
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