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7613573 |
Pricing of the identification service by a registry which identifies prospective donors having particular bloodtypes to a requisitioner
Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances...
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7601534 |
Method for multiplying stem cells
The use of a cellular development inhibitor in a controlled manner in order to maintain an undifferentiated stem cell state, especially one of human stem cells, whereby cell division is permitted.
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7598081 |
Materials and procedures for the purification of cells
The subject invention provides new materials and methods for the efficient isolation and purification of stem cells. Specifically, conductive immunopolymers with stem cell specific antibodies can...
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7588936 |
Generating teeth from bone marrow cells
The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for...
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7588905 |
Identification and monitoring of systemic lupus erythematosus
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
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7585640 |
Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
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7582313 |
Methods of organ regeneration using Hox 11-expressing pluripotent cells
The invention features methods for increasing or maintaining the number of functional cells of a predetermined type in a mammal (e.g., a human patient), for example, the insulin producing cells of...
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7575925 |
Cell preparations comprising cells of the T cell lineage and methods of making and using them
The invention relates to cell preparations comprising cells of the T cell lineage, methods for preparing same, and uses of the cell preparations.
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7572631 |
Activation and expansion of T cells
The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7560280 |
Human cord blood derived unrestricted somatic stem cells (USSC)
A composition in human cord and placental blood which comprises unrestricted somatic stem cells is described here which can be amplified in vitro to large quantities sufficient for medical...
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7560243 |
White blood cell functional assay
A method of rapidly assaying nucleotide receptor P2X 7 pore activity in white blood cells contained within a blood sample. A method according to the invention includes the steps of: (a) labeling...
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7560105 |
Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses
The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in...
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7547551 |
Transfection of eukaryontic cells with linear polynucleotides by electroporation
The present invention provides an improved method for gene delivery in eukaryotic cells by electroporation, preferably in human hematopoietic cells, particular dendritic cells. The method of the...
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7541182 |
In vitro test to detect risk of preeclampsia
The present invention provides methods for identifying patients at risk of developing preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients...
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7527978 |
Flow cytometry based micronucleus assays and kits
The invention is a method for analyzing immature reticulocytes for the presence of micronuclei. The method includes reticulocyte enrichment, fluorescent labeling, micronuclei staining, and analysis...
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7527968 |
Regeneration initiating cells
Methods and compositions for treating hyperglycemia and pancreatic damage as well as stimulating the repair or regeneration of islet cells are disclosed.
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7514537 |
Chimeric immunoreceptor useful in treating human gliomas
The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region...
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7514261 |
Platelet-derived growth factor protection of cardiac myocardium
The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.
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7510877 |
Hematopoietic stem cell identification and isolation
The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides...
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7510870 |
STAT3 activated stem cell
Stem cells modified to express activated form of STAT3 by genetic modification or protein delivery, and stem cells co-cultured with cells expressing activated form of STAT3 exhibit increased...
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7504099 |
Methods of inducing or enhancing connective tissue repair
This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a...
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7498023 |
Blockade of T cell migration into epithelial GVHD target tissues as an approach to achieving anti-tumor effects against lymphohematopoietic malignancies without GVHD
Antagonists of T cell migration are used to reduce GVHD in recipients of hematopoietic cell grafts. The administration of antagonists of T cell migration can be used in combination with...
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7494806 |
Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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7491534 |
Methods for altering cell fate to generate T-cells specific for an antigen of interest
The invention provides methods for altering the expression profile of a cell to convert the cell from one cell type to a desired cell type (e.g., T-cells). These reprogrammed cells may be used in a...
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7491530 |
Fusion partner cells and uses thereof
The present invention provides in one aspect novel fusion partner cells that ectopically express one or more genes that alter the phenotype of a hybrid cell made from a fusion of the fusion partner...
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7485460 |
Enhanced growth of adult stem cells with Dkk-1
The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells.
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7476535 |
TRP2 isoform TRP2-6b containing HLA-A2 restricted epitopes
The present invention relates to a new and potent tumor antigen capable of causing T cells to elicit an immune response and methods of its use in the detection, prevention, and treatment of cancer,...
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7462485 |
Modified erythrocytes and uses thereof
The present invention provides modified erythrocytes which comprise viral receptor proteins capable of mediating entry of respective viruses into the modified erythrocytes. The present invention...
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7462484 |
Amorphous cell delivery vehicle treated with physical/physicochemical stimuli
Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro...
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7462483 |
p27 and p21 in gene therapies
The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21 cip1/waf1 and/or p27, cyclin dependent kinase...
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7449340 |
Method for the early diagnosis of cancer
The present invention relates to a method for the early diagnosis of cancer in a subject, which is based on determination of the relative fraction of microorganisms derived from the feces of the...
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7446191 |
DNA construct encoding CE7-specific chimeric T cell receptor
Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular...
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7442397 |
PEGylated fibrinogen-based biomatrix
The invention involves methods and materials related to fibrin-based biomatrices.
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7442390 |
Method for enhancing engraftment of cells using mesenchymal progenitor cells
The present invention provides isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), which simultaneously express a plurality of genes that are markers for multiple cell...
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7439037 |
Use of aminoglycoside resistance gene
Use of aminoglycoside resistance gene product for achieving high-density growth of animal cells.
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7435592 |
Compositions for allogeneic cell therapy
A method of manipulating allogeneic cells for use in allogeneic cell therapy protocols is described. The method provides a composition of highly activated allogeneic T-cells which are infused into...
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7432253 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula:
where R1 is selected from among —CH 3 and —CH 2 —CH 3 .
Cat+ is an organic or...
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7431932 |
Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with...
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7429489 |
Methods of controlling proliferation and differentiation of stem and progenitor cells
A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions...
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7425448 |
Cardiomyocyte precursors from human embryonic stem cells
This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting...
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7422736 |
Somatic pluripotent cells
The present invention discloses a cultured somatic animal cell having a normal karyotype; the cell develops into an embryoid body when induced in vitro, or develops into a teratoma when introduced...
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7413869 |
Method for determining potency of antigenic presenting cell based vaccines
The present invention discloses methods useful in the preparation of immunostimulatory vaccines which include as one of their components, activated antigen presenting cells which are characterized...
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7413868 |
Use of particulate labels in bioanalyte detection methods
New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular...
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7413652 |
Method for the production of a blood component composition
A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple...
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7405077 |
Sperm protein 17 for the diagnosis and treatment of cancer
The results herein identify Sp17 as a novel cancer-testis antigen in multiple myeloma. Sp17 recombinant protein was generated from E. coli . A CD8 predominant CTL line was generated that was able...
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7405076 |
Generation and use of dendritic cells
The present invention relates to an in vitro method for differentiation and maturation of isolated monocytes into IL3-R+CD11c+ myeloid dendritic cells consisting of incubating the monocytes with a...
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7402432 |
Process for producing T lymphocytes
The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts.
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7402431 |
T-cell therapy formulation
Ex-vivo prepared T-cells are harvested from cell culture conditions and formulated in medium suitable for infusion. The formulation is made by labeling the cells with one or more agents which have...
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7399633 |
Methods for immortalizing cells
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in...
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