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7332334 |
Hematopoietic stem cells treated by in vitro fucosylation and methods of use
A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an...
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7332276 |
Methods to increase or decrease bone density
The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new...
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7332335 |
Decreasing cell proliferation by decreasing levels of PP5
The invention provides a method of increasing expression of p21 WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The...
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7332336 |
Methods for inducing differentiation of pluripotent cells
The present invention provides methods for inducing the differentiation of pluripotent cells. The present inventors succeeded in differentiating hepatocytes from ES cells without EB formation,...
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7329796 |
Serial nuclear transfer of ungulate embryos
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7326570 |
Induction of tubular morphogenesis using pleiotrophin
Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are...
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7323337 |
Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors
Highly efficient gene transfer into primate-derived embryonic stem (ES) cells has successfully been achieved by using a simian immunodeficiency virus vector (SIV) pseudotyped with VSV-G protein,...
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7323620 |
Activation of equine oocytes
A method for activating an equine oocyte comprising exposing oocyte to a medium containing a concentration of calcium of at least about 4 mM. Preferably the oocyte is exposed to this concentration...
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7320965 |
Compositions and methods for inhibiting expression of Huntingtin gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which...
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7320885 |
Method of perforating membrane and apparatus therefor
A method of perforating a membrane 10 is presented. The method comprises: bringing a membrane-denaturing substance into contact with or close proximity to at least a site of said membrane 10 ,...
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7316926 |
Immortalized vascular adventital cell line
To provide an immortalized capillary pericyte line which maintains the original function/property of the cell line-deriving tissue, its establishment method, and the screening method for useful...
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7314855 |
Inhibition of ATF2 activity to treat cancer
The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies such as radiation,...
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7314724 |
Therapeutic applications of laminin and laminin-derived protein fragments
Laminin and specific laminin-derived protein fragments are disclosed as potent inhibitors of Alzheimer's disease type amyloidoses. A specific region is identified within laminin which interacts...
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7312081 |
Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor...
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7312080 |
Plant resistance to insect pests mediated by viral proteins
The invention involves combining a peptide toxin effective against insects, including but not limited to thrips, leaf hoppers, and beetles, with a transport peptide capable of facilitating transfer...
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7307069 |
Antisense oligonucleotide modulation of STAT3 expression
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods...
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7304041 |
Modulators of coagulation factors
The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids...
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7303915 |
In vitro-differentiated retinal ganglion cells and method for producing same
In vitro-differentiated retinal ganglion cells can be produced by exposing a mammalian retinal ganglion cell line to a protein kinase inhibitor. The differentiated retinal ganglion cells can be...
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7304129 |
Peptides that stimulate cell survival and axon regeneration
Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any amino acid, Xaa...
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7297504 |
Methods for identifying agonists and antagonists of human T-type calcium channels
Sequences and partial sequences for three types of mammalian (human and rat) sequences identified) T-type calcium channel subunits which we have labeled as the α 1G , α 1H and α 1I subunits...
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7297539 |
Medium for growing human embryonic stem cells
This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic...
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7297684 |
Antisense therapy for hormone-regulated tumors
A method is provided for treating hormone-regulated tumors (for example, breast and prostatic tumors) in mammals, including humans, by administration of an antisense ODN which is complementary to a...
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7294508 |
Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines
A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the...
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7291484 |
Processes for culturing E1-immortalized cells to increase product yields
The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® (human embryonic retina) cells, to improve...
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7291451 |
Modulation of pericyte proliferation
Methods and materials for modulating pericyte and epithelial cell proliferation relating to BPI protein products or inhibitors thereof are provided.
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7288530 |
Antisense modulation of survivin expression
Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7282201 |
Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin
This invention has as its object providing promoters of the growth and/or differentiation of hematopoietic stem cells and/or hematopoietic progenitors which are useful as therapeutics of diseases...
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7279332 |
Method of isolating ependymal neural stem cells
The present invention relates to a method of determining whether a test compound is a proliferation-inducing or proliferation-inhibiting agent of ependymal neural stem cells. The method comprises:...
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7276352 |
Induction of β cell differentiation in human cells by stimulation of the GLP-1 receptor
The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1...
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7273756 |
Method for chondrocyte expansion with phenotype retention
The present invention provides a method that maintains chondrocyte phenotype during serial expansion by culturing a population of chondrocytes in a defined serum-free culture medium containing...
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7273755 |
Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds
Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell...
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7270968 |
PTH analogs for renal osteodystrophy and related uses
The invention relates to a mammalian cell lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1R) activity and containing carboxyl-terminal parathyroid...
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7267980 |
Stabilizing solution for cells and tissues
Methods and compositions for stabilizing tissues, cells, and cell components such that desired antigenic sites, light scatter properties and cellular morphology are preserved for a useful period of...
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7267981 |
Human foreskin fibroblasts for culturing ES cells
A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
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7264968 |
Method of inducing and maintaining neuronal cells
The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems...
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7262175 |
Synthetic oligonucleotides as inducers of erythroid differentiation
The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a)...
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7238675 |
Antisense antibacterial method and composition
The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use....
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7238360 |
Alteration of cell membrane with B7
Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene...
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7238525 |
Strategy for leukemia therapy
The chimeric Bcr-Abl oncoprotein is the molecular hallmark of chronic myelogenous leukemia (CML). In the cytoplasm, the protein transduces a growth signal that is responsible for overexpansion of...
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7232566 |
Methods for treating HIV infected subjects
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7229762 |
Proteomic screening for redox state dependent protein—protein interactions
This invention provides a modified yeast two-hybrid system in order to identify NO-dependent protein-protein interactions. Bait proteins implicated in apoptotic signaling pathways were used to...
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7223391 |
Method for treating mammals with modified mammalian blood
An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to...
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7223556 |
Targeted proteolysis by recruitment to ubiquitin protein ligases
The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and...
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7220583 |
Pseudomonas avr and hop proteins, their encoding nucleic acids, and use thereof
One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid...
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7220584 |
Method of making embryoid bodies from primate embryonic stem cells
Primate embryoid bodies are formed from primate ES cells. The ES cells form clumps. One then removes the clumps, as clumps, and permits incubation under non-adherent conditions. The development of...
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7217568 |
Methods of identifying and isolating stem cells and cancer stem cells
Methods and compositions are provided for the identification of stem cells and cancer stem cells. β-catenin is also identified as a target for the development of therapeutic moieties against...
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7214497 |
Viral encoded semaphorin protein receptor DNA and polypeptides
The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for...
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7211436 |
Compositions and methods for regulating abscisic acid-induced closure of plant stomata
A novel gene, AAPK, is disclosed. Loss of function of the protein encoded by AAPK is associated with reduced sensitivity to abscisic acid-induced stomatal closure in plants. Also disclosed are...
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7211434 |
Primitive neural stem cells and method for differentiation of stem cells to neural cells
Described are a novel cell type in the neural lineage, and method of producing the same based on the degree of neural commitment and growth factor responsiveness in vitro and the potential to give...
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7208283 |
Methods for determining hormonal effects of substances using Ewing sarcoma protein and androgen receptor
In the method of determining hormonal effects of substances, a test substance is contacted with Ewing sarcoma protein (EWS) or a derivative of it and with an androgen receptor (NR) or a derivative...
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