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7575925 |
Cell preparations comprising cells of the T cell lineage and methods of making and using them
The invention relates to cell preparations comprising cells of the T cell lineage, methods for preparing same, and uses of the cell preparations.
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7572631 |
Activation and expansion of T cells
The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of...
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7514537 |
Chimeric immunoreceptor useful in treating human gliomas
The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region...
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7494806 |
Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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7491534 |
Methods for altering cell fate to generate T-cells specific for an antigen of interest
The invention provides methods for altering the expression profile of a cell to convert the cell from one cell type to a desired cell type (e.g., T-cells). These reprogrammed cells may be used in a...
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7476535 |
TRP2 isoform TRP2-6b containing HLA-A2 restricted epitopes
The present invention relates to a new and potent tumor antigen capable of causing T cells to elicit an immune response and methods of its use in the detection, prevention, and treatment of cancer,...
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7446191 |
DNA construct encoding CE7-specific chimeric T cell receptor
Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular...
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7435592 |
Compositions for allogeneic cell therapy
A method of manipulating allogeneic cells for use in allogeneic cell therapy protocols is described. The method provides a composition of highly activated allogeneic T-cells which are infused into...
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7432253 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula:
where R1 is selected from among —CH 3 and —CH 2 —CH 3 .
Cat+ is an organic or...
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7413868 |
Use of particulate labels in bioanalyte detection methods
New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular...
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7405077 |
Sperm protein 17 for the diagnosis and treatment of cancer
The results herein identify Sp17 as a novel cancer-testis antigen in multiple myeloma. Sp17 recombinant protein was generated from E. coli . A CD8 predominant CTL line was generated that was able...
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7402431 |
T-cell therapy formulation
Ex-vivo prepared T-cells are harvested from cell culture conditions and formulated in medium suitable for infusion. The formulation is made by labeling the cells with one or more agents which have...
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7402432 |
Process for producing T lymphocytes
The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts.
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7361479 |
Assay
The present invention provides a method of determining the presence or amount of newly synthesized antibody in a sample in response to an immunogen by detecting the released antibodies or parts...
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7354762 |
Method for producing CE7-specific redirected immune cells
Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular...
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7344830 |
Heteroduplex tracking assay
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown...
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7335351 |
Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme
The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune...
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7332295 |
Multidimensional leukocyte differential analysis
This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells,...
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7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
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7320787 |
Redirection of cellular immunity by protein tyrosine kinase chimeras
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an...
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7306927 |
Method of inducing immunity against stratum corneum chymotrytic enzyme
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected...
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7265209 |
CE7-specific chimeric T cell receptor
Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular...
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RE39788 |
Gene therapy
Primary human cells which are genetically engineered with DNA (RNA) encoding a marker or therapeutic which is expressed to be expressed in vivo. Such engineered cells may be used in gene therapy.
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7217567 |
Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments
The present invention relates to methods for lyophilizing eukaryotic cells and isolating intact nucleic acids from such cells, and related kits for using the same.
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7192769 |
Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen...
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7172900 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Isolated CD8+T lymphocytes specifically cytotoxic for a disease causing target cell
Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial...
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7160723 |
Cell separation compositions and methods
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even...
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7132243 |
Clonal expansion of T cells of unknown specificity and identification of ligand recognized by the clonally expanded T cells
A process for clonally expanding T cells of unknown specificity and a process for identifying a peptide ligand recognized by said T cells are provided. A process for clonally expanding T cells of...
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7105157 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
The present invention relates to cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells...
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7101711 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula:
where R1 is selected from among —CH 3 and —CH 2 —CH 3 ,
Cat+ is an organic or...
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7094557 |
2-Methyl-3-butenyl-1-pyrophosphoric acid salt and agent for treating lymphocytes
A pharmaceutically acceptable salt of 2-methyl-3-butenyl-l-pyrophosphoric acid; an agent for treating lymphocytes which comprises at least one of 2-methyl-3-butenyl-l-pyrophosphoric acid, a...
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7070995 |
CE7-specific redirected immune cells
Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular...
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7052703 |
T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof
This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame...
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7041502 |
Isolated peptides which bind to HLA-B18 molecules and uses thereof
A peptide, previously identified as a binding partner of HLA-B44, has now been found to bind to HLA-B18 forming a T cell epitope. The therapeutic and diagnostic ramifications of this are the...
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7026132 |
Method of monitoring the effect of Cathepsin S inhibitors
The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant...
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6984382 |
Bifunctional protein, preparation and use
A bifunctional protein comprising: 1) a single-chain antibody directed against a suitable antigen on a tumour cell, 2) a hinge region comprising from about 40 to about 200 amino acids joined to the...
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6977073 |
Method for stimulating an immune response
A method is described whereby dendritic cells derived from the CD34+ and CD 34−hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may...
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6905874 |
Simultaneous stimulation and concentration of cells
The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and/or proliferation...
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6902929 |
Retroviral vectors, methods for their preparation and their use for gene transfer into CD4-positive cells
The invention relates to the production and use of retroviral vectors for cell specific gene transfer, specially to a production method of retroviral vectors containing capsid particles of murine...
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6900010 |
Compositions and methods for detecting human immunodeficiency virus
Methods are provided for screening natural and synthetic anti-HIV agents using recombinant cells that are rendered susceptible to productive infection of various strains, subtypes or clades of HIV...
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6887707 |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates...
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6884576 |
Methods of monitoring HIV drug resistance
A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or...
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6828147 |
Method of modifying cytotoxic cells and uses thereof
TALL-104 cells, and other cytotoxic T cell lines, may be modified to increase the cytotoxicity thereof, to enhance growth properties, and/or to provide a preferred phenotype, e.g., expression of...
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6821778 |
Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
This invention relates to methods of using human dendritic cells to present antigens for the induction of antigen-specific T cell-mediated immune responses. In particular, it relates to the...
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6805861 |
Immunotherapy using cytotoxic T lymphocytes (CTL)
A method of treating a patient with a disease wherein the patient contains diseased cells which cells contain, or are associated with, an abnormal molecule or an abnormally elevated amount of a...
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6797480 |
Purification of heat shock/stress protein cell surface receptors and their use as immunotherapeutic agents
The present invention relates to receptors for heat shock proteins (HSPs), such as gp96, Hsp70 and Hsp90. The heat shock receptor is associated with the cell membranes of a subset of antigen...
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6770749 |
P53-specific T cell receptor for adoptive immunotherapy
The present invention relates to molecular cloning of cDNA for both A and B chains of hu p53-specific, HLA restricted mu TCR, transfer of the cDNA to hu T cells, and functional expression of the...
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6716425 |
Method of preventing cancer recurrence
Methods for treating cancer in a mammalian patient having cancer and a functional immune system, and for preventing recurrences of cancer following completion of cancer therapy, are described. The...
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6696267 |
Methods and compositions for screening Icrac modulators
The present invention relates to compositions and methods directed at screening or characterizing compounds that modulate the activity of calcium channels in cells preferably, calcium-release...
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RE38423 |
Process for in vitro analysis of toxic and allergenic substances
The invention concerns a process for in vitro evaluation of a potentially allergenic or tissue irritating substances, characterized in that blood cells are cultivated in the presence of serial...
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