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7618792 |
Multiplexed detection of anti-red cell alloantibodies
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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7618621 |
Mammalian multipotent neural stem cells and compositions, methods of preparation and methods of administration thereof
This invention relates to novel mammalian multipotent neural stem cells (MNSCs), compositions thereof, and methods of preparing and administering the cells to diseased, aged or damaged tissue such...
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7601687 |
Mechanism for identifying drugs for the treatment of type II diabetes
Insulin resistance is a central feature of type II diabetes and other diseases, and may affect every tissue of the body, including the pancreatic beta cell. Insulin signaling is mediated by a...
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7598082 |
Process of mammalian cell reprogramming through production of a heterokaryon
This invention relates to the reprogramming of animal cells and animal cell nuclei by nuclear addition. The invention also relates to the generation of animal cells, cell lines, tissues, organs,...
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7592176 |
Method of forming mesenchymal stem cells from embryonic stem cells
This invention relates to methods of producing a substantially homogenous population of mesenchymal stem cells derived from embryonic stem cells. Also, disclosed is a homogenous population of...
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7592175 |
Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and cell cultures prepared using same
The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being...
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7588936 |
Generating teeth from bone marrow cells
The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for...
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7582479 |
Primate embryonic stem cell line
A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+);...
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7572630 |
Method for differentiating primate embryonic stem cell into vascular cell
To provide a technique of the differentiation from a primate embryonic stem cell into a vascular cell, and techniques using the same. A method for differentiating a primate embryonic stem cell into...
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7560105 |
Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses
The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in...
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7553664 |
Three-dimensional skin model
The present invention relates to methods for cultivating dermal fibroblasts, methods for preparing in vitro dermis equivalents, methods for preparing three-dimensional in vitro skin equivalents, an...
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7553662 |
Culturing tissue using magnetically generated mechanical stresses
A method of culturing tissue comprises growing tissue forming cells whilst subjecting the tissue forming cells to mechanical stresses which are generated magnetically.
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7547818 |
Metaphase donor cells for effective nuclear reprogramming in mammals
The present invention provides methods of producing a clone non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include...
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7547545 |
Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods...
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7541183 |
Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling
Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening...
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7534609 |
Method of expanding undifferentiated hemopoietic stem cells
A method of expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) obtaining the undifferentiated hemopoietic...
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7521197 |
Method for producing cytotoxic T-cells
The invention relates to the method for producing antipeptide cytotoxic T lymphocytes (CTLs) by attaching a complex of a class I HLA and a peptide to antigen presenting cell(s) (APCs) present in a...
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7517647 |
Genetic screen for bioactive peptides
A method of screening for a protein involved in the extracellular regulation of latent TGFβ activation by transducing a cell line with a retroviral cDNA library to create a reporter cell line that...
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7514229 |
Methods for diagnosing and evaluating treatment of blood disorders
Methods, systems and kits are provided for the clinical staging of blood disorders including myelodysplastic syndrome, myeloproliferative diseases and leukemias by differential analysis of...
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7501232 |
Method for cell selection
The invention relates to a method for the non-invasive selection of single living cells under gentle conditions from mixtures of cells or cell cultures with respect to a specific production...
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7498168 |
Tooth progenitor cell and method for its production
The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
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7494811 |
In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
The present invention is directed to a method of growing new bone, bone-like tissue or extracellular matrix under in vitro cell culture conditions. The method utilizes a bioreactor allowing for the...
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7494810 |
Method for accessing microbial diversity
A method of interfering with quorum sensing regulation of genes to promote cell growth is disclosed. The method of is aimed at accessing microbial biodiversity. The method involves obtaining an...
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7470424 |
Cultured cell construct containing spheroids of cultured animal cells and utilization thereof
Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A...
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7462484 |
Amorphous cell delivery vehicle treated with physical/physicochemical stimuli
Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro...
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7462483 |
p27 and p21 in gene therapies
The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21 cip1/waf1 and/or p27, cyclin dependent kinase...
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7459282 |
Use of c-Jun or c-Jun activating agents such as UV or c-Jun N-terminal kinases (JNKs) for treating cancer
The invention concerns the increased stabilization and activation of p73, a homologue of p53. Specifically, the inventors have determined that c-Jun, a component of the AP-1 family of transcription...
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7456017 |
Processes for clonal growth of hepatic progenitor cells
A method of propagating mammalian endodermally derived progenitors such as hepatic progenitors, their progeny, or mixtures thereof is developed which includes culturing mammalian progenitors, their...
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7432104 |
Methods for the culture of human embryonic stem cells on human feeder cells
Methods and cell culture medium for the generation of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human granulosa feeder cells, muscle cells,...
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7410798 |
Culture system for rapid expansion of human embryonic stem cells
This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic...
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7402432 |
Process for producing T lymphocytes
The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts.
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7402430 |
MHC class II antigen-presenting systems and methods for activating CD4+ T cells
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC...
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7399632 |
Mesenchymal precursor cell
A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for...
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7396681 |
Application of Hsp70 proteins
The invention relates to the use of Hsp70 protein or fragments thereof for the activation of NK-cells, pharmaceutical preparations, medical product or medical adjuvants containing a Hsp70 protein...
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7393687 |
Biomimetic 3-dimensional scaffold with metabolic stream separation for bioartificial liver device
A bio-artificial organ comprises a substrate comprising a roll of a substrate material, and a plurality of cells adhered to the substrate, the roll being formed from a sheet rolled to form a...
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7393685 |
Method for cultivating cancer cells from human tissue and device for preparing tissue samples
The invention relates to a method for cultivating cancer cells for scientific serial assays, wherein a tissue sample which is heterogeneous with respect to contaminants, normal cells and tumor...
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7371576 |
CD56 positive human adult pancreatic endocrine progenitor cells
The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stems cells having a high propensity to differentiate into...
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7361506 |
Differentiation of specialized dermal and epidermal cells into neuronal cells
Cells are generated from skin biopsies for use in cell implantation by identifying a source of skin cells that have a surface concentration of at least one cell selected from the group consisting...
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7312030 |
Adaptation sites of porcine reproductive and respiratory syndrome virus
A method for determining the capability of an arterivirus to replicate in a permissive cell is disclosed. The method includes determining an amino acid at a position that corresponds to an amino...
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7312025 |
Methods and systems for extended in vitro culture of neuronal cells
A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides...
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7300760 |
Mammalian myeloid progenitor cell subsets
A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for myeloid lineages, but lacking the potential to differentiate...
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7297539 |
Medium for growing human embryonic stem cells
This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic...
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7288405 |
Devices and methods for pharmacokinetic-based cell culture system
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
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7267981 |
Human foreskin fibroblasts for culturing ES cells
A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
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7259012 |
Use of oxidized lipoproteins for differentiation of precursor cells into mature dendritic cells
The invention concerns a method for differentiating precursor cells into mature dendritic cells, comprising placing the precursor cells in a medium suitable for their differentiation and adding to...
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7252995 |
Method of generating neurons from stem cells and medium for culturing stem cells
The present invention relates to a method of generating neurons from stem cells which comprises culturing neurons in a medium and culturing the stem cells in the resultant mixture. The present...
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7252982 |
Tissue engineering enhanced by the transfer of a growth factor gene
Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a...
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7250286 |
Methods for the in vitro culture of Sporozoea sp. and uses thereof
The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an...
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7247479 |
Pigment epithelial cell of the eye, its production and use in therapy of an eye or CNS disease
The present invention relates to a pigment epithelial cell of the eye containing vector DNA of an adenoviral vector with large DNA capacity, to the improved isolation and cultivation of these cells...
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7244552 |
Artificial dermis and production method therefor
Artificial dermis ( 1 ) obtained from plasma with platelets ( 2 ) and human fibroblasts. The plasma with platelets ( 2 ) is obtained from the fractionating of total blood ( 4 ) from the patient ( 8...
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