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7101546 |
In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be matured in situ into a stable cell line that produces insulin in...
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7101707 |
Secondary sprouting for isolation and expansion of endothelial sprout cells and endothelial precursor cells from a mixed population and for screening substances
In vitro methods are disclosed that rely on a novel phenomenon of secondary sprouting by cultured endothelial precursor cells, after angiogenic-like tube formation and collapse have occurred on a...
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7101991 |
Compositions and methods for treatment of prostate and other cancers
Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers...
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7098190 |
Formulations comprising antisense nucleotides to connexins
A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site...
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7097965 |
Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein
The present invention provides a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary toxin protective antigen and the...
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7097996 |
Methods of screening test compounds using GADD34L, an eIF2α-specific phosphatase subunit
The invention is directed to methods and reagents for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening...
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7094529 |
Bunyaviridal reaper proteins and uses therefore
Viral proteins with sequence and functional similarity to the drosophila cell death protein known as Reaper are provided. Reaper plays an important role in the apoptotic pathway. Methods using the...
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7094394 |
Methods and compositions for controlling biofilm development
A method of cleaning or protecting surfaces by treatment with compositions comprising N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) blocking compounds and/or N-butyryl-L-homoserine lactone (BHL)...
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7094765 |
Antisense restenosis composition and method
The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a...
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7087431 |
Ex vivo generation of functional leukemia cells in a three-dimensional bioreactor
The present invention provides cultured leukemia cells. The method comprises isolating mononuclear cells, which contain leukemia cells, culturing the leukemia cells in a chamber having a...
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7087743 |
Oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents
The present invention relates to novel oligonucleotide sequences and also to derivatives thereof. These novel oligonucleotide sequences are capable of hybridizing specifically with the gene or...
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7087433 |
7SK RNA regulated transcription
A method for altering transcription in a cell comprising an amount of active CDK9/cyclin, comprises the steps of: (a) introducing in the cell an agent which modulates the amount of active...
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RE39229 |
Binding proteins for recognition of DNA
Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a...
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7087584 |
Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease
Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics...
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7078178 |
Methods of altering calcium transport
Methods of altering transmembrane calcium transport by altering expression of a calcium-transport protein are described.
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7078390 |
Ribozymes to growth factor originating in human platelet
A ribozyme comprising the following nucleotide sequence (SEQ ID NO:14) (I):
3′-GUGCCCCA GUACGGUG-5′ A C A UGA G AGU N 3 N 1 N 2
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7078230 |
Adipose tissue-derived stromal cell that expresses characteristics of a neuronal cell
The invention is in the area of pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof. In particular, the invention includes isolated adipose tissue derived...
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7074552 |
Method of forming vascularized kidney tissue
A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to...
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7074768 |
Modified protein kinase A-specific oligonucleotides and methods of their use
Disclosed are synthetic, modified oligonucleotides complementary to, and capable of down-regulating the expression of, nucleic acid encoding protein kinase A subunit RI α . The modified...
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7074762 |
Composition and method for improving function of embryonic kidney transplants
A method and composition for enhancing the development of metanephric tissue upon transplantation into an allogenic or xenogenic host are disclosed. Metanephric tissue is removed from an embryonic...
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7070946 |
Bone metabolism related protein and gene thereof
The present invention is directed to a novel method of detecting a function or activity of a polypeptide which is related to bone metabolism, in particular, differentiation (maturation) of...
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7071159 |
Inhibitor of vascular endothelial cell growth factor
The vascular endothelial cell growth factor (VEGF) inhibitors of the present invention are naturally occurring or recombinantly engineered soluble forms with or without a C-terminal transmembrane...
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7070996 |
Production of cultured human mast cells and basophils for high throughput small molecule drug discovery
Provided are methods for producing and screening proliferated populations of CD34-negative progenitor cells, mucosal mast cells, connective tissue-type mast cells and basophil cells. The methods...
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7067256 |
Ribozyme mediated inactivation of the androgen receptor
The present invention provides synthetic ribozyme oligonucleotides alone and within constructs. The ribozyme gene provides methods for the treatment of prostate hyperplasia and other androgen...
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7060279 |
Compositions and methods for dendritic cell-based immunotherapy
Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins...
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7060690 |
Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof
The present invention is directed to hybrid oligomers comprising a cyclic AMP response element (CRE) sequence and a sequence that hybridizes to a bcl-2 pre-mRNA or mRNA, and pharmaceutical...
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7056896 |
Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are oligonucleotides which contain at least one region of 2′-modified nucleosides...
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7052909 |
Method for activating NKT cells using PIMs
The invention concerns a pharmaceutical composition comprising at least a PIM-activated NKT cell and the use of at least one PIM and/or a PIM-activated NKT cell for treating a disease for which a...
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7052910 |
Skeletal cell model to screen anti-diabetic compounds
The present invention relates to the development of insulin resistant skeletal muscle cell culture model useful for the screening of compounds that enhance insulin receptor (IR) and insulin...
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7049139 |
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
The invention relates to materials and methods for producing equivalents of tissues of the ocular surface, especially conjunctival tissue equivalents. The method of the invention involves biopsy of...
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7045349 |
Method of islet isolation using process control
Advanced Islet Separation Technology incorporates an automated method, automated control methodology, process control interface, and automated apparatus to separate (isolate) and process pancreatic...
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7045315 |
Methods for modulating expression of exogenous genes in mammalian systems
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified...
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7045497 |
Use of peptide
The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on...
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7041654 |
Methods and compositions for inducing tumor-specific cytotoxicity
The present invention relates to the tumor-specific expression of heterologous polynucleotides, particularly genes encoding cytotoxic products, under the control of transcriptional regulatory...
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7041503 |
Modified myelin basic protein molecules
Compositions and methods are provided for the clinical assessment, diagnosis, and treatment of multiple sclerosis. The compositions of the invention are molecules related to the 21.5 kDa fetal...
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7041507 |
Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Disclosed is an in vitro method of transdifferentiating an epidermal basal cell into a cell having one or more morphological, physiological and/or immunological features of a glial cell. Also...
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7038014 |
Polycation-sensing receptor in aquatic species and methods of use thereof
Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.
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7037662 |
Receptor-ligand system and assay
An Eph family RTK (receptor tyrosine kinase) ligand-binding domain as well as a method of identifying Eph family RTK agonists or antagonist. The ligand-binding domain is suitably encoded by exon...
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7034007 |
Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletion
An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA, comprises the topical administration, e.g. to the respiratory system, of a subject of a therapeutic amount of an...
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7034009 |
Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more...
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7033830 |
Antisense modulation of MyD88 expression
Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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7033829 |
Method to inhibit cell growth using oligonucleotides
Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a...
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7029665 |
Human suppressor tRNA oligonucleotides and methods for use for same
Novel synthetic suppressor tRNA have been provided which provide read-through of internal nonsense mutations, or which can site-specifically alter translation of transcribed sequences. Uses of the...
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7029674 |
Methods for downmodulating immune cells using an antibody to PD-1
Disclosed are methods for downmodulating an immune response comprising contacting an immune cell with an agent that modulates the interaction between PD-1 and a PD-1 ligand (e.g., soluble forms of...
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7029879 |
Iodine uptake restoration in thyroid cancer
A method of expressing a tumor specific therapeutic response element in a cancerous cell is disclosed in which the response element was previously blocked from expression. The method comprises the...
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7029861 |
LPS-response gene compositions and methods
The present invention describes a mutant TLR-4 in mice that does not recognize endotoxin and therefore does not stimulate the secretion of TNF from macrophages. Methods of detecting the mutation...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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7005411 |
Method for modulating nerve cell function
The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated...
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7005297 |
Use of neuroactive compounds
The invention relates to a novel use of neuroactive compounds by treating the fruitfly Drosophila melanogaster adult males with fly medium containing either of the neuroactive compounds...
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7005274 |
Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the...
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