|
Match
|
Document |
Document Title |
|
|
7204999 |
Method of production of nanoparticle and nanoparticle produced by the method of production
The method of the production of a nanoparticle of the present invention includes a step of forming a nanoparticle including a compound of ametal ion in a cavity part of aprotein, in a solution...
|
|
|
7205283 |
Antisense oligonucleotides that inhibit expression of HIF-1
New antisense oligonucleotide compounds, RX-0047 and RX-0149, inhibit expression of HIF-1 and also induce cytotoxicity in several cancer cell lines.
|
|
|
7202395 |
Assessment method
A method of assessing the viability of a cell comprises incubating the cell in a culture medium. The culture medium includes a plurality of amino acids and the change in concentration in the medium...
|
|
|
7202080 |
Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
The subject invention comprises culture methods for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway. It also concerns the endocrine hormones that can be...
|
|
|
7198908 |
Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit
To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring...
|
|
|
7195758 |
Methods of inducing a T cell mediated immune response by administering antigen presenting B cells
We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B...
|
|
|
7195879 |
Method for identifying modulators of NAv ion channels
The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Na v expression is either Na v 1.3 in IMR-32 cells exposed to...
|
|
|
7192933 |
Use of a baculovirus to express an exogenous gene in a mammalian cell
Disclosed is a method of expressing an exogenous gene in a mammalian cell, involving infecting the cell with a baculovirus whose genome carries an exogenous gene, and growing the cell under...
|
|
|
7192773 |
Method of reducing neuronal electrical activity with a potassium channel subunit
Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K + channel (dORK) (SEQ ID NO:2) or a modified...
|
|
|
7192770 |
Screening for skin wrinkling modulators
The invention features methods of screening for compounds that prevent and/or reduce UVB-induced skin damage, e.g., wrinkles. The method includes identifying an agent that increases or induces the...
|
|
|
7192754 |
Nomuraeae rileyi-origin ecdysteroid 22-oxidase and molt hormone inactivation system with the use of the same
A material and a system are provided that efficiently inactivate a molting hormone by means of a protein having ecdysteroid 22-oxidase activity.
|
|
|
7193049 |
PRO862 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7189567 |
Method of culturing human chondrocytes
This invention provides a method for rapidly culturing a large amount of human chondrocytes to give normal chondrocytes or a mass thereof. The culture method comprises co-culturing human...
|
|
|
7186556 |
Modulating transcription of genes in vascular cells
A method of modulating the transcription of one or more genes in a vascular or cardiac cell, wherein the method comprises a step of contacting the cell with a composition comprising one or more...
|
|
|
7183108 |
Selection and uses of lactic acid bacteria strains modulating non-specific immunity
The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said...
|
|
|
7176304 |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor...
|
|
|
7176302 |
Liposomal phosphodiester, phosphorothioate, and p-ethoxy oligonucleotides
An improved delivery system for antisense oligonucleotides involves a liposomal composition, comprising a liposome which consists essentially of neutral phospholipids and an antisense...
|
|
|
7175843 |
Methods for selectively stimulating proliferation of T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
|
|
|
7175839 |
Cancer immunotherapy using allostimulated cells in a multiple sequential implantation strategy
This invention provides medicaments and methods for managing cancer using donor cells that are alloactivated in culture. Alloactivated cells are implanted into the bed of a solid tumor and initiate...
|
|
|
7173015 |
Inhibition of Syk kinase expression
The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).
|
|
|
7172871 |
Methods and compositions for modulating axonal outgrowth of central nervous system neurons
Methods and compositions for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following...
|
|
|
7172869 |
Methods for transfecting T cells
A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to...
|
|
|
7169607 |
In vivo induction for enhanced function of isolated hepatocytes
The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one...
|
|
|
7169608 |
Bone marrow cell differentiation
Bone marrow cells are induced to differentiate into pancreatic hormone-producing cells in vitro and to repopulate a pancreas in vivo. These insulin-producing cells can be used to regenerate a...
|
|
|
7169605 |
Methods of controlling proliferation and differentiation of stem and progenitor cells
A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions...
|
|
|
7163927 |
Antisense modulation of kinesin-like 1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
|
|
|
7157079 |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor...
|
|
|
7150992 |
Methods of preparing dendritic cells with flt3-ligand and antigen
Flt3-ligand can be used to generate large numbers of dendritic cells from hematopoietic progenitor and stem cells. Flt3-ligand can be used to augment immune responses in vivo, and expand dendritic...
|
|
|
7150989 |
Telomerase immortalized neural progenitor cells
The present invention relates to a method of immortalizing progenitor cells by providing a population of progenitor cells (e.g, neural progenitor cells) and immortalizing the progenitor cells...
|
|
|
7150970 |
Methods of inhibiting VEGF-C
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for VEGF-C, and further provides methods of reducing expression of VEGF-C in cells (e.g., cancer cells).
|
|
|
7148014 |
Methods of inhibiting phagocytosis
The present invention relates, in general, to methods of treating diseases resulting from interactions between immune complexes and Fc receptors. In particular, the present invention relates to...
|
|
|
7148343 |
Compositions and methods for using a solid support to purify RNA
Reagents, methods and kits for the purification of RNA from biological materials are provided.
|
|
|
7144575 |
Methods for selectively stimulating proliferation of T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
|
|
|
7144728 |
Method of inducing anergic T helper cells
This invention also provides a method of generating antigen specific human suppressor CD8+CD28− T cells. This invention further provides a method of generating allopeptide antigen specific human...
|
|
|
7141421 |
Control of metabolism with human 2-oxoglutarate carrier
The present invention is directed to compositions and methods related to the use of human OGC as an uncoupling protein.
|
|
|
7138378 |
Genetic suppression and replacement
A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of:
1. providing suppressing nucleic...
|
|
|
7138511 |
Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
In a preferred aspect of the invention, the upstream sequences of the TIGR protein encoding sequence can be used to diagnose a sensivity to steroids and a risk for glaucoma or ocular hypertensive...
|
|
|
7138517 |
Sugar modified oligonucleotides
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments,...
|
|
|
7138380 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
|
|
|
7132285 |
Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders
Treatment and/or prophylaxis, in mammalian patients, of neurodegenerative and other neurological medical disorders is effected by administering to the patient effective amounts of apoptotic bodies...
|
|
|
7125675 |
Method for inhibiting tumor invasion or spreading in a subject
The present invention provides for a method for inhibiting tumor invasion or metastasis in a subject which comprises administering to the subject a therapeutically effective amount of a form of...
|
|
|
7125714 |
Progenitor cell materials and methods
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such...
|
|
|
7125658 |
Small protein that interacts with a ribonucleotide reductase subunit and uses thereof
The present invention provides for an isolated Sml1 protein or a homologue thereof. The present invention also provides for a screening assay for identifying compounds that are capable of reducing...
|
|
|
RE39350 |
RNA binding protein and binding site useful for expression of recombinant molecules
The present invention relates to a gene expression system in eukaryotic and prokaryotic cells, preferably plant cells and intact plants. In particular, the invention relates to an expression system...
|
|
|
7122527 |
Use of antisense oligonucleotides to inhibit the expression of human Akt-1
New antisense oligonucleotide compounds inhibit expression of Akt-1 and also induce cytotoxicity in several cancer cell lines.
|
|
|
7119077 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to...
|
|
|
7118748 |
Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth...
|
|
|
7101709 |
Methods of screening biological agents
The invention discloses methods of proliferation and differentiation of multipotent neural stem cells. Also provided are methods of making cDNA libraries and methods of screening biological agents...
|
|
|
7101546 |
In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be matured in situ into a stable cell line that produces insulin in...
|
|
|
7101707 |
Secondary sprouting for isolation and expansion of endothelial sprout cells and endothelial precursor cells from a mixed population and for screening substances
In vitro methods are disclosed that rely on a novel phenomenon of secondary sprouting by cultured endothelial precursor cells, after angiogenic-like tube formation and collapse have occurred on a...
|